Tricaine mesylate

Tricaine mesylate

Clinical data
Other names	Metacaine Tricaine MS-222 Finquel TMS
ATCvet code	QN01AX93 (WHO)
Identifiers
IUPAC name Ethyl 3-aminobenzoate methanesulfonic acid
CAS Number	886-86-2 Y
PubChem CID	13454
ChemSpider	12878 N
CompTox Dashboard (EPA)	DTXSID6022133
ECHA InfoCard	100.011.779
Chemical and physical data
Formula	C10H15NO5S
Molar mass	261.296 g/mol g·mol−1
3D model (JSmol)	Interactive image
Melting point	149.5 °C (301.1 °F)
SMILES [NH3+]C1=CC=CC(C(OCC)=O)=C1.CS(=O)([O-])=O
InChI InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4) N Key:FQZJYWMRQDKBQN-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Tricaine mesylate (Tricaine methanesulfonate, TMS, MS-222), is white powder used for anesthesia, sedation, or euthanasia of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption. The drug can have selective toxicity for poikilotherms due to their lower rate of metabolism in the liver.

TMS is a muscle relaxant that operates by preventing action potentials. By blocking action potentials, no signals can be exchanged between the brain and the extremities. There will be no sensory input or muscle contractions which would have been caused by action potential, which includes most muscles.

The optimum concentration may vary with the size and species of the fish, and other variables.

It is easily soluble in water (both fresh and salt) but it drastically decreases the pH of water, increasing the acidity, which may be toxic for fish. Sodium bicarbonate can be used to buffer the solution to a pH range of 6.5-7.5. Usually an equal amount of buffer is added to attain a neutral pH. In salt/marine/sea water, the buffer use may not be necessary because sea water itself has buffering capacity.

The solution of TMS needs to be prepared freshly each time because TMS is light-sensitive and might form toxic by-products upon exposure to light.