Trimethoprim/sulfadoxine
 | This article relies largely or entirely on a single source. (November 2011) |
Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both Gram-negative and Gram-positive bacteria.[1]
Veterinary uses
Trimethoprim/sulfadoxine is used in the treatment of swine and cattle; including dairy cattle, beef cattle and veal.
In cattle, it is used to treat:
- Respiratory tract infections such as, bovine pneumonia pasteurellosis (shipping fever)[1]
- Alimentary tract infections such as salmonellosis and both enteric and septicaemic colibacillosis.[1]
- Other infections such as pododermatitis (foot rot) and septicaemias.[1]
In swine, it is used to treat:
- Respiratory tract infections such as, bacterial pneumonias.[1]
- Alimentary tract infections such as, post-weaning scours and colibacillosis.[1]
- Other infections such as bacterial arthritis and mastitis-metritis-agalactia syndrome in sows.[1]
Contraindications
Trimethoprim/sulfadoxine is contraindicated in cattle or swine that show marked liver parenchymal damage or blood dyscrasias, or those with a history of sulfonamide sensitivity.[1]
Milk from an animal treated with trimethoprim/sulfadoxine must not be consumed for at least 96 hours following the most recent treatment; treated animals must not be slaughtered for use in food for at least ten days after the last treatment.[1]