Trimix (drug)

Trimix
Combination of
Alprostadil	prostaglandin
Papaverine	vasodilator
Phentolamine	alpha blocker
Clinical data
Routes of; administration	injection, topical
Legal status
Legal status	US: ℞-only;
Identifiers
ChemSpider	none;
	(verify)

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection (an injection at either side, not the base, of the penis).^[1]^[2]^[3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to six months while stored frozen and for one month if stored refrigerated beginning at the time of manufacture.^[4]

References

^ R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E₁". International Journal of Impotence Research. 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ S.C. Kim; I.H. Chang; H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International. 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483.
^ S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology. 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.
^ Trissel Lawrence A; Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235.

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[1] R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E₁". International Journal of Impotence Research. 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[2] S.C. Kim; I.H. Chang; H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International. 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483.

[3] S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology. 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.

[4] Trissel Lawrence A; Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235.

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