Trimix (drug)

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Combination of
Alprostadil prostaglandin
Papaverine vasodilator
Phentolamine alpha blocker
Clinical data
  • US: D (Evidence of risk)
Routes of
gel, injection, topical
Legal status
Legal status
ChemSpider none

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection (an injection at the base of the penis).[1][2][3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to 6 months while stored frozen and for 1 month if stored refrigerated beginning at the time of manufacture.[4]


The common initial dose should be .05cc to .2cc depending on the patients level of ED. Wait 48 hours before increasing dosage. Increase by 0.025 cc to 0.050 cc until a satisfactory dose is reached, or sometime it may subject to change by the doctor and or pharmacy. Its a strict prescribed medicine, due to the varying amount of dose, Purchasing/selling without prescription is illegal.[5]


  1. ^ R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683. 
  2. ^ S.C. Kim; I.H. Chang; H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483. 
  3. ^ S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870. 
  4. ^ Trissel Lawrence A; Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235. 
  5. ^ TriMix Injection, 6th Sub Heading, Olympia Compounding Pharmacy, Orlando, 2012