Trimix (drug)

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Combination of
Phentolaminealpha blocker
Clinical data
  • US: D (Evidence of risk)
Routes of
injection, topical
Legal status
Legal status
  • none

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection (an injection at either side, not the base, of the penis).[1][2][3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to six months while stored frozen and for one month if stored refrigerated beginning at the time of manufacture.[4]


  1. ^ R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research. 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683.CS1 maint: Multiple names: authors list (link)
  2. ^ S.C. Kim; I.H. Chang; H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International. 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483.
  3. ^ S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology. 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.
  4. ^ Trissel Lawrence A; Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235.