Trimix (drug)

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Combination of
Phentolaminealpha blocker
Clinical data
Routes of
injection, topical
Legal status
Legal status
  • none

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection (an injection at either side, not the base, of the penis).[1][2][3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to six months while stored frozen and for one month if stored refrigerated beginning at the time of manufacture.[4]


  1. ^ Seyam R, Mohamed K, Akhras AA, Rashwan H (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research. 17 (4): 346–53. doi:10.1038/sj.ijir.3901313. PMID 15772683.
  2. ^ Kim SC, Chang IH, Jeon HJ (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International. 92 (3): 277–80. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483. S2CID 41078747.
  3. ^ Israilov S, Baniel J, Shmueli J, Niv E, Engelstein D, Segenreich E, Livne PM (March 2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology. 93 (6): 689–93. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.
  4. ^ Trissel LA, Zhang Y (2004). "Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction". International Journal of Pharmaceutical Compounding. 8 (3): 231–5. PMID 23924676.