Upstream open reading frame
An Upstream Open Reading Frame (uORF) is an Open Reading Frame (ORF) within the 5'UTR (5' untranslated region) of a mRNA. uORFs can regulate eukaryotic gene expression.[1][2] Translation of the uORF typically inhibits downstream expression of the primary ORF. In bacteria, uORFs are called leader peptides, and were originally discovered on the basis of their impact on the regulation of genes involved in the synthesis or transport of amino acids.
In humans, peptides derived from translated uORFs were detected with a mass spectrometer.[3]
See also
References
- ^ Vilela C, McCarthy JE (August 2003). "Regulation of fungal gene expression via short open reading frames in the mRNA 5'untranslated region". Mol. Microbiol. 49 (4): 859–67. doi:10.1046/j.1365-2958.2003.03622.x. PMID 12890013.
- ^ Lovett PS, Rogers EJ (June 1996). "Ribosome regulation by the nascent peptide". Microbiol. Rev. 60 (2): 366–85. PMC 239448. PMID 8801438.
- ^ Slavoff, Sarah A.; Mitchell, Andrew J.; Schwaid, Adam G.; Cabili, Moran N.; Ma, Jiao; Levin, Joshua Z.; Karger, Amir D.; Budnik, Bogdan A.; Rinn, John L. (2013-01-01). "Peptidomic discovery of short open reading frame-encoded peptides in human cells". Nature Chemical Biology. 9 (1): 59–64. doi:10.1038/nchembio.1120. ISSN 1552-4469. PMC 3625679. PMID 23160002.