Vimentin 3′ UTR protein-binding region
| Vimentin 3' UTR protein-binding region | |
|---|---|
 Predicted secondary structure and sequence conservation of Vimentin3 | |
| Identifiers | |
| Symbol | Vimentin3 |
| Rfam | RF00109 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000205 |
| PDB structures | PDBe |
The vimentin 3' UTR protein-binding region is an RNA element that contains a Y shaped structure which has been shown to have protein binding activity.[1] The same region has been implicated in the control of mRNA localisation to the perinuclear region of the cytoplasm, possibly at sites of intermediate filament assembly.[2] The identity of the proteins involved and the localisation mechanism are not known.
References
- ^ Zehner, ZE; Shepherd RK; Gabryszuk J; Fu TF; Al-Ali M; Holmes WM (1997). "RNA-protein interactions within the 3 ' untranslated region of vimentin mRNA". Nucleic Acids Res. 25 (16): 3362–3370. doi:10.1093/nar/25.16.3362. PMC 146884. PMID 9241253.
- ^ Bermano, G; Shepherd RK; Zehner ZE; Hesketh JE (2001). "Perinuclear mRNA localisation by vimentin 3'-untranslated region requires a 100 nucleotide sequence and intermediate filaments". FEBS Lett. 497 (2–3): 77–81. doi:10.1016/S0014-5793(01)02438-3. PMID 11377416.
External links
- Page for Vimentin 3' UTR protein-binding region at Rfam
- Transterm page for Vimentin Localisation Element
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