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ZXDC

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Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II.[1] For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein.[2] ZXDC is activated by sumolyation, a post-translational modification.[3]

References

  1. ^ Al-Kandari, W.; Jambunathan, S.; Navalgund, V.; Koneni, R.; Freer, M.; Parimi, N.; Mudhasani, R.; Fontes, J. D. (2007). "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription". Molecular Immunology. 44 (4): 311–321. doi:10.1016/j.molimm.2006.02.029. PMC 1624858. PMID 16600381.
  2. ^ Al-Kandari, W.; Koneni, R.; Navalgund, V.; Aleksandrova, A.; Jambunathan, S.; Fontes, J. D. (2007). "The Zinc Finger Proteins ZXDA and ZXDC Form a Complex that Binds CIITA and Regulates MHC II Gene Transcription". Journal of Molecular Biology. 369 (5): 1175–1187. doi:10.1016/j.jmb.2007.04.033. PMC 1963517. PMID 17493635.
  3. ^ Jambunathan, S.; Fontes, J. D. (2007). "Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain". Biological Chemistry. 388 (9): 965–972. doi:10.1515/BC.2007.106. PMID 17696781.


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