Zieve's syndrome

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Zieve's syndrome
Classification and external resources
ICD-10 K70.0
ICD-9-CM 571.1

Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged alcohol abuse. It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinaemia (excessive blood lipoprotein), jaundice, and abdominal pain.[1] The underlying cause is liver delipidization. This is distinct from alcoholic hepatitis which, however, may present simultaneously or develop later.


Zieve's syndrome was initially described in 1958.[2] Dr Leslie Zieve described patients with a combination of alcoholic liver disease, hemolytic anemia and hypertriglyceridemia.


  1. ^ Mehta, AB; N McIntyre (2004). Oxford Textbook of Clinical Hepatology. Oxford University Press. pp. 1786–1787. ISBN 0-19-262515-2. 
  2. ^ Zieve, L (March 1958). "Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis". Annals of Internal Medicine 48 (3): 471–476. doi:10.7326/0003-4819-48-3-471. PMID 13521581.