Macroketone
Appearance
Macroketones are macrocyclic compounds that contain a ketone functional group. Macroketones form the central rings systems of some synthetic polyketide antibiotics.[1][2]
References
[edit]- ^ Anquetin G, Horgan G, Rawe S, Murray D, Madden A, MacMathuna P, Doran P, Murphy PV (2008). "Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration". European Journal of Organic Chemistry. 2008 (11): 1953–1958. doi:10.1002/ejoc.200701192.
- ^ PDB: 3LNA; Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY (April 2010). "Migrastatin analogues target fascin to block tumour metastasis". Nature. 464 (7291): 1062–6. Bibcode:2010Natur.464.1062C. doi:10.1038/nature08978. PMC 2857318. PMID 20393565.
- "Anti-cancer Agent Stops Metastasis in its Tracks". Medical Xpress. April 14, 2010.