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Phenylethylmalonamide

From Wikipedia, the free encyclopedia
Phenylethylmalonamide
Names
Preferred IUPAC name
2-Ethyl-2-phenylpropanediamide
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.027.804 Edit this at Wikidata
UNII
  • InChI=1S/C11H14N2O2/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15) ☒N
    Key: JFZHPFOXAAIUMB-UHFFFAOYSA-N ☒N
  • InChI=1/C11H14N2O2/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15)
    Key: JFZHPFOXAAIUMB-UHFFFAOYAN
  • CCC(c1ccccc1)(C(=O)N)C(=O)N
Properties
C11H14N2O2
Molar mass 206.24 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phenylethylmalonamide (PEMA) is an active metabolite of the anticonvulsant drug primidone, although it is produced in a much lower concentration than phenobarbital, the other active metabolite.[1]

References

[edit]
  1. ^ El-Masri HA, Portier CJ (June 1998). "Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice". Drug Metab. Dispos. 26 (6): 585–94. PMID 9616196.