Drug titration: Difference between revisions
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'''Drug titration''' is the process of adjusting the [[dosing|dose]] of a [[medication]] for the maximum benefit without [[adverse effects]]. Some examples of the types of drugs commonly requiring titration include [[insulin]], [[anticonvulsant]]s, [[blood thinner]]s, [[anti-depressant]]s, and [[sedative]]s.<ref>{{cite book | vauthors = Roden DM | chapter = Chapter 5 : Principles of Clinical Pharmacology | veditors = Kasper D, Fauci A, Hauser S, Longo D,Jameson JL, Loscalzo J | title = Principles of Clinical Pharmacology | edition = 19th | isbn = 978-0-07-180215-4 | location = New York, NY | publisher = McGraw-Hill | date = 2014 }}</ref><ref>{{cite book | veditors = Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AH | chapter = Section III: Therapeutic Drugs and Antidotes | title = Poisoning & Drug Overdose | edition = 7th | isbn = 978-0-07-183979-2 | location = New York, NY | publisher = McGraw-Hill }}</ref><ref>{{cite book | vauthors = Kruidering-Hall M, Campbell L | chapter = Chapter 27: Skeletal Muscle Relaxants | veditors = Katzung BG | title = Basic & Clinical Pharmacology | edition = 14th | location = New York, NY | publisher = McGraw-Hill | isbn = 978-1-259-64115-2 }}</ref> |
'''Drug titration''' is the process of adjusting the [[dosing|dose]] of a [[medication]] for the maximum benefit without [[adverse effects]].<ref>{{cite book | vauthors = Maxwell S | veditors = Walker BR, Colledge NR, Ralston SH, Penman ID | chapter = Chapter 2: Therapeutics and Good Prescribing: Choosing a Dosing Regime | title = Davidson's Principles and Practice of Medicine |date=2013 |publisher=Elsevier Health Sciences |isbn=978-0-7020-5103-6 |pages=34 | chapter-url = https://books.google.com/books?id=W-5kAgAAQBAJ&pg=PA34 }}</ref> Some examples of the types of drugs commonly requiring titration include [[insulin]], [[anticonvulsant]]s, [[blood thinner]]s, [[anti-depressant]]s, and [[sedative]]s.<ref>{{cite book | vauthors = Roden DM | chapter = Chapter 5 : Principles of Clinical Pharmacology | veditors = Kasper D, Fauci A, Hauser S, Longo D,Jameson JL, Loscalzo J | title = Principles of Clinical Pharmacology | edition = 19th | isbn = 978-0-07-180215-4 | location = New York, NY | publisher = McGraw-Hill | date = 2014 }}</ref><ref>{{cite book | veditors = Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AH | chapter = Section III: Therapeutic Drugs and Antidotes | title = Poisoning & Drug Overdose | edition = 7th | isbn = 978-0-07-183979-2 | location = New York, NY | publisher = McGraw-Hill }}</ref><ref>{{cite book | vauthors = Kruidering-Hall M, Campbell L | chapter = Chapter 27: Skeletal Muscle Relaxants | veditors = Katzung BG | title = Basic & Clinical Pharmacology | edition = 14th | location = New York, NY | publisher = McGraw-Hill | isbn = 978-1-259-64115-2 }}</ref> |
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Titrating off of a medical instead of stopping abruptly is recommended in some situations. [[Glucocorticoid]]s should be tapered after extended use to avoid adrenal insufficiency.<ref>{{cite book | vauthors = Furst DE, Saag KG | veditors = Matteson EL, Curtis MR | chapter = Glucocorticoid withdrawl | title = Treatment Issues in Rheumatology | chapter-url=https://www.uptodate.com/contents/glucocorticoid-withdrawal | website = UpToDate |accessdate=13 June 2018}}</ref> |
Titrating off of a medical instead of stopping abruptly is recommended in some situations. [[Glucocorticoid]]s should be tapered after extended use to avoid adrenal insufficiency.<ref>{{cite book | vauthors = Furst DE, Saag KG | veditors = Matteson EL, Curtis MR | chapter = Glucocorticoid withdrawl | title = Treatment Issues in Rheumatology | chapter-url=https://www.uptodate.com/contents/glucocorticoid-withdrawal | website = UpToDate |accessdate=13 June 2018}}</ref> |
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Revision as of 09:25, 14 June 2018
Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects.[1] Some examples of the types of drugs commonly requiring titration include insulin, anticonvulsants, blood thinners, anti-depressants, and sedatives.[2][3][4]
Titrating off of a medical instead of stopping abruptly is recommended in some situations. Glucocorticoids should be tapered after extended use to avoid adrenal insufficiency.[5]
Drug titration is also used in phase I of clinical trials. The experimental drug is given in increasing dosages until side effects become intolerable.[6] A clinical trial in which a suitable dose is found is called a dose-ranging study.
References
- ^ Maxwell S (2013). "Chapter 2: Therapeutics and Good Prescribing: Choosing a Dosing Regime". In Walker BR, Colledge NR, Ralston SH, Penman ID (eds.). Davidson's Principles and Practice of Medicine. Elsevier Health Sciences. p. 34. ISBN 978-0-7020-5103-6.
- ^ Roden DM (2014). "Chapter 5 : Principles of Clinical Pharmacology". In Kasper D, Fauci A, Hauser S, Longo D, Jameson JL, Loscalzo J (eds.). Principles of Clinical Pharmacology (19th ed.). New York, NY: McGraw-Hill. ISBN 978-0-07-180215-4.
- ^ Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AH (eds.). "Section III: Therapeutic Drugs and Antidotes". Poisoning & Drug Overdose (7th ed.). New York, NY: McGraw-Hill. ISBN 978-0-07-183979-2.
- ^ Kruidering-Hall M, Campbell L. "Chapter 27: Skeletal Muscle Relaxants". In Katzung BG (ed.). Basic & Clinical Pharmacology (14th ed.). New York, NY: McGraw-Hill. ISBN 978-1-259-64115-2.
- ^ Furst DE, Saag KG. "Glucocorticoid withdrawl". In Matteson EL, Curtis MR (eds.). Treatment Issues in Rheumatology. Retrieved 13 June 2018.
{{cite book}}:|website=ignored (help) - ^ "Dose-Response Information to Support Drug Registration" (PDF). Guideline for Industry. FDA. November 1994. Retrieved 13 June 2018.