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Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant. Opioids work in the brain to produce a variety...222 KB (19,669 words) - 18:52, 20 August 2024
The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled receptor that in humans is encoded...67 KB (7,676 words) - 03:02, 15 August 2024
Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins...40 KB (4,427 words) - 12:37, 12 January 2024
Opioid withdrawal is a set of symptoms (a syndrome) arising from the sudden withdrawal or reduction of opioids where previous usage has been heavy and...14 KB (1,582 words) - 02:57, 21 August 2024
There is an ongoing opioid epidemic (also known as the opioid crisis) in the United States, originating out of both medical prescriptions and illegal...249 KB (25,741 words) - 03:54, 19 August 2024
An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, and methadone. This preventable...52 KB (5,456 words) - 21:41, 28 August 2024
The opioid epidemic, also referred to as the opioid crisis, is the rapid increase in the overuse, misuse/abuse, and overdose deaths attributed either...79 KB (8,422 words) - 20:04, 27 August 2024
The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins...22 KB (2,424 words) - 08:47, 18 May 2024
An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors. Naloxone and naltrexone...11 KB (1,340 words) - 14:34, 24 July 2024
Naloxone (category Kappa-opioid receptor antagonists)an opioid antagonist: a medication used to reverse or reduce the effects of opioids. For example, it is used to restore breathing after an opioid overdose...82 KB (7,456 words) - 00:15, 27 August 2024- Opioid use disorder (OUD) is a substance use disorder characterized by cravings for opioids, continued use despite physical and/or psychological deterioration...125 KB (13,338 words) - 05:49, 24 August 2024
Naltrexone (category Delta-opioid receptor antagonists)Revia among others, is a medication primarily used to manage alcohol use or opioid use disorder by reducing cravings and feelings of euphoria associated with...107 KB (10,594 words) - 02:44, 4 September 2024
pain. These fulfilled criteria include a suitable nervous system and sensory receptors; opioid receptors and reduced responses to noxious stimuli when given...68 KB (7,778 words) - 14:22, 28 June 2024
Buprenorphine (category Delta-opioid receptor antagonists)Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under...81 KB (7,327 words) - 15:27, 16 August 2024- Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with Opioid use disorder (OUD). In the case...33 KB (4,049 words) - 07:48, 10 June 2024
- systems to be explored when trying to look for a neurochemical relationship between pain and pleasure are the opioid and dopamine systems. The opioid...23 KB (2,802 words) - 14:19, 22 August 2024
like morphine also interacts directly with the endogenous opioid system by binding at opioid receptor binding sites. Conversely, α2-adrenoceptor antagonists...96 KB (10,049 words) - 11:48, 26 August 2024
occurs in surrounding undamaged tissues. Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain. Various...16 KB (1,854 words) - 13:05, 27 August 2024- characterized by abnormal behavior of the endogenous opioid system but not the monoaminergic system. Symptoms vary in severity, type, and frequency and...10 KB (1,116 words) - 20:53, 19 August 2024
Publishing. PMID 30570984. The Opioid System as the Interface between the Brain's Cognitive and Motivational Systems. Academic Press. 2018. p. 73....68 KB (6,431 words) - 03:17, 2 September 2024
- the National Drug Demand and Opioid Crisis 2365400Presidential Memorandum — Combatting the National Drug Demand and Opioid Crisis2017Donald John Trump
- opioids increased 45 percent from 2016 to 2017, and in 2017, more than 70,000 people died from drug overdoses—68 percent of which involved an opioid.
- Opioids are painkillers commonly prescribed in the United States of America. The 'opioid epidemic' refers to large scale over prescription of and addiction