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{{short description|Association of blood lead levels with criminal behavior}}
{{short description|Association of blood lead levels with criminal behavior}}
{{use mdy dates |date=April 2021}}
[[File:Gas pump lead warning.jpg|thumb|right|300px|An American fuel pump that dispensed [[gasoline]] with [[tetraethyllead]] additives.]]
[[File:Gas pump lead warning.jpg|thumb|right|300px|An American fuel pump that dispensed [[gasoline]] with [[tetraethyllead]] additives.]]


The '''lead–crime hypothesis''' is the association between elevated [[blood lead level]]s in children and increased rates of crime, delinquency, and recidivism later in life.<ref name=":4">{{Cite journal|last=Stretesky|first=Paul B.|last2=Lynch|first2=Michael J.|date=2004|title=The Relationship between Lead and Crime|journal=Journal of Health and Social Behavior|volume=45|issue=2|pages=214–229|doi=10.1177/002214650404500207|pmid=15305761|issn=0022-1465}}</ref><ref>{{Cite journal|last=Nevin|first=Rick|date=2007|title=Understanding international crime trends: The legacy of preschool lead exposure|journal=Environmental Research|volume=104|issue=3|pages=315–336|doi=10.1016/j.envres.2007.02.008|pmid=17451672|issn=0013-9351|bibcode=2007ER....104..315N|url=https://mpra.ub.uni-muenchen.de/35338/1/MPRA_paper_35338.pdf}}</ref><ref name=":5">{{Cite journal|last=Marcus|first=David K.|last2=Fulton|first2=Jessica J.|last3=Clarke|first3=Erin J.|date=2010-02-26|title=Lead and Conduct Problems: A Meta-Analysis|journal=Journal of Clinical Child & Adolescent Psychology|volume=39|issue=2|pages=234–241|doi=10.1080/15374411003591455|pmid=20390814|issn=1537-4416}}</ref><ref name=":6">{{Cite journal|last=Wright|first=John Paul|last2=Dietrich|first2=Kim N|last3=Ris|first3=M. Douglas|last4=Hornung|first4=Richard W|last5=Wessel|first5=Stephanie D|last6=Lanphear|first6=Bruce P|last7=Ho|first7=Mona|last8=Rae|first8=Mary N|date=2008-05-27|title=Association of Prenatal and Childhood Blood Lead Concentrations with Criminal Arrests in Early Adulthood|journal=PLoS Medicine|volume=5|issue=5|pages=e101|doi=10.1371/journal.pmed.0050101|pmid=18507497|pmc=2689664|issn=1549-1676}}</ref><ref>{{cite web |url=https://www.firstcoastnews.com/article/news/local/jacksonville-florida-attorney-says-lead-poisoning-may-explain-some-criminal-behavior/77-5a01b4fe-e96a-4f9a-96b9-01fad2915543 |title=Jacksonville attorney says lead poisoning may explain some criminal behavior |last=Amaro |first=Ken |date=March 23, 2021 |website=First Coast News WTLV-WJXX |publisher=TEGNA and NBC |access-date=March 29, 2021 |quote=Now, environmental hazards like lead poisoning are being included in the mitigation package to win mercy and a reduced sentence.}}</ref><ref>{{cite web |url=https://jjie.org/2021/03/22/florida-attorney-believes-lead-poisoning-is-partial-explanation-for-low-income-neighborhood-crimes/ |title=Florida Attorney Believes Lead Poisoning Is Partial Explanation For Low-income Neighborhood Crimes |last=Goforth |first=Claire |date=March 22, 2021 |website=Institute for Nonprofit News. |publisher=Juvenile Justice Information Exchange |access-date=March 29, 2021 |quote=Much of the evidence to reduce his sentence, known as a mitigation package, is familiar to people in the criminal justice field — child abuse, abandonment, poverty and, of course, youth. One argument stands out from the rest: lead poisoning.}}</ref>
The '''lead–crime hypothesis''' is the association between elevated [[blood lead level]]s in children and increased rates of crime, delinquency, and recidivism later in life.<ref name=":4">{{Cite journal|last1=Stretesky|first1=Paul B.|last2=Lynch|first2=Michael J.|date=2004|title=The Relationship between Lead and Crime|journal=Journal of Health and Social Behavior|volume=45|issue=2|pages=214–229|doi=10.1177/002214650404500207|pmid=15305761|s2cid=38272708|issn=0022-1465}}</ref><ref>{{Cite journal|last=Nevin|first=Rick|date=2007|title=Understanding international crime trends: The legacy of preschool lead exposure|journal=Environmental Research|volume=104|issue=3|pages=315–336|doi=10.1016/j.envres.2007.02.008|pmid=17451672|issn=0013-9351|bibcode=2007ER....104..315N|url=https://mpra.ub.uni-muenchen.de/35338/1/MPRA_paper_35338.pdf}}</ref><ref name=":5">{{Cite journal|last1=Marcus|first1=David K.|last2=Fulton|first2=Jessica J.|last3=Clarke|first3=Erin J.|date=2010-02-26|title=Lead and Conduct Problems: A Meta-Analysis|journal=Journal of Clinical Child & Adolescent Psychology|volume=39|issue=2|pages=234–241|doi=10.1080/15374411003591455|pmid=20390814|s2cid=30765610|issn=1537-4416}}</ref><ref name=":6">{{Cite journal|last1=Wright|first1=John Paul|last2=Dietrich|first2=Kim N|last3=Ris|first3=M. Douglas|last4=Hornung|first4=Richard W|last5=Wessel|first5=Stephanie D|last6=Lanphear|first6=Bruce P|last7=Ho|first7=Mona|last8=Rae|first8=Mary N|date=2008-05-27|title=Association of Prenatal and Childhood Blood Lead Concentrations with Criminal Arrests in Early Adulthood|journal=PLOS Medicine|volume=5|issue=5|pages=e101|doi=10.1371/journal.pmed.0050101|pmid=18507497|pmc=2689664|issn=1549-1676}}</ref><ref>{{cite web |url=https://www.firstcoastnews.com/article/news/local/jacksonville-florida-attorney-says-lead-poisoning-may-explain-some-criminal-behavior/77-5a01b4fe-e96a-4f9a-96b9-01fad2915543 |title=Jacksonville attorney says lead poisoning may explain some criminal behavior |last=Amaro |first=Ken |date=March 23, 2021 |website=First Coast News WTLV-WJXX |publisher=TEGNA and NBC |access-date=March 29, 2021 |quote=Now, environmental hazards like lead poisoning are being included in the mitigation package to win mercy and a reduced sentence.}}</ref><ref>{{cite web |url=https://jjie.org/2021/03/22/florida-attorney-believes-lead-poisoning-is-partial-explanation-for-low-income-neighborhood-crimes/ |title=Florida Attorney Believes Lead Poisoning Is Partial Explanation For Low-income Neighborhood Crimes |last=Goforth |first=Claire |date=March 22, 2021 |website=Institute for Nonprofit News. |publisher=Juvenile Justice Information Exchange |access-date=March 29, 2021 |quote=Much of the evidence to reduce his sentence, known as a mitigation package, is familiar to people in the criminal justice field — child abuse, abandonment, poverty and, of course, youth. One argument stands out from the rest: lead poisoning.}}</ref>


Lead is widely understood to be highly [[Lead poisoning|toxic]] to multiple organs of the body,<ref>{{Cite web|url=https://www.atsdr.cdc.gov/csem/csem.asp?csem=34&po=0|title=Lead (Pb) Toxicity: Key Concepts {{!}} ATSDR - Environmental Medicine & Environmental Health Education - CSEM|last=ATSDR|website=www.atsdr.cdc.gov|language=en-US|access-date=2018-10-18}}</ref> particularly the [[brain]].<ref name=":2">{{Cite journal|last=Stewart|first=W. F.|last2=Schwartz|first2=B. S.|last3=Davatzikos|first3=C.|last4=Shen|first4=D.|last5=Liu|first5=D.|last6=Wu|first6=X.|last7=Todd|first7=A. C.|last8=Shi|first8=W.|last9=Bassett|first9=S.|date=2006-05-22|title=Past adult lead exposure is linked to neurodegeneration measured by brain MRI|journal=Neurology|volume=66|issue=10|pages=1476–1484|doi=10.1212/01.wnl.0000216138.69777.15|pmid=16717205|issn=0028-3878|citeseerx=10.1.1.408.1953}}</ref><ref name=":3">{{Cite journal|last=Cecil|first=Kim M|last2=Brubaker|first2=Christopher J|last3=Adler|first3=Caleb M|last4=Dietrich|first4=Kim N|last5=Altaye|first5=Mekibib|last6=Egelhoff|first6=John C|last7=Wessel|first7=Stephanie|last8=Elangovan|first8=Ilayaraja|last9=Hornung|first9=Richard|date=2008-05-27|title=Decreased Brain Volume in Adults with Childhood Lead Exposure|journal=PLoS Medicine|volume=5|issue=5|pages=e112|doi=10.1371/journal.pmed.0050112|pmid=18507499|pmc=2689675|issn=1549-1676}}</ref><ref>{{Cite journal|last=Sanders|first=T.|last2=Liu|first2=Y.|last3=Buchner|first3=V.|last4=Tchounwou|first4=P.B.|date=January 2009|title=Neurotoxic Effects and Biomarkers of Lead Exposure: A Review|journal=Reviews on Environmental Health|volume=24|issue=1|pages=15–45|doi=10.1515/reveh.2009.24.1.15|pmc=2858639|issn=2191-0308|pmid=19476290}}</ref> Individuals exposed to [[lead]] at young ages are more vulnerable to [[learning disabilities]],<ref>{{Cite journal|last=Leviton|first=A.|last2=Bellinger|first2=D.|last3=Allred|first3=E.N.|last4=Rabinowitz|first4=M.|last5=Needleman|first5=H.|last6=Schoenbaum|first6=S.|date=1993|title=Pre- and Postnatal Low-Level Lead Exposure and Children′s Dysfunction in School|journal=Environmental Research|volume=60|issue=1|pages=30–43|doi=10.1006/enrs.1993.1003|pmid=7679348|issn=0013-9351|bibcode=1993ER.....60...30L}}</ref><ref>{{Citation|last=Caito|first=Samuel|title=Developmental Neurotoxicity of Lead|volume=18|date=2017|journal=Advances in Neurobiology|pages=3–12|publisher=Springer International Publishing|isbn=9783319601885|last2=Aschner|first2=Michael|doi=10.1007/978-3-319-60189-2_1|pmid=28889260}}</ref> decreased [[Intelligence quotient|I.Q.]],<ref>{{Cite journal|last=Lanphear|first=Bruce P.|last2=Hornung|first2=Richard|last3=Khoury|first3=Jane|last4=Yolton|first4=Kimberly|last5=Baghurst|first5=Peter|last6=Bellinger|first6=David C.|last7=Canfield|first7=Richard L.|last8=Dietrich|first8=Kim N.|last9=Bornschein|first9=Robert|date=2005|title=Low-Level Environmental Lead Exposure and Children's Intellectual Function: An International Pooled Analysis|journal=Environmental Health Perspectives|volume=113|issue=7|pages=894–899|doi=10.1289/ehp.7688|pmid=16002379|pmc=1257652|issn=0091-6765}}</ref> [[attention deficit hyperactivity disorder]],<ref>{{Cite book|title=Exposures to Environmental Toxicants and Attention Deficit Hyperactivity Disorder in U.S. Children|last=P.|first=Braun, Joe M. Kahn, Robert S. Froehlich, Tanya Auinger, Peggy Lanphear, Bruce|date=2006|publisher=National Institute of Environmental Health Sciences|oclc=678275247}}</ref><ref>{{Cite journal|last=Bellinger|first=David C|date=2008-05-27|title=Neurological and Behavioral Consequences of Childhood Lead Exposure|journal=PLoS Medicine|volume=5|issue=5|pages=e115|doi=10.1371/journal.pmed.0050115|pmid=18507501|pmc=2689677|issn=1549-1676}}</ref> and problems with [[impulse control]],<ref>{{Cite journal|last=Liu|first=Jianghong|date=2011|title=Early health risk factors for violence: Conceptualization, evidence, and implications|journal=Aggression and Violent Behavior|volume=16|issue=1|pages=63–73|doi=10.1016/j.avb.2010.12.003|pmid=21399727|pmc=3052794|issn=1359-1789}}</ref> all of which may be negatively impacting decision making and leading to the commission of more crimes as these children reach adulthood, especially [[violent crime]]s.<ref>{{Cite journal|last=Olympio|first=Kelly Polido Kaneshiro|last2=Gonçalves|first2=Claudia|last3=Günther|first3=Wanda Maria Risso|last4=Bechara|first4=Etelvino José Henriques|date=2009|title=Neurotoxicity and aggressiveness triggered by low-level lead in children: a review|journal=Revista Panamericana de Salud Pública|volume=26|issue=3|pages=266–75|doi=10.1590/s1020-49892009000900011|pmid=20058837|issn=1020-4989|doi-access=free}}</ref> No safe level of lead in the human bloodstream exists given that any amount can contribute to deleterious health issues.<ref name=Pediatrics/>
Lead is widely understood to be highly [[Lead poisoning|toxic]] to multiple organs of the body,<ref>{{Cite web|url=https://www.atsdr.cdc.gov/csem/csem.asp?csem=34&po=0|title=Lead (Pb) Toxicity: Key Concepts {{!}} ATSDR - Environmental Medicine & Environmental Health Education - CSEM|last=ATSDR|website=www.atsdr.cdc.gov|language=en-US|access-date=2018-10-18}}</ref> particularly the [[brain]].<ref name=":2">{{Cite journal|last1=Stewart|first1=W. F.|last2=Schwartz|first2=B. S.|last3=Davatzikos|first3=C.|last4=Shen|first4=D.|last5=Liu|first5=D.|last6=Wu|first6=X.|last7=Todd|first7=A. C.|last8=Shi|first8=W.|last9=Bassett|first9=S.|date=2006-05-22|title=Past adult lead exposure is linked to neurodegeneration measured by brain MRI|journal=Neurology|volume=66|issue=10|pages=1476–1484|doi=10.1212/01.wnl.0000216138.69777.15|pmid=16717205|issn=0028-3878|citeseerx=10.1.1.408.1953|s2cid=14946219}}</ref><ref name=":3">{{Cite journal|last1=Cecil|first1=Kim M|last2=Brubaker|first2=Christopher J|last3=Adler|first3=Caleb M|last4=Dietrich|first4=Kim N|last5=Altaye|first5=Mekibib|last6=Egelhoff|first6=John C|last7=Wessel|first7=Stephanie|last8=Elangovan|first8=Ilayaraja|last9=Hornung|first9=Richard|date=2008-05-27|title=Decreased Brain Volume in Adults with Childhood Lead Exposure|journal=PLOS Medicine|volume=5|issue=5|pages=e112|doi=10.1371/journal.pmed.0050112|pmid=18507499|pmc=2689675|issn=1549-1676}}</ref><ref>{{Cite journal|last1=Sanders|first1=T.|last2=Liu|first2=Y.|last3=Buchner|first3=V.|last4=Tchounwou|first4=P.B.|date=January 2009|title=Neurotoxic Effects and Biomarkers of Lead Exposure: A Review|journal=Reviews on Environmental Health|volume=24|issue=1|pages=15–45|doi=10.1515/reveh.2009.24.1.15|pmc=2858639|issn=2191-0308|pmid=19476290}}</ref> Individuals exposed to [[lead]] at young ages are more vulnerable to [[learning disabilities]],<ref>{{Cite journal|last1=Leviton|first1=A.|last2=Bellinger|first2=D.|last3=Allred|first3=E.N.|last4=Rabinowitz|first4=M.|last5=Needleman|first5=H.|last6=Schoenbaum|first6=S.|date=1993|title=Pre- and Postnatal Low-Level Lead Exposure and Children′s Dysfunction in School|journal=Environmental Research|volume=60|issue=1|pages=30–43|doi=10.1006/enrs.1993.1003|pmid=7679348|issn=0013-9351|bibcode=1993ER.....60...30L}}</ref><ref>{{Citation|last1=Caito|first1=Samuel|title=Developmental Neurotoxicity of Lead|volume=18|date=2017|journal=Advances in Neurobiology|pages=3–12|publisher=Springer International Publishing|isbn=9783319601885|last2=Aschner|first2=Michael|doi=10.1007/978-3-319-60189-2_1|pmid=28889260}}</ref> decreased [[Intelligence quotient|I.Q.]],<ref>{{Cite journal|last1=Lanphear|first1=Bruce P.|last2=Hornung|first2=Richard|last3=Khoury|first3=Jane|last4=Yolton|first4=Kimberly|last5=Baghurst|first5=Peter|last6=Bellinger|first6=David C.|last7=Canfield|first7=Richard L.|last8=Dietrich|first8=Kim N.|last9=Bornschein|first9=Robert|date=2005|title=Low-Level Environmental Lead Exposure and Children's Intellectual Function: An International Pooled Analysis|journal=Environmental Health Perspectives|volume=113|issue=7|pages=894–899|doi=10.1289/ehp.7688|pmid=16002379|pmc=1257652|issn=0091-6765}}</ref> [[attention deficit hyperactivity disorder]],<ref>{{Cite journal|title=Exposures to Environmental Toxicants and Attention Deficit Hyperactivity Disorder in U.S. Children|last=P.|first=Braun, Joe M. Kahn, Robert S. Froehlich, Tanya Auinger, Peggy Lanphear, Bruce|journal=Environmental Health Perspectives|date=2006|volume=114|issue=12|pages=1904–1909|publisher=National Institute of Environmental Health Sciences|doi=10.1289/ehp.9478|pmid=17185283|pmc=1764142|oclc=678275247}}</ref><ref>{{Cite journal|last=Bellinger|first=David C|date=2008-05-27|title=Neurological and Behavioral Consequences of Childhood Lead Exposure|journal=PLOS Medicine|volume=5|issue=5|pages=e115|doi=10.1371/journal.pmed.0050115|pmid=18507501|pmc=2689677|issn=1549-1676}}</ref> and problems with [[impulse control]],<ref>{{Cite journal|last=Liu|first=Jianghong|date=2011|title=Early health risk factors for violence: Conceptualization, evidence, and implications|journal=Aggression and Violent Behavior|volume=16|issue=1|pages=63–73|doi=10.1016/j.avb.2010.12.003|pmid=21399727|pmc=3052794|issn=1359-1789}}</ref> all of which may be negatively impacting decision making and leading to the commission of more crimes as these children reach adulthood, especially [[violent crime]]s.<ref>{{Cite journal|last1=Olympio|first1=Kelly Polido Kaneshiro|last2=Gonçalves|first2=Claudia|last3=Günther|first3=Wanda Maria Risso|last4=Bechara|first4=Etelvino José Henriques|date=2009|title=Neurotoxicity and aggressiveness triggered by low-level lead in children: a review|journal=Revista Panamericana de Salud Pública|volume=26|issue=3|pages=266–75|doi=10.1590/s1020-49892009000900011|pmid=20058837|issn=1020-4989|doi-access=free}}</ref> No safe level of lead in the human bloodstream exists given that any amount can contribute to deleterious health issues.<ref name=Pediatrics/>


Proponents of the lead–crime hypothesis argue that the removal of [[Tetraethyllead#In motor fuel|lead additives from motor fuel]], and the consequent decline in children's lead exposure, explains [[Crime drop|the fall]] in [[crime rates in the United States]] beginning in the 1990s.{{refn|name=Doleac}} This hypothesis also offers an explanation of the earlier rise in crime in the preceding decades as the result of increased lead exposure throughout the mid-20th century.<ref name="Steel">{{cite book |last1=Steel |first1=Daniel |display-editors=etal |editor1-last=Chao |editor1-first=Hsiang-Ke |title=Mechanism and Causality in Biology and Economics |date=2013 |publisher=Springer Science & Business Media |isbn=978-9-40-072454-9 |page=188 |chapter-url=https://books.google.com/books?id=Bf40AAAAQBAJ&pg=PA188&dq=lead |chapter=Mechanisms and Extrapolation in the Abortion-Crime Controversy}}</ref>
Proponents of the lead–crime hypothesis argue that the removal of [[Tetraethyllead#In motor fuel|lead additives from motor fuel]], and the consequent decline in children's lead exposure, explains [[Crime drop|the fall]] in [[crime rates in the United States]] beginning in the 1990s.{{refn|name=Doleac}} This hypothesis also offers an explanation of the earlier rise in crime in the preceding decades as the result of increased lead exposure throughout the mid-20th century.<ref name="Steel">{{cite book |last1=Steel |first1=Daniel |display-editors=etal |editor1-last=Chao |editor1-first=Hsiang-Ke |title=Mechanism and Causality in Biology and Economics |date=2013 |publisher=Springer Science & Business Media |isbn=978-9-40-072454-9 |page=188 |chapter-url=https://books.google.com/books?id=Bf40AAAAQBAJ&q=lead&pg=PA188 |chapter=Mechanisms and Extrapolation in the Abortion-Crime Controversy}}</ref>


The lead–crime hypothesis is not mutually exclusive with other explanations of the drop in US crime rates<ref>{{Cite journal|last=Farrell|first=Graham|last2=Tilley|first2=Nick|last3=Tseloni|first3=Andromachi|date=2014|title=Why the Crime Drop?|journal=Crime and Justice|volume=43|issue=1|pages=421–490|doi=10.1086/678081|issn=0192-3234|url=http://eprints.whiterose.ac.uk/97466/1/Farrell%20Tilley%20Tseloni%202014%20Why%20the%20Crime%20Drop%20%28C%26J%20vol43%29.pdf}}</ref><ref>{{Cite journal|last=Levitt|first=Steven D|date=2004|title=Understanding Why Crime Fell in the 1990s: Four Factors that Explain the Decline and Six that Do Not|journal=Journal of Economic Perspectives|volume=18|issue=1|pages=163–190|doi=10.1257/089533004773563485|issn=0895-3309|citeseerx=10.1.1.210.3073}}</ref> such as the [[legalized abortion and crime effect]].<ref>{{Cite journal|last=Donohue|first=J. J.|last2=Levitt|first2=S. D.|date=2001-05-01|title=The Impact of Legalized Abortion on Crime|journal=The Quarterly Journal of Economics|volume=116|issue=2|pages=379–420|doi=10.1162/00335530151144050|issn=0033-5533|citeseerx=10.1.1.205.9648}}</ref> Lead exposure during the years in question correlated with exposure to urban [[poverty]], due to close residential or primary school proximity with high-density motor vehicle traffic burning leaded gasoline or from residing in older, poorly maintained housing stock, much of which contained high levels of lead in the form of lead paint, lead solder, or other lead-based building materials; additionally, municipalities with a low taxation base often continued to receive drinking water via degraded lead pipes rather than upgrading to modern infrastructure. The difficulty in measuring the effect of lead exposure on crime rates lies in separating the effect from other indicators of low [[socioeconomic status]] such as poorer schools, nutrition, and medical care, exposure to other pollutants, and other variables that are predictive of criminal behavior.<ref>{{Cite journal|last=Ludwig|first=J.|last2=Duncan|first2=G. J.|last3=Hirschfield|first3=P.|date=2001-05-01|title=Urban Poverty and Juvenile Crime: Evidence from a Randomized Housing-Mobility Experiment|journal=The Quarterly Journal of Economics|volume=116|issue=2|pages=655–679|doi=10.1162/00335530151144122|issn=0033-5533|url=https://semanticscholar.org/paper/a44400d77440e4ec9c80eaa75642b8406820f1a8}}</ref><ref>{{Cite journal|last=Hsieh|first=Ching-Chi|last2=Pugh|first2=M. D.|date=1993|title=Poverty, Income Inequality, and Violent Crime: A Meta-Analysis of Recent Aggregate Data Studies|journal=Criminal Justice Review|volume=18|issue=2|pages=182–202|doi=10.1177/073401689301800203|issn=0734-0168}}</ref><ref>{{Cite journal|last=Cantor|first=David|last2=Land|first2=Kenneth C.|date=1985|title=Unemployment and Crime Rates in the Post-World War II United States: A Theoretical and Empirical Analysis|journal=American Sociological Review|volume=50|issue=3|pages=317|doi=10.2307/2095542|issn=0003-1224|jstor=2095542}}</ref><ref>{{cite journal | last1 = Werbach | first1 = M | year = 1992 | title = Nutritional influences on aggressive behavior | journal = J Orthomol Med | volume = 7 | issue = 1| pages = 45–51 }}</ref>
The lead–crime hypothesis is not mutually exclusive with other explanations of the drop in US crime rates<ref>{{Cite journal|last1=Farrell|first1=Graham|last2=Tilley|first2=Nick|last3=Tseloni|first3=Andromachi|date=2014|title=Why the Crime Drop?|journal=Crime and Justice|volume=43|issue=1|pages=421–490|doi=10.1086/678081|s2cid=145719976|issn=0192-3234|url=http://eprints.whiterose.ac.uk/97466/1/Farrell%20Tilley%20Tseloni%202014%20Why%20the%20Crime%20Drop%20%28C%26J%20vol43%29.pdf}}</ref><ref>{{Cite journal|last=Levitt|first=Steven D|date=2004|title=Understanding Why Crime Fell in the 1990s: Four Factors that Explain the Decline and Six that Do Not|journal=Journal of Economic Perspectives|volume=18|issue=1|pages=163–190|doi=10.1257/089533004773563485|issn=0895-3309|citeseerx=10.1.1.210.3073}}</ref> such as the [[legalized abortion and crime effect]].<ref>{{Cite journal|last1=Donohue|first1=J. J.|last2=Levitt|first2=S. D.|date=2001-05-01|title=The Impact of Legalized Abortion on Crime|journal=The Quarterly Journal of Economics|volume=116|issue=2|pages=379–420|doi=10.1162/00335530151144050|issn=0033-5533|citeseerx=10.1.1.205.9648}}</ref> Lead exposure during the years in question correlated with exposure to urban [[poverty]], due to close residential or primary school proximity with high-density motor vehicle traffic burning leaded gasoline or from residing in older, poorly maintained housing stock, much of which contained high levels of lead in the form of lead paint, lead solder, or other lead-based building materials; additionally, municipalities with a low taxation base often continued to receive drinking water via degraded lead pipes rather than upgrading to modern infrastructure. The difficulty in measuring the effect of lead exposure on crime rates lies in separating the effect from other indicators of low [[socioeconomic status]] such as poorer schools, nutrition, and medical care, exposure to other pollutants, and other variables that are predictive of criminal behavior.<ref>{{Cite journal|last1=Ludwig|first1=J.|last2=Duncan|first2=G. J.|last3=Hirschfield|first3=P.|date=2001-05-01|title=Urban Poverty and Juvenile Crime: Evidence from a Randomized Housing-Mobility Experiment|journal=The Quarterly Journal of Economics|volume=116|issue=2|pages=655–679|doi=10.1162/00335530151144122|s2cid=7372118|issn=0033-5533|url=https://semanticscholar.org/paper/a44400d77440e4ec9c80eaa75642b8406820f1a8}}</ref><ref>{{Cite journal|last1=Hsieh|first1=Ching-Chi|last2=Pugh|first2=M. D.|date=1993|title=Poverty, Income Inequality, and Violent Crime: A Meta-Analysis of Recent Aggregate Data Studies|journal=Criminal Justice Review|volume=18|issue=2|pages=182–202|doi=10.1177/073401689301800203|s2cid=146740046|issn=0734-0168}}</ref><ref>{{Cite journal|last1=Cantor|first1=David|last2=Land|first2=Kenneth C.|date=1985|title=Unemployment and Crime Rates in the Post-World War II United States: A Theoretical and Empirical Analysis|journal=American Sociological Review|volume=50|issue=3|pages=317|doi=10.2307/2095542|issn=0003-1224|jstor=2095542}}</ref><ref>{{cite journal | last1 = Werbach | first1 = M | year = 1992 | title = Nutritional influences on aggressive behavior | journal = J Orthomol Med | volume = 7 | issue = 1| pages = 45–51 }}</ref>


==Background==
==Background==
{{main|Lead poisoning}}
{{main|Lead poisoning}}
[[Lead]] is a naturally occurring [[metal]] of bluish-grey color that has been used for multiple purposes in the history of human [[civilization]].<ref name=":1" /> Being soft and pliable, as well as resistant to [[corrosion]] compared to other metals, has resulted in lead being used for many different items across time. Some of the earliest items made from lead were beads and jewelry dating back to 7th millennium B.C.<ref>{{Cite journal|last=Terekhova|first=N. N.|date=1981|title=The History of Metalworking Production among the Ancient Agriculturalists of Southern Turkmenia|journal=Soviet Anthropology and Archeology|volume=19|issue=3–4|pages=313–324|doi=10.2753/aae1061-1959190304313|issn=0038-528X}}</ref> Its malleability made lead an ideal choice for the Romans to build pipes for transporting water.<ref>{{Cite journal|last=Hodge|first=A. Trevor|date=1981|title=Vitruvius, Lead Pipes and Lead Poisoning|journal=American Journal of Archaeology|volume=85|issue=4|pages=486–491|doi=10.2307/504874|issn=0002-9114|jstor=504874}}</ref><ref>{{Cite journal|last=Boeckx|first=Roger L.|date=1986|title=Lead poisoning in children|journal=Analytical Chemistry|volume=58|issue=2|pages=274A–[288A]|doi=10.1021/ac00293a001|issn=0003-2700|pmc=2060893|pmid=13230485}}</ref><ref>{{Cite journal|last=Delile|first=H.|last2=Blichert-Toft|first2=J.|last3=Goiran|first3=J.-P.|last4=Keay|first4=S.|last5=Albarede|first5=F.|date=2014-04-21|title=Lead in ancient Rome's city waters|journal=Proceedings of the National Academy of Sciences|volume=111|issue=18|pages=6594–6599|doi=10.1073/pnas.1400097111|pmid=24753588|pmc=4020092|issn=0027-8424|bibcode=2014PNAS..111.6594D}}</ref> Furthermore, [[Lead(II) acetate|lead acetate]] (also referred to as "sugar of lead") has been reported to have been used medicinally in the past.<ref>{{Cite book|title=Lead and lead poisoning in antiquity|last=O.|first=Nriagu, Jerome|date=1983|publisher=Wiley|isbn=978-0471087670|oclc=424313729}}</ref> However, it was also noted that exposure to lead may have health consequences. The botanist [[Nicander]] was one of the first to write about the uses of lead.<ref name=":1" /> [[Pedanius Dioscorides|Dioscorides]] would later report that "the mind gives way" in individuals exposed to lead.<ref name=":1" /> Nonetheless, despite the hazards posed by lead, its durability made it useful and it was added to items such as [[Lead glass|glass]], [[Lead paint|paint]],<ref>{{Cite journal|last=Warren|first=Christian|date=1999|title=Toxic Purity: The Progressive Era Origins of America's Lead Paint Poisoning Epidemic|journal=The Business History Review|volume=73|issue=4|pages=705–736|doi=10.2307/3116131|issn=0007-6805|jstor=3116131}}</ref> and eventually [[Leaded gasoline|gasoline]].<ref>{{Cite journal|last=Nriagu|first=Jerome O.|date=1990|title=The rise and fall of leaded gasoline|journal=Science of the Total Environment|volume=92|pages=13–28|doi=10.1016/0048-9697(90)90318-o|issn=0048-9697|bibcode=1990ScTEn..92...13N}}</ref><ref>{{Cite journal|last=Kovarik|first=William|date=2005|title=Ethyl-leaded Gasoline: How a Classic Occupational Disease Became an International Public Health Disaster|journal=International Journal of Occupational and Environmental Health|volume=11|issue=4|pages=384–397|doi=10.1179/oeh.2005.11.4.384|pmid=16350473|issn=1077-3525}}</ref> The widespread substance is also able to function as a shield against various forms of [[radiation]].<ref name="Pediatrics">{{cite journal|last1=Dapul|first1=Dr. Heda|last2=Laraque|first2=Dr. Danielle|date=August 2014|title=Lead Poisoning in Children|url=http://www.advancesinpediatrics.com/article/S0065-3101(14)00016-4/abstract|journal=Advances in Pediatrics|volume=61|issue=1|pages=313–333|access-date=30 November 2016|doi=10.1016/j.yapd.2014.04.004|pmid=25037135}}</ref>
[[Lead]] is a naturally occurring [[metal]] of bluish-grey color that has been used for multiple purposes in the history of human [[civilization]].<ref name=":1" /> Being soft and pliable, as well as resistant to [[corrosion]] compared to other metals, has resulted in lead being used for many different items across time. Some of the earliest items made from lead were beads and jewelry dating back to 7th millennium B.C.<ref>{{Cite journal|last=Terekhova|first=N. N.|date=1981|title=The History of Metalworking Production among the Ancient Agriculturalists of Southern Turkmenia|journal=Soviet Anthropology and Archeology|volume=19|issue=3–4|pages=313–324|doi=10.2753/aae1061-1959190304313|issn=0038-528X}}</ref> Its malleability made lead an ideal choice for the Romans to build pipes for transporting water.<ref>{{Cite journal|last=Hodge|first=A. Trevor|date=1981|title=Vitruvius, Lead Pipes and Lead Poisoning|journal=American Journal of Archaeology|volume=85|issue=4|pages=486–491|doi=10.2307/504874|issn=0002-9114|jstor=504874}}</ref><ref>{{Cite journal|last=Boeckx|first=Roger L.|date=1986|title=Lead poisoning in children|journal=Analytical Chemistry|volume=58|issue=2|pages=274A–[288A]|doi=10.1021/ac00293a001|issn=0003-2700|pmc=2060893|pmid=13230485}}</ref><ref>{{Cite journal|last1=Delile|first1=H.|last2=Blichert-Toft|first2=J.|last3=Goiran|first3=J.-P.|last4=Keay|first4=S.|last5=Albarede|first5=F.|date=2014-04-21|title=Lead in ancient Rome's city waters|journal=Proceedings of the National Academy of Sciences|volume=111|issue=18|pages=6594–6599|doi=10.1073/pnas.1400097111|pmid=24753588|pmc=4020092|issn=0027-8424|bibcode=2014PNAS..111.6594D}}</ref> Furthermore, [[Lead(II) acetate|lead acetate]] (also referred to as "sugar of lead") has been reported to have been used medicinally in the past.<ref>{{Cite book|title=Lead and lead poisoning in antiquity|last=O.|first=Nriagu, Jerome|date=1983|publisher=Wiley|isbn=978-0471087670|oclc=424313729}}</ref> However, it was also noted that exposure to lead may have health consequences. The botanist [[Nicander]] was one of the first to write about the uses of lead.<ref name=":1" /> [[Pedanius Dioscorides|Dioscorides]] would later report that "the mind gives way" in individuals exposed to lead.<ref name=":1" /> Nonetheless, despite the hazards posed by lead, its durability made it useful and it was added to items such as [[Lead glass|glass]], [[Lead paint|paint]],<ref>{{Cite journal|last=Warren|first=Christian|date=1999|title=Toxic Purity: The Progressive Era Origins of America's Lead Paint Poisoning Epidemic|journal=The Business History Review|volume=73|issue=4|pages=705–736|doi=10.2307/3116131|issn=0007-6805|jstor=3116131}}</ref> and eventually [[Leaded gasoline|gasoline]].<ref>{{Cite journal|last=Nriagu|first=Jerome O.|date=1990|title=The rise and fall of leaded gasoline|journal=Science of the Total Environment|volume=92|pages=13–28|doi=10.1016/0048-9697(90)90318-o|issn=0048-9697|bibcode=1990ScTEn..92...13N}}</ref><ref>{{Cite journal|last=Kovarik|first=William|date=2005|title=Ethyl-leaded Gasoline: How a Classic Occupational Disease Became an International Public Health Disaster|journal=International Journal of Occupational and Environmental Health|volume=11|issue=4|pages=384–397|doi=10.1179/oeh.2005.11.4.384|pmid=16350473|s2cid=44633845|issn=1077-3525}}</ref> The widespread substance is also able to function as a shield against various forms of [[radiation]].<ref name="Pediatrics">{{cite journal|last1=Dapul|first1=Dr. Heda|last2=Laraque|first2=Dr. Danielle|date=August 2014|title=Lead Poisoning in Children|url=http://www.advancesinpediatrics.com/article/S0065-3101(14)00016-4/abstract|journal=Advances in Pediatrics|volume=61|issue=1|pages=313–333|access-date=30 November 2016|doi=10.1016/j.yapd.2014.04.004|pmid=25037135}}</ref>


The use of leaded products such as lead paint and leaded gasoline have resulted in higher environmental levels of lead in the air and soil.<ref name=":0" /> Lead is also a stable element and does not break down in the environment, so it must be physically removed. Most cases of lead exposure occur via inhalation or ingestion, though transdermal exposure is also possible.<ref name=":0" /> Once in the body lead has a half-life of approximately 30 days if in the blood, but can remain in the body for 20 to 30 years if it has accumulated in bones and organs.<ref name=":0" /> Expanded scientific investigation into [[organolead chemistry]] and the varied ways in which human biology changes due to lead exposure took place throughout the 20th century. Although it has continued to be in wide use even into the 21st century, greater understanding of [[blood lead levels]] (BLLs) and other factors have meant that a new scientific consensus has emerged. No safe level of lead in the [[Blood|human bloodstream]] exists as such; any amount can contribute to [[Neurology|neurological]] problems and other health issues.<ref name=Pediatrics/>
The use of leaded products such as lead paint and leaded gasoline have resulted in higher environmental levels of lead in the air and soil.<ref name=":0" /> Lead is also a stable element and does not break down in the environment, so it must be physically removed. Most cases of lead exposure occur via inhalation or ingestion, though transdermal exposure is also possible.<ref name=":0" /> Once in the body lead has a half-life of approximately 30 days if in the blood, but can remain in the body for 20 to 30 years if it has accumulated in bones and organs.<ref name=":0" /> Expanded scientific investigation into [[organolead chemistry]] and the varied ways in which human biology changes due to lead exposure took place throughout the 20th century. Although it has continued to be in wide use even into the 21st century, greater understanding of [[blood lead levels]] (BLLs) and other factors have meant that a new scientific consensus has emerged. No safe level of lead in the [[Blood|human bloodstream]] exists as such; any amount can contribute to [[Neurology|neurological]] problems and other health issues.<ref name=Pediatrics/>


Analyses of the role of lead exposure in the [[Human brain|brain]] have been ongoing for the past few decades. Lead can interfere with numerous neurotransmitter systems in the brain, most likely because of its ability to mimic calcium.<ref name=":0" /> Elevation of aminolevulinic acid from lead-induced disruption of heme synthesis results in lead poisoning having symptoms similar to [[Porphyria#Acute_porphyrias|acute porphyria]].<ref>{{cite book |last=Vannotti |first=Alfred | name-list-style = vanc |date=1954 |title=Porphyrins: Their Biological and Chemical Importance |url=https://books.google.com/books?id=-bzoAAAAIAAJ |publisher=Hilger & Watts, Hilger Division |page=126 |quote=Indeed, lead poisoning, like all porphyrin diseases, is accompanied by obstinate constipation, nervous lesions, hyperpigmentation and abdominal attacks. }}</ref><ref>{{cite book|last1=Dancygier|first1=Henryk | name-list-style = vanc |title=Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases|date=2009|publisher=Springer Science & Business Media|isbn=9783642045196|page=1088|url=https://books.google.com/books?id=lrPX8C4p90QC&pg=PA1088|url-status=live|archive-url=https://web.archive.org/web/20170908185104/https://books.google.com/books?id=lrPX8C4p90QC&pg=PA1088|archive-date=8 September 2017|df=dmy-all}}</ref><ref>{{cite journal | vauthors = Akshatha LN, Rukmini MS, Mamatha TS, Sadashiva Rao P, Prashanth B | title = Lead poisoning mimicking acute porphyria! | journal = Journal of Clinical and Diagnostic Research | volume = 8 | issue = 12 | pages = CD01-2 | date = December 2014 | pmid = 25653942 | pmc = 4316248 | doi = 10.7860/JCDR/2014/10597.5315 }}</ref><ref>{{cite journal | vauthors = Tsai MT, Huang SY, Cheng SY | title = Lead Poisoning Can Be Easily Misdiagnosed as Acute Porphyria and Nonspecific Abdominal Pain | journal = Case Reports in Emergency Medicine | volume = 2017 | pages = 9050713 | date = 2017 | pmid = 28630774 | pmc = 5467293 | doi = 10.1155/2017/9050713 }}</ref><ref>{{cite journal | title = Hereditary Coproporphyria | journal = GeneReviews | date = 2018 | pmid = 23236641 | url = https://www.ncbi.nlm.nih.gov/books/NBK114807/ | access-date = 28 February 2020 | quote = the symptoms in lead poisoning closely mimic those of acute porphyria | last1 = Wang | first1 = B. | last2 = Bissell | first2 = D. M. | last3 = Adam | first3 = M. P. | last4 = Ardinger | first4 = H. H. | last5 = Pagon | first5 = R. A. | last6 = Wallace | first6 = S. E. | author7 = Bean LJH | last8 = Stephens | first8 = K. | last9 = Amemiya | first9 = A. }}</ref> Exposure to lead can also alter brain structure and function.<ref name=":2" /><ref name=":3" /><ref>{{Cite journal|last=Brubaker|first=Christopher J.|last2=Schmithorst|first2=Vincent J.|last3=Haynes|first3=Erin N.|last4=Dietrich|first4=Kim N.|last5=Egelhoff|first5=John C.|last6=Lindquist|first6=Diana M.|last7=Lanphear|first7=Bruce P.|last8=Cecil|first8=Kim M.|date=2009|title=Altered myelination and axonal integrity in adults with childhood lead exposure: A diffusion tensor imaging study|journal=NeuroToxicology|volume=30|issue=6|pages=867–875|doi=10.1016/j.neuro.2009.07.007|pmid=19619581|pmc=2789851|issn=0161-813X}}</ref><ref>{{cite journal | last1 = Yuan | first1 = W. | last2 = Holland | first2 = S. K. | last3 = Cecil | first3 = K. M. | last4 = Dietrich | first4 = K. N. | last5 = Wessel | first5 = S. D. | last6 = Altaye | first6 = M. | last7 = Lanphear | first7 = B. P. | year = 2006 | title = The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function | url = https://semanticscholar.org/paper/aa9762d0b44a12612e76b806f91fe47b1c0aeb9b| journal = Pediatrics | volume = 118 | issue = 3| pages = 971–977 | doi=10.1542/peds.2006-0467| pmid = 16950987 }}</ref> At the behavioral level, exposure to lead has been observed to cause increases in impulsive<ref name=":7">{{Cite journal|last=Byers|first=R. K.|last2=Lord|first2=E. E.|date=1944|journal=The Journal of Nervous and Mental Disease|volume=100|issue=4|pages=420|doi=10.1097/00005053-194410000-00009|issn=0022-3018|title=Late Effects of Lead Poisoning on Mental Development}}</ref><ref>Mendelsohn, A. L., Dreyer, B. P., Fierman, A. H., Rosen, C. M., Legano, L. A., Kruger, H. A., ... & Courtlandt, C. D. (1998). Low-level lead exposure and behavior in early childhood. ''Pediatrics'', ''101''(3), e10-e10.</ref> actions and social aggression,<ref>{{cite journal | last1 = Needleman | first1 = H. L. | last2 = McFarland | first2 = C. | last3 = Ness | first3 = R. B. | last4 = Fienberg | first4 = S. E. | last5 = Tobin | first5 = M. J. | year = 2002 | title = Bone lead levels in adjudicated delinquents: a case control study | journal = Neurotoxicology and Teratology | volume = 24 | issue = 6| pages = 711–717 | doi=10.1016/s0892-0362(02)00269-6| pmid = 12460653 }}</ref> as well as the possibility of developing [[attention deficit hyperactivity disorder]] (ADHD).<ref>{{cite journal | last1 = Goodlad | first1 = J. K. | last2 = Marcus | first2 = D. K. | last3 = Fulton | first3 = J. J. | year = 2013 | title = Lead and attention-deficit/hyperactivity disorder (ADHD) symptoms: A meta-analysis | journal = Clinical Psychology Review | volume = 33 | issue = 3| pages = 417–425 | doi=10.1016/j.cpr.2013.01.009| pmid = 23419800 }}</ref> Those conditions likely influence [[personality]] traits and behavioral choices, with examples including having poor [[job performance]],<ref>{{cite journal | last1 = Schwartz | first1 = B. S. | last2 = Stewart | first2 = W. F. | last3 = Bolla | first3 = K. I. | last4 = Simon | first4 = D. | last5 = Bandeen-Roche | first5 = K. | last6 = Gordon | first6 = B. | last7 = Todd | first7 = A. C. | year = 2000 | title = Past adult lead exposure is associated with longitudinal decline in cognitive function | url = https://semanticscholar.org/paper/9cd7eeabfd10f1cfd30db38996d17bb3cd132c60| journal = Neurology | volume = 55 | issue = 8| pages = 1144–1150 | doi=10.1212/wnl.55.8.1144| pmid = 11071492 }}</ref> beginning a pattern of [[substance abuse]],<ref>{{Cite journal|last=Nation|first=Jack R.|last2=Baker|first2=Dorothy M.|last3=Taylor|first3=Betty|last4=Clark|first4=Donald E.|date=1986|title=Dietary lead increases ethanol consumption in the rat.|journal=Behavioral Neuroscience|volume=100|issue=4|pages=525–530|doi=10.1037/0735-7044.100.4.525|issn=1939-0084}}</ref> and undergoing [[teenage pregnancy]].<ref>{{Cite journal|last=Nevin|first=Rick|date=2000|title=How Lead Exposure Relates to Temporal Changes in IQ, Violent Crime, and Unwed Pregnancy|journal=Environmental Research|volume=83|issue=1|pages=1–22|doi=10.1006/enrs.1999.4045|pmid=10845777|issn=0013-9351|bibcode=2000ER.....83....1N|url=https://mpra.ub.uni-muenchen.de/35324/1/MPRA_paper_35324.pdf}}</ref><ref>{{Cite journal|last=Lane|first=Sandra D.|last2=Webster|first2=Noah J.|last3=Levandowski|first3=Brooke A.|last4=Rubinstein|first4=Robert A.|last5=Keefe|first5=Robert H.|last6=Wojtowycz|first6=Martha A.|last7=Cibula|first7=Donald A.|last8=Kingson|first8=Johanna E.F.|last9=Aubry|first9=Richard H.|date=2008|title=Environmental Injustice: Childhood Lead Poisoning, Teen Pregnancy, and Tobacco|journal=Journal of Adolescent Health|volume=42|issue=1|pages=43–49|doi=10.1016/j.jadohealth.2007.06.017|pmid=18155029|issn=1054-139X}}</ref> Evidence that lead exposure contributes to lower [[intelligence quotient]] (IQ) scores goes back to a seminal 1979 study in ''[[Nature (journal)|Nature]]'', with later analysis finding the link particularly robust.<ref name=Pediatrics/><ref name=Reyes/>
Analyses of the role of lead exposure in the [[Human brain|brain]] have been ongoing for the past few decades. Lead can interfere with numerous neurotransmitter systems in the brain, most likely because of its ability to mimic calcium.<ref name=":0" /> Elevation of aminolevulinic acid from lead-induced disruption of heme synthesis results in lead poisoning having symptoms similar to [[Porphyria#Acute_porphyrias|acute porphyria]].<ref>{{cite book |last=Vannotti |first=Alfred | name-list-style = vanc |date=1954 |title=Porphyrins: Their Biological and Chemical Importance |url=https://books.google.com/books?id=-bzoAAAAIAAJ |publisher=Hilger & Watts, Hilger Division |page=126 |quote=Indeed, lead poisoning, like all porphyrin diseases, is accompanied by obstinate constipation, nervous lesions, hyperpigmentation and abdominal attacks. }}</ref><ref>{{cite book|last1=Dancygier|first1=Henryk | name-list-style = vanc |title=Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases|date=2009|publisher=Springer Science & Business Media|isbn=9783642045196|page=1088|url=https://books.google.com/books?id=lrPX8C4p90QC&pg=PA1088|url-status=live|archive-url=https://web.archive.org/web/20170908185104/https://books.google.com/books?id=lrPX8C4p90QC&pg=PA1088|archive-date=8 September 2017|df=dmy-all}}</ref><ref>{{cite journal | vauthors = Akshatha LN, Rukmini MS, Mamatha TS, Sadashiva Rao P, Prashanth B | title = Lead poisoning mimicking acute porphyria! | journal = Journal of Clinical and Diagnostic Research | volume = 8 | issue = 12 | pages = CD01-2 | date = December 2014 | pmid = 25653942 | pmc = 4316248 | doi = 10.7860/JCDR/2014/10597.5315 }}</ref><ref>{{cite journal | vauthors = Tsai MT, Huang SY, Cheng SY | title = Lead Poisoning Can Be Easily Misdiagnosed as Acute Porphyria and Nonspecific Abdominal Pain | journal = Case Reports in Emergency Medicine | volume = 2017 | pages = 9050713 | date = 2017 | pmid = 28630774 | pmc = 5467293 | doi = 10.1155/2017/9050713 }}</ref><ref>{{cite journal | title = Hereditary Coproporphyria | journal = GeneReviews | date = 2018 | pmid = 23236641 | url = https://www.ncbi.nlm.nih.gov/books/NBK114807/ | access-date = 28 February 2020 | quote = the symptoms in lead poisoning closely mimic those of acute porphyria | last1 = Wang | first1 = B. | last2 = Bissell | first2 = D. M. | last3 = Adam | first3 = M. P. | last4 = Ardinger | first4 = H. H. | last5 = Pagon | first5 = R. A. | last6 = Wallace | first6 = S. E. | author7 = Bean LJH | last8 = Stephens | first8 = K. | last9 = Amemiya | first9 = A. }}</ref> Exposure to lead can also alter brain structure and function.<ref name=":2" /><ref name=":3" /><ref>{{Cite journal|last1=Brubaker|first1=Christopher J.|last2=Schmithorst|first2=Vincent J.|last3=Haynes|first3=Erin N.|last4=Dietrich|first4=Kim N.|last5=Egelhoff|first5=John C.|last6=Lindquist|first6=Diana M.|last7=Lanphear|first7=Bruce P.|last8=Cecil|first8=Kim M.|date=2009|title=Altered myelination and axonal integrity in adults with childhood lead exposure: A diffusion tensor imaging study|journal=NeuroToxicology|volume=30|issue=6|pages=867–875|doi=10.1016/j.neuro.2009.07.007|pmid=19619581|pmc=2789851|issn=0161-813X}}</ref><ref>{{cite journal | last1 = Yuan | first1 = W. | last2 = Holland | first2 = S. K. | last3 = Cecil | first3 = K. M. | last4 = Dietrich | first4 = K. N. | last5 = Wessel | first5 = S. D. | last6 = Altaye | first6 = M. | last7 = Lanphear | first7 = B. P. | year = 2006 | title = The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function | url = https://semanticscholar.org/paper/aa9762d0b44a12612e76b806f91fe47b1c0aeb9b| journal = Pediatrics | volume = 118 | issue = 3| pages = 971–977 | doi=10.1542/peds.2006-0467| pmid = 16950987 | s2cid = 9367116 }}</ref> At the behavioral level, exposure to lead has been observed to cause increases in impulsive<ref name=":7">{{Cite journal|last1=Byers|first1=R. K.|last2=Lord|first2=E. E.|date=1944|journal=The Journal of Nervous and Mental Disease|volume=100|issue=4|pages=420|doi=10.1097/00005053-194410000-00009|issn=0022-3018|title=Late Effects of Lead Poisoning on Mental Development}}</ref><ref>Mendelsohn, A. L., Dreyer, B. P., Fierman, A. H., Rosen, C. M., Legano, L. A., Kruger, H. A., ... & Courtlandt, C. D. (1998). Low-level lead exposure and behavior in early childhood. ''Pediatrics'', ''101''(3), e10-e10.</ref> actions and social aggression,<ref>{{cite journal | last1 = Needleman | first1 = H. L. | last2 = McFarland | first2 = C. | last3 = Ness | first3 = R. B. | last4 = Fienberg | first4 = S. E. | last5 = Tobin | first5 = M. J. | year = 2002 | title = Bone lead levels in adjudicated delinquents: a case control study | journal = Neurotoxicology and Teratology | volume = 24 | issue = 6| pages = 711–717 | doi=10.1016/s0892-0362(02)00269-6| pmid = 12460653 }}</ref> as well as the possibility of developing [[attention deficit hyperactivity disorder]] (ADHD).<ref>{{cite journal | last1 = Goodlad | first1 = J. K. | last2 = Marcus | first2 = D. K. | last3 = Fulton | first3 = J. J. | year = 2013 | title = Lead and attention-deficit/hyperactivity disorder (ADHD) symptoms: A meta-analysis | journal = Clinical Psychology Review | volume = 33 | issue = 3| pages = 417–425 | doi=10.1016/j.cpr.2013.01.009| pmid = 23419800 }}</ref> Those conditions likely influence [[personality]] traits and behavioral choices, with examples including having poor [[job performance]],<ref>{{cite journal | last1 = Schwartz | first1 = B. S. | last2 = Stewart | first2 = W. F. | last3 = Bolla | first3 = K. I. | last4 = Simon | first4 = D. | last5 = Bandeen-Roche | first5 = K. | last6 = Gordon | first6 = B. | last7 = Todd | first7 = A. C. | year = 2000 | title = Past adult lead exposure is associated with longitudinal decline in cognitive function | url = https://semanticscholar.org/paper/9cd7eeabfd10f1cfd30db38996d17bb3cd132c60| journal = Neurology | volume = 55 | issue = 8| pages = 1144–1150 | doi=10.1212/wnl.55.8.1144| pmid = 11071492 | s2cid = 17461186 }}</ref> beginning a pattern of [[substance abuse]],<ref>{{Cite journal|last1=Nation|first1=Jack R.|last2=Baker|first2=Dorothy M.|last3=Taylor|first3=Betty|last4=Clark|first4=Donald E.|date=1986|title=Dietary lead increases ethanol consumption in the rat.|journal=Behavioral Neuroscience|volume=100|issue=4|pages=525–530|doi=10.1037/0735-7044.100.4.525|pmid=3741603|issn=1939-0084}}</ref> and undergoing [[teenage pregnancy]].<ref>{{Cite journal|last=Nevin|first=Rick|date=2000|title=How Lead Exposure Relates to Temporal Changes in IQ, Violent Crime, and Unwed Pregnancy|journal=Environmental Research|volume=83|issue=1|pages=1–22|doi=10.1006/enrs.1999.4045|pmid=10845777|issn=0013-9351|bibcode=2000ER.....83....1N|url=https://mpra.ub.uni-muenchen.de/35324/1/MPRA_paper_35324.pdf}}</ref><ref>{{Cite journal|last1=Lane|first1=Sandra D.|last2=Webster|first2=Noah J.|last3=Levandowski|first3=Brooke A.|last4=Rubinstein|first4=Robert A.|last5=Keefe|first5=Robert H.|last6=Wojtowycz|first6=Martha A.|last7=Cibula|first7=Donald A.|last8=Kingson|first8=Johanna E.F.|last9=Aubry|first9=Richard H.|date=2008|title=Environmental Injustice: Childhood Lead Poisoning, Teen Pregnancy, and Tobacco|journal=Journal of Adolescent Health|volume=42|issue=1|pages=43–49|doi=10.1016/j.jadohealth.2007.06.017|pmid=18155029|issn=1054-139X}}</ref> Evidence that lead exposure contributes to lower [[intelligence quotient]] (IQ) scores goes back to a seminal 1979 study in ''[[Nature (journal)|Nature]]'', with later analysis finding the link particularly robust.<ref name=Pediatrics/><ref name=Reyes/>


The heavy metal lead can be found readily in the environment, especially in urban and industrialized areas.<ref name=":0">{{Cite book|title=Toxicological profile for lead.|last=Registry.|first=United States. Agency for Toxic Substances and Disease|date=2007|publisher=U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry|oclc=819638920}}</ref> The majority of modern day environmental lead contamination can be traced back to leaded paint and the addition of [[tetraethyllead]] and [[tetramethyllead]] to gasoline, though other sources have contributed as well.<ref name=":0" /> Though some of the hazards of lead exposure have been documented for centuries,<ref name=":1">{{Cite book|title=Some landmarks in the history of lead poisoning.|last=R.|first=Major, Ralph|date=1931|oclc=230983773}}</ref> recognition of the hazards posed did not appear to gain much traction until the 1960s with the Senate hearings of [[Edmund Muskie]]<ref>Committee on Public Works, Hearings before a Subcommittee on Air and Water Pollution, United States Senate, 89th Congress, Second Section on S-3112 and S-3400, Washington, DC, 1966.</ref> that would help lead to the phaseout of leaded gasoline and lead-based paint in the 1970s.<ref>{{Cite journal|last=Bellinger|first=D. C.|date=2006-03-23|title=Childhood lead poisoning: the torturous path from science to policy|journal=Journal of Clinical Investigation|volume=116|issue=4|pages=853–857|doi=10.1172/jci28232|pmid=16585952|pmc=1421365|issn=0021-9738}}</ref> Blood lead levels would drop notably soon after the phaseout.<ref>{{Cite journal|last=Annest|first=Joseph L.|last2=Pirkle|first2=James L.|last3=Makuc|first3=Diane|last4=Neese|first4=Jane W.|last5=Bayse|first5=David D.|last6=Kovar|first6=Mary Grace|date=1983-06-09|title=Chronological Trend in Blood Lead Levels between 1976 and 1980|journal=New England Journal of Medicine|volume=308|issue=23|pages=1373–1377|doi=10.1056/nejm198306093082301|pmid=6188954|issn=0028-4793}}</ref> In the decades since, scientists have concluded that no safe threshold for lead exposure exists.<ref>{{Cite web|url=https://www.cdc.gov/nceh/lead/default.htm|title=CDC - Lead - Home Page|last=Health|first=National Center for Environmental|date=2018-10-11|website=www.cdc.gov|language=en-us|access-date=2018-10-12}}</ref>
The heavy metal lead can be found readily in the environment, especially in urban and industrialized areas.<ref name=":0">{{Cite book|title=Toxicological profile for lead.|last=Registry.|first=United States. Agency for Toxic Substances and Disease|date=2007|publisher=U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry|oclc=819638920}}</ref> The majority of modern day environmental lead contamination can be traced back to leaded paint and the addition of [[tetraethyllead]] and [[tetramethyllead]] to gasoline, though other sources have contributed as well.<ref name=":0" /> Though some of the hazards of lead exposure have been documented for centuries,<ref name=":1">{{Cite book|title=Some landmarks in the history of lead poisoning.|last=R.|first=Major, Ralph|date=1931|oclc=230983773}}</ref> recognition of the hazards posed did not appear to gain much traction until the 1960s with the Senate hearings of [[Edmund Muskie]]<ref>Committee on Public Works, Hearings before a Subcommittee on Air and Water Pollution, United States Senate, 89th Congress, Second Section on S-3112 and S-3400, Washington, DC, 1966.</ref> that would help lead to the phaseout of leaded gasoline and lead-based paint in the 1970s.<ref>{{Cite journal|last=Bellinger|first=D. C.|date=2006-03-23|title=Childhood lead poisoning: the torturous path from science to policy|journal=Journal of Clinical Investigation|volume=116|issue=4|pages=853–857|doi=10.1172/jci28232|pmid=16585952|pmc=1421365|issn=0021-9738}}</ref> Blood lead levels would drop notably soon after the phaseout.<ref>{{Cite journal|last1=Annest|first1=Joseph L.|last2=Pirkle|first2=James L.|last3=Makuc|first3=Diane|last4=Neese|first4=Jane W.|last5=Bayse|first5=David D.|last6=Kovar|first6=Mary Grace|date=1983-06-09|title=Chronological Trend in Blood Lead Levels between 1976 and 1980|journal=New England Journal of Medicine|volume=308|issue=23|pages=1373–1377|doi=10.1056/nejm198306093082301|pmid=6188954|issn=0028-4793}}</ref> In the decades since, scientists have concluded that no safe threshold for lead exposure exists.<ref>{{Cite web|url=https://www.cdc.gov/nceh/lead/default.htm|title=CDC - Lead - Home Page|last=Health|first=National Center for Environmental|date=2018-10-11|website=www.cdc.gov|language=en-us|access-date=2018-10-12}}</ref>


Though efforts to reduce environmental levels of lead were initially slowed down by the lead industry, the emergence of [[Clair Cameron Patterson|Clair Patterson]] in the 1960s would lead to more meaningful changes.<ref>{{Cite journal|last=Patterson|first=Clair|last2=Ericson|first2=Jonathon|last3=Manea-Krichten|first3=Mirela|last4=Shirahata|first4=Hiroshi|date=1991|title=Natural skeletal levels of lead in Homo sapiens sapiens uncontaminated by technological lead|journal=Science of the Total Environment|volume=107|pages=205–236|doi=10.1016/0048-9697(91)90260-l|pmid=1785050|issn=0048-9697|bibcode=1991ScTEn.107..205P}}</ref><ref>{{cite journal | last1 = Patterson | first1 = C. C. | year = 1965 | title = Contaminated and natural lead environments of man | journal = Archives of Environmental Health | volume = 11 | issue = 3| pages = 344–360 | doi=10.1080/00039896.1965.10664229| pmid = 14334042 }}</ref> The establishment of the [[United States Environmental Protection Agency]] in 1970 and the influence of the [[U.S. Consumer Product Safety Commission|Consumer Product Safety Commission]] would help ensure that gasoline and paint could only contain trace amounts of lead.<ref>{{cite journal | last1 = Lewis | first1 = J | year = 1985 | title = Lead poisoning: a historical perspective | url =https://archive.epa.gov/epa/aboutepa/lead-poisoning-historical-perspective.html | journal = EPA Journal | volume = 11 | page = 15 }}</ref> Furthermore, several major legislative acts were passed to help reduce the amount of lead being introduced into the environment, including the [[Clean Air Act (United States)|Clean Air Act]] of 1970 and the Lead Based Paint Poisoning Prevention Act.<ref>{{Cite web|url=https://www.hud.gov/sites/documents/20258_LEGISLATIVEHISTORY.PDF|title=LEGISLATIVE HISTORY OF LEAD-BASED PAINT|website=U.S. Department of Housing and Urban Development|access-date=November 30, 2018}}</ref>
Though efforts to reduce environmental levels of lead were initially slowed down by the lead industry, the emergence of [[Clair Cameron Patterson|Clair Patterson]] in the 1960s would lead to more meaningful changes.<ref>{{Cite journal|last1=Patterson|first1=Clair|last2=Ericson|first2=Jonathon|last3=Manea-Krichten|first3=Mirela|last4=Shirahata|first4=Hiroshi|date=1991|title=Natural skeletal levels of lead in Homo sapiens sapiens uncontaminated by technological lead|journal=Science of the Total Environment|volume=107|pages=205–236|doi=10.1016/0048-9697(91)90260-l|pmid=1785050|issn=0048-9697|bibcode=1991ScTEn.107..205P}}</ref><ref>{{cite journal | last1 = Patterson | first1 = C. C. | year = 1965 | title = Contaminated and natural lead environments of man | journal = Archives of Environmental Health | volume = 11 | issue = 3| pages = 344–360 | doi=10.1080/00039896.1965.10664229| pmid = 14334042 }}</ref> The establishment of the [[United States Environmental Protection Agency]] in 1970 and the influence of the [[U.S. Consumer Product Safety Commission|Consumer Product Safety Commission]] would help ensure that gasoline and paint could only contain trace amounts of lead.<ref>{{cite journal | last1 = Lewis | first1 = J | year = 1985 | title = Lead poisoning: a historical perspective | url =https://archive.epa.gov/epa/aboutepa/lead-poisoning-historical-perspective.html | journal = EPA Journal | volume = 11 | page = 15 }}</ref> Furthermore, several major legislative acts were passed to help reduce the amount of lead being introduced into the environment, including the [[Clean Air Act (United States)|Clean Air Act]] of 1970 and the Lead Based Paint Poisoning Prevention Act.<ref>{{Cite web|url=https://www.hud.gov/sites/documents/20258_LEGISLATIVEHISTORY.PDF|title=LEGISLATIVE HISTORY OF LEAD-BASED PAINT|website=U.S. Department of Housing and Urban Development|access-date=November 30, 2018}}</ref>


The international process of trying to lower the prevalence of lead has been largely spearheaded by the Partnership for Clean Fuels and Vehicles (PCFV). The [[non-governmental organization]] partners with major [[List of oil exploration and production companies|oil companies]], various governmental departments, multiple [[civil society]] groups, and other such institutions worldwide. Efforts to phase-out lead in transport fuel achieved major gains in over seventy-five nations. In discussions at the [[Earth Summit 2002|2002 Earth Summit]], institutions under the umbrella of the [[United Nations]] vowed to emphasize [[public–private partnerships]] (PPPs) in order to help [[Developing country|developing and transitional countries]] go unleaded.{{refn|name=Phase-out}}
The international process of trying to lower the prevalence of lead has been largely spearheaded by the Partnership for Clean Fuels and Vehicles (PCFV). The [[non-governmental organization]] partners with major [[List of oil exploration and production companies|oil companies]], various governmental departments, multiple [[civil society]] groups, and other such institutions worldwide. Efforts to phase-out lead in transport fuel achieved major gains in over seventy-five nations. In discussions at the [[Earth Summit 2002|2002 Earth Summit]], institutions under the umbrella of the [[United Nations]] vowed to emphasize [[public–private partnerships]] (PPPs) in order to help [[Developing country|developing and transitional countries]] go unleaded.{{refn|name=Phase-out}}
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==Research on lead–crime correlation==
==Research on lead–crime correlation==


The lead-crime hypothesis arose out of the confluence of several events, primarily the decrease in crime rates in the 1990s and the reduction of environmental lead pollution in the 1970s.<ref>{{Cite journal|last=Carpenter|first=David O.|last2=Nevin|first2=Rick|date=2010|title=Environmental causes of violence|journal=Physiology & Behavior|volume=99|issue=2|pages=260–268|doi=10.1016/j.physbeh.2009.09.001|pmid=19758571|issn=0031-9384}}</ref> After decades of relatively steady increases, [[crime rates in the United States]] started to sharply decline in the 1990s. The trend continued into the new millennium. Multiple possible explanations have come about, with academic studies pointing to [[Causality#Statistics and economics|complex, multifactorial causation]] as different social trends occurred at the same time.<ref name=Reyes/> The fact that in the [[United States]] anti-lead efforts took place simultaneously alongside falls in violent crime rates attracted attention from researchers. Changes were not uniform across the country, even while increasingly stringent [[U.S. Environmental Protection Agency|Environmental Protection Agency]] rules went into force from 1970s onward. Several areas had far greater lead exposure compared to others for years.<ref name=Reyes/>
The lead-crime hypothesis arose out of the confluence of several events, primarily the decrease in crime rates in the 1990s and the reduction of environmental lead pollution in the 1970s.<ref>{{Cite journal|last1=Carpenter|first1=David O.|last2=Nevin|first2=Rick|date=2010|title=Environmental causes of violence|journal=Physiology & Behavior|volume=99|issue=2|pages=260–268|doi=10.1016/j.physbeh.2009.09.001|pmid=19758571|s2cid=5706643|issn=0031-9384}}</ref> After decades of relatively steady increases, [[crime rates in the United States]] started to sharply decline in the 1990s. The trend continued into the new millennium. Multiple possible explanations have come about, with academic studies pointing to [[Causality#Statistics and economics|complex, multifactorial causation]] as different social trends occurred at the same time.<ref name=Reyes/> The fact that in the [[United States]] anti-lead efforts took place simultaneously alongside falls in violent crime rates attracted attention from researchers. Changes were not uniform across the country, even while increasingly stringent [[U.S. Environmental Protection Agency|Environmental Protection Agency]] rules went into force from 1970s onward. Several areas had far greater lead exposure compared to others for years.<ref name=Reyes/>


While there is strong evidence indicating that genetics influence the development of violent and aggressive behavior,<ref>{{cite journal | last1 = Baker | first1 = L. A. | last2 = Jacobson | first2 = K. C. | last3 = Raine | first3 = A. | last4 = Lozano | first4 = D. I. | last5 = Bezdjian | first5 = S. | year = 2007 | title = Genetic and environmental bases of childhood antisocial behavior: a multi-informant twin study | journal = Journal of Abnormal Psychology | volume = 116 | issue = 2| pages = 219–35 | doi=10.1037/0021-843x.116.2.219| pmid = 17516756 | pmc = 1913189 }}</ref><ref>{{cite journal | last1 = Baker | first1 = L. A. | last2 = Raine | first2 = A. | last3 = Liu | first3 = J. | last4 = Jacobson | first4 = K. C. | year = 2008 | title = Differential genetic and environmental influences on reactive and proactive aggression in children | journal = Journal of Abnormal Child Psychology | volume = 36 | issue = 8| pages = 1265–1278 | doi=10.1007/s10802-008-9249-1| pmid = 18615267 | pmc = 2609906 }}</ref> more recent attention has focused on environmental factors such as lead exposure.<ref>Raine, A. (2014). ''The anatomy of violence: The biological roots of crime''. New York: NY, Vintage.</ref> Though there is anecdotal evidence suggesting that knowledge of a relationship between lead exposure and behavior dates back centuries,<ref name=":1" /> direct observations would not be documented until the late 1800s.<ref>Gibson, J. L., Love, W., Hardie, D., Bancroft, P., & Turner, A. J. (1892). Notes on lead-poisoning as observed among children in Brisbane. In ''Proceedings of the Third Intercolonial Medical Congress, Sydney, Australia'' (pp. 76-83).</ref> Research in the mid-1900s observed that children previously treated for lead poisoning displayed a series of aberrant behaviors, including violence and aggression.<ref name=":7" /><ref>{{cite journal |last1=Bryce-Smith |first1=D |last2=Waldron |first2=H.A. |date=December 1974 |title=Does Lead Create Criminals? |url=https://www.resurgence.org/grafix/ecologist/covers/600/1974-12.jpg |journal=The Ecologist |volume=4 |issue=10 |pages=355-377 |access-date=March 11, 2021 |via=https://www.resurgence.org/magazine/ecologist/issues1970-1979.html}}</ref> Further research has yielded similar results, finding that past lead exposure functions as a predictor for criminal activity.<ref name=":6" /><ref>{{Cite journal|last=PIHL|first=R. O.|date=1990|title=LEAD AND CADMIUM LEVELS IN VIOLENT CRIMINALS|journal=Psychological Reports|volume=66|issue=3|pages=839|doi=10.2466/pr0.66.3.839-844|issn=0033-2941}}</ref><ref>{{Cite book|title=Biology and Violence : From Birth to Adulthood|last=W.|first=Denno, Deborah|date=2010|publisher=Cambridge University Press|isbn=9780511752803|oclc=900190649|url-access=registration|url=https://archive.org/details/biologyviolencef0000denn}}</ref><ref>{{Cite journal|last=Needleman|first=Herbert L.|date=1996|title=Bone Lead Levels and Delinquent Behavior|journal=JAMA: The Journal of the American Medical Association|volume=275|issue=5|pages=363–369|doi=10.1001/jama.1996.03530460029026|issn=0098-7484}}</ref> Nation-wide analyses have also demonstrated positive associations between air-lead concentrations and measures of criminality and homicide.<ref name=":4" /><ref>{{Cite journal|last=Stretesky|first=Paul B.|last2=Lynch|first2=Michael J.|date=2001-05-01|title=The Relationship Between Lead Exposure and Homicide|journal=Archives of Pediatrics & Adolescent Medicine|volume=155|issue=5|pages=579|doi=10.1001/archpedi.155.5.579|pmid=11343501|issn=1072-4710|doi-access=free}}</ref> A meta-analysis of studies examining the relationship between lead and conduct problems arrived at a similar conclusion, suggesting that the magnitude of the relationship between lead exposure and behavior is comparable to the relationship between lead exposure and I.Q.<ref name=":5" /> While the scientific literature suggests there is a relationship between lead exposure and behavioral issues such as delinquency and criminality, directly relating these observations to the decrease in overall criminality is more difficult.
While there is strong evidence indicating that genetics influence the development of violent and aggressive behavior,<ref>{{cite journal | last1 = Baker | first1 = L. A. | last2 = Jacobson | first2 = K. C. | last3 = Raine | first3 = A. | last4 = Lozano | first4 = D. I. | last5 = Bezdjian | first5 = S. | year = 2007 | title = Genetic and environmental bases of childhood antisocial behavior: a multi-informant twin study | journal = Journal of Abnormal Psychology | volume = 116 | issue = 2| pages = 219–35 | doi=10.1037/0021-843x.116.2.219| pmid = 17516756 | pmc = 1913189 }}</ref><ref>{{cite journal | last1 = Baker | first1 = L. A. | last2 = Raine | first2 = A. | last3 = Liu | first3 = J. | last4 = Jacobson | first4 = K. C. | year = 2008 | title = Differential genetic and environmental influences on reactive and proactive aggression in children | journal = Journal of Abnormal Child Psychology | volume = 36 | issue = 8| pages = 1265–1278 | doi=10.1007/s10802-008-9249-1| pmid = 18615267 | pmc = 2609906 }}</ref> more recent attention has focused on environmental factors such as lead exposure.<ref>Raine, A. (2014). ''The anatomy of violence: The biological roots of crime''. New York: NY, Vintage.</ref> Though there is anecdotal evidence suggesting that knowledge of a relationship between lead exposure and behavior dates back centuries,<ref name=":1" /> direct observations would not be documented until the late 1800s.<ref>Gibson, J. L., Love, W., Hardie, D., Bancroft, P., & Turner, A. J. (1892). Notes on lead-poisoning as observed among children in Brisbane. In ''Proceedings of the Third Intercolonial Medical Congress, Sydney, Australia'' (pp. 76-83).</ref> Research in the mid-1900s observed that children previously treated for lead poisoning displayed a series of aberrant behaviors, including violence and aggression.<ref name=":7" /><ref>{{cite journal |last1=Bryce-Smith |first1=D |last2=Waldron |first2=H.A. |date=December 1974 |title=Does Lead Create Criminals? |url=https://www.resurgence.org/grafix/ecologist/covers/600/1974-12.jpg |journal=The Ecologist |volume=4 |issue=10 |pages=355–377 |access-date=March 11, 2021 |via=https://www.resurgence.org/magazine/ecologist/issues1970-1979.html}}</ref> Further research has yielded similar results, finding that past lead exposure functions as a predictor for criminal activity.<ref name=":6" /><ref>{{Cite journal|last=PIHL|first=R. O.|date=1990|title=LEAD AND CADMIUM LEVELS IN VIOLENT CRIMINALS|journal=Psychological Reports|volume=66|issue=3|pages=839–844|doi=10.2466/pr0.66.3.839-844|pmid=2377701|issn=0033-2941}}</ref><ref>{{Cite book|title=Biology and Violence : From Birth to Adulthood|last=W.|first=Denno, Deborah|date=2010|publisher=Cambridge University Press|isbn=9780511752803|oclc=900190649|url-access=registration|url=https://archive.org/details/biologyviolencef0000denn}}</ref><ref>{{Cite journal|last=Needleman|first=Herbert L.|date=1996|title=Bone Lead Levels and Delinquent Behavior|journal=JAMA: The Journal of the American Medical Association|volume=275|issue=5|pages=363–369|doi=10.1001/jama.1996.03530460029026|pmid=8569015|issn=0098-7484}}</ref> Nation-wide analyses have also demonstrated positive associations between air-lead concentrations and measures of criminality and homicide.<ref name=":4" /><ref>{{Cite journal|last1=Stretesky|first1=Paul B.|last2=Lynch|first2=Michael J.|date=2001-05-01|title=The Relationship Between Lead Exposure and Homicide|journal=Archives of Pediatrics & Adolescent Medicine|volume=155|issue=5|pages=579–582|doi=10.1001/archpedi.155.5.579|pmid=11343501|issn=1072-4710|doi-access=free}}</ref> A meta-analysis of studies examining the relationship between lead and conduct problems arrived at a similar conclusion, suggesting that the magnitude of the relationship between lead exposure and behavior is comparable to the relationship between lead exposure and I.Q.<ref name=":5" /> While the scientific literature suggests there is a relationship between lead exposure and behavioral issues such as delinquency and criminality, directly relating these observations to the decrease in overall criminality is more difficult.


According to Jessica Wolpaw Reyes of [[Amherst College]], between 1992 and 2002 the [[Tetraethyllead#Phaseout and ban|phase-out of lead from gasoline]] in the U.S. "was responsible for approximately a 56% decline in violent crime". While cautioning that the findings relating to "murder are not robust if New York and the District of Columbia are included," Wolpaw Reyes concluded: "Overall, the phase-out of lead and the legalization of abortion appear to have been responsible for significant reductions in violent crime rates." She additionally speculated that by "2020, all adults in their 20s and 30s will have grown up without any direct exposure to gasoline lead during childhood, and their crime rates could be correspondingly lower."<ref name=Reyes>{{cite journal|last1=Reyes|first1=Jessica Wolpaw|date=2007|url=http://www3.amherst.edu/~jwreyes/papers/LeadCrimeBEJEAP.pdf|title=Environmental Policy as Social Policy? The Impact of Childhood Lead Exposure on Crime|journal=The B.E. Journal of Economic Analysis & Policy|issue=1|volume=7|access-date=30 November 2016|doi=10.2202/1935-1682.1796}}</ref> According to Reyes, "Childhood lead exposure increases the likelihood of behavioral and cognitive traits such as impulsivity, aggressivity, and low IQ that are strongly associated with criminal behavior".<ref name=Reyes/>[[File:Achim_Steiner-IMG 0837.jpg|thumb|right|200px|[[German Brazilians|Brazilian-German]] [[economist]] [[Achim Steiner]], speaking as then head of the [[United Nations Environment Programme|U.N. Environment Programme]], described anti-lead efforts as a key [[sustainable development]] success.{{Citation needed|date=October 2018}}]]
According to Jessica Wolpaw Reyes of [[Amherst College]], between 1992 and 2002 the [[Tetraethyllead#Phaseout and ban|phase-out of lead from gasoline]] in the U.S. "was responsible for approximately a 56% decline in violent crime". While cautioning that the findings relating to "murder are not robust if New York and the District of Columbia are included," Wolpaw Reyes concluded: "Overall, the phase-out of lead and the legalization of abortion appear to have been responsible for significant reductions in violent crime rates." She additionally speculated that by "2020, all adults in their 20s and 30s will have grown up without any direct exposure to gasoline lead during childhood, and their crime rates could be correspondingly lower."<ref name=Reyes>{{cite journal|last1=Reyes|first1=Jessica Wolpaw|date=2007|url=http://www3.amherst.edu/~jwreyes/papers/LeadCrimeBEJEAP.pdf|title=Environmental Policy as Social Policy? The Impact of Childhood Lead Exposure on Crime|journal=The B.E. Journal of Economic Analysis & Policy|issue=1|volume=7|access-date=30 November 2016|doi=10.2202/1935-1682.1796}}</ref> According to Reyes, "Childhood lead exposure increases the likelihood of behavioral and cognitive traits such as impulsivity, aggressivity, and low IQ that are strongly associated with criminal behavior".<ref name=Reyes/>[[File:Achim_Steiner-IMG 0837.jpg|thumb|right|200px|[[German Brazilians|Brazilian-German]] [[economist]] [[Achim Steiner]], speaking as then head of the [[United Nations Environment Programme|U.N. Environment Programme]], described anti-lead efforts as a key [[sustainable development]] success.{{Citation needed|date=October 2018}}]]
Line 36: Line 37:
According to a May 2017 study, lead exposure in childhood substantially increased school suspensions and juvenile detention among boys in [[Rhode Island]], suggesting that the phasing out of leaded gasoline may explain a significant part of the decline in crime in the United States beginning in the 1990s.<ref name="Doleac">{{cite web |last1=Doleac |first1=Jennifer L. |title=New evidence that lead exposure increases crime |url=https://www.brookings.edu/blog/up-front/2017/06/01/new-evidence-that-lead-exposure-increases-crime/ |publisher=The Brookings Institution |date=1 June 2017}}</ref><ref>{{Cite journal |last1=Aizer |first1=Anna |last2=Currie |first2=Janet |date=May 2017 |title=Lead and Juvenile Delinquency: New Evidence from Linked Birth, School and Juvenile Detention Records |doi=10.3386/w23392 |journal=NBER Working Paper No. 23392 |doi-access=free }}</ref>
According to a May 2017 study, lead exposure in childhood substantially increased school suspensions and juvenile detention among boys in [[Rhode Island]], suggesting that the phasing out of leaded gasoline may explain a significant part of the decline in crime in the United States beginning in the 1990s.<ref name="Doleac">{{cite web |last1=Doleac |first1=Jennifer L. |title=New evidence that lead exposure increases crime |url=https://www.brookings.edu/blog/up-front/2017/06/01/new-evidence-that-lead-exposure-increases-crime/ |publisher=The Brookings Institution |date=1 June 2017}}</ref><ref>{{Cite journal |last1=Aizer |first1=Anna |last2=Currie |first2=Janet |date=May 2017 |title=Lead and Juvenile Delinquency: New Evidence from Linked Birth, School and Juvenile Detention Records |doi=10.3386/w23392 |journal=NBER Working Paper No. 23392 |doi-access=free }}</ref>


A 2018 longitudinal study conducted in New Zealand found only a weak association between childhood lead levels and criminal conviction, which was no longer significant after controlling for sex. In New Zealand, there is no correlation between lead exposure and socioeconomic status, thus social class does not act as a confounder. The authors conclude that "past studies of the association between BLL and crime, in which high BLL and low socioeconomic status were associated, may not have completely overcome confounding".<ref>{{Cite journal| doi = 10.1001/jamapediatrics.2017.4005| issn = 2168-6203| volume = 172| issue = 2| pages = 166–173| last1 = Beckley| first1 = Amber L.| last2 = Caspi| first2 = Avshalom| last3 = Broadbent| first3 = Jonathan| last4 = Harrington| first4 = Honalee| last5 = Houts| first5 = Renate M.| last6 = Poulton| first6 = Richie| last7 = Ramrakha| first7 = Sandhya| last8 = Reuben| first8 = Aaron| last9 = Moffitt| first9 = Terrie E.| title = Association of Childhood Blood Lead Levels With Criminal Offending| journal = JAMA Pediatrics| access-date = 2020-08-06| date = 2018-02-01| url = https://jamanetwork.com/journals/jamapediatrics/fullarticle/2666777| doi-access = free}}</ref>{{Primary source inline|date=March 2021}} Data from the same cohort was published the next year as well and has been cited in review papers as evidence of lead poisoning having long-lasting consequences for mental health and personality.<ref name="2019-Reuben-video">{{cite web |url=https://edhub.ama-assn.org/jn-learning/video-player/17844517 |title=Childhood Lead Exposure, Adult Personality, and Later-Life Mental Health |author=<!--Not stated--> |date=3 September 2019 |website=AMA Ed Hub |publisher=JN Learning |access-date=13 December 2020 |quote=This JAMA Medical News video summarizes findings from a recent cohort study reporting an association between childhood lead exposure in Dunedin, New Zealand, and adult personality traits and psychopathology.}}</ref><ref name="2019-Reuben-article">{{cite web |url=https://jamanetwork.com/journals/jama/fullarticle/2729713 |title=Childhood Lead Exposure May Affect Personality, Mental Health in Adulthood |last=Sancar |first=Feyza |date=March 27, 2019 |website=Medical News & Perspectives |publisher=JAMA |access-date=March 13, 2021 |quote=The findings suggest that lead exposure during childhood may have long-lasting consequences for mental health and personality.}}</ref><ref name="2019-Reuben-citation">{{cite journal |last1=Neuwirth |first1=Lorenz S |last2=Lopez |first2=Oscar E. |date=2020 |title=Low-level lead exposure impairs fronto-executive functions: A call to update the DSM–5 with lead poisoning as a neurodevelopmental disorder. |url=https://psycnet.apa.org/record/2020-43447-001 |journal=Psychology & Neuroscience |volume=13 |issue=3 |pages=299-315 |doi=10.1037/pne0000225 |access-date=March 13, 2021}}</ref>
A 2018 longitudinal study conducted in New Zealand found only a weak association between childhood lead levels and criminal conviction, which was no longer significant after controlling for sex. In New Zealand, there is no correlation between lead exposure and socioeconomic status, thus social class does not act as a confounder. The authors conclude that "past studies of the association between BLL and crime, in which high BLL and low socioeconomic status were associated, may not have completely overcome confounding".<ref>{{Cite journal| doi = 10.1001/jamapediatrics.2017.4005| issn = 2168-6203| volume = 172| issue = 2| pages = 166–173| last1 = Beckley| first1 = Amber L.| last2 = Caspi| first2 = Avshalom| last3 = Broadbent| first3 = Jonathan| last4 = Harrington| first4 = Honalee| last5 = Houts| first5 = Renate M.| last6 = Poulton| first6 = Richie| last7 = Ramrakha| first7 = Sandhya| last8 = Reuben| first8 = Aaron| last9 = Moffitt| first9 = Terrie E.| title = Association of Childhood Blood Lead Levels With Criminal Offending| journal = JAMA Pediatrics| date = 2018-02-01| pmid = 29279896| pmc = 5801257| doi-access = free}}</ref>{{Primary source inline|date=March 2021}} Data from the same cohort was published the next year as well and has been cited in review papers as evidence of lead poisoning having long-lasting consequences for mental health and personality.<ref name="2019-Reuben-video">{{cite web |url=https://edhub.ama-assn.org/jn-learning/video-player/17844517 |title=Childhood Lead Exposure, Adult Personality, and Later-Life Mental Health |author=<!--Not stated--> |date=3 September 2019 |website=AMA Ed Hub |publisher=JN Learning |access-date=13 December 2020 |quote=This JAMA Medical News video summarizes findings from a recent cohort study reporting an association between childhood lead exposure in Dunedin, New Zealand, and adult personality traits and psychopathology.}}</ref><ref name="2019-Reuben-article">{{cite journal |url=https://jamanetwork.com/journals/jama/fullarticle/2729713 |title=Childhood Lead Exposure May Affect Personality, Mental Health in Adulthood |last=Sancar |first=Feyza |date=March 27, 2019 |journal=JAMA |volume=321 |issue=15 |pages=1445–1446 |doi=10.1001/jama.2019.1116 |pmid=30916713 |access-date=March 13, 2021 |quote=The findings suggest that lead exposure during childhood may have long-lasting consequences for mental health and personality.}}</ref><ref name="2019-Reuben-citation">{{cite journal |last1=Neuwirth |first1=Lorenz S |last2=Lopez |first2=Oscar E. |date=2020 |title=Low-level lead exposure impairs fronto-executive functions: A call to update the DSM–5 with lead poisoning as a neurodevelopmental disorder. |url=https://psycnet.apa.org/record/2020-43447-001 |journal=Psychology & Neuroscience |volume=13 |issue=3 |pages=299–315 |doi=10.1037/pne0000225 |access-date=March 13, 2021}}</ref>


==See also==
==See also==
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==Further reading==
==Further reading==


* {{cite journal |last1=Carpenter |first1=David O. |last2=Nevin |first2=Rick |title=Environmental causes of violence |journal=Physiology & Behavior |date=February 2010 |volume=99 |issue=2 |pages=260–268 |doi=10.1016/j.physbeh.2009.09.001 |pmid=19758571 |url=https://election.princeton.edu/wp-content/uploads/2013/01/violence_lead_Nevin.pdf}}
* {{cite journal |last1=Carpenter |first1=David O. |last2=Nevin |first2=Rick |title=Environmental causes of violence |journal=Physiology & Behavior |date=February 2010 |volume=99 |issue=2 |pages=260–268 |doi=10.1016/j.physbeh.2009.09.001 |pmid=19758571 |s2cid=5706643 |url=https://election.princeton.edu/wp-content/uploads/2013/01/violence_lead_Nevin.pdf}}
* {{cite news |last=Casciani |first=Dominic |title=Did removing lead from petrol spark a decline in crime? |work=BBC News |url=https://www.bbc.com/news/magazine-27067615 |date=21 April 2014}}
* {{cite news |last=Casciani |first=Dominic |title=Did removing lead from petrol spark a decline in crime? |work=BBC News |url=https://www.bbc.com/news/magazine-27067615 |date=21 April 2014}}
* {{cite magazine |last1=Drum |first1=Kevin |title=Lead: America's Real Criminal Element |url=https://www.motherjones.com/environment/2016/02/lead-exposure-gasoline-crime-increase-children-health |magazine=Mother Jones |date=11 February 2016}}
* {{cite magazine |last1=Drum |first1=Kevin |title=Lead: America's Real Criminal Element |url=https://www.motherjones.com/environment/2016/02/lead-exposure-gasoline-crime-increase-children-health |magazine=Mother Jones |date=11 February 2016}}

Revision as of 21:07, 30 April 2021

An American fuel pump that dispensed gasoline with tetraethyllead additives.

The lead–crime hypothesis is the association between elevated blood lead levels in children and increased rates of crime, delinquency, and recidivism later in life.[1][2][3][4][5][6]

Lead is widely understood to be highly toxic to multiple organs of the body,[7] particularly the brain.[8][9][10] Individuals exposed to lead at young ages are more vulnerable to learning disabilities,[11][12] decreased I.Q.,[13] attention deficit hyperactivity disorder,[14][15] and problems with impulse control,[16] all of which may be negatively impacting decision making and leading to the commission of more crimes as these children reach adulthood, especially violent crimes.[17] No safe level of lead in the human bloodstream exists given that any amount can contribute to deleterious health issues.[18]

Proponents of the lead–crime hypothesis argue that the removal of lead additives from motor fuel, and the consequent decline in children's lead exposure, explains the fall in crime rates in the United States beginning in the 1990s.[19] This hypothesis also offers an explanation of the earlier rise in crime in the preceding decades as the result of increased lead exposure throughout the mid-20th century.[20]

The lead–crime hypothesis is not mutually exclusive with other explanations of the drop in US crime rates[21][22] such as the legalized abortion and crime effect.[23] Lead exposure during the years in question correlated with exposure to urban poverty, due to close residential or primary school proximity with high-density motor vehicle traffic burning leaded gasoline or from residing in older, poorly maintained housing stock, much of which contained high levels of lead in the form of lead paint, lead solder, or other lead-based building materials; additionally, municipalities with a low taxation base often continued to receive drinking water via degraded lead pipes rather than upgrading to modern infrastructure. The difficulty in measuring the effect of lead exposure on crime rates lies in separating the effect from other indicators of low socioeconomic status such as poorer schools, nutrition, and medical care, exposure to other pollutants, and other variables that are predictive of criminal behavior.[24][25][26][27]

Background

Lead is a naturally occurring metal of bluish-grey color that has been used for multiple purposes in the history of human civilization.[28] Being soft and pliable, as well as resistant to corrosion compared to other metals, has resulted in lead being used for many different items across time. Some of the earliest items made from lead were beads and jewelry dating back to 7th millennium B.C.[29] Its malleability made lead an ideal choice for the Romans to build pipes for transporting water.[30][31][32] Furthermore, lead acetate (also referred to as "sugar of lead") has been reported to have been used medicinally in the past.[33] However, it was also noted that exposure to lead may have health consequences. The botanist Nicander was one of the first to write about the uses of lead.[28] Dioscorides would later report that "the mind gives way" in individuals exposed to lead.[28] Nonetheless, despite the hazards posed by lead, its durability made it useful and it was added to items such as glass, paint,[34] and eventually gasoline.[35][36] The widespread substance is also able to function as a shield against various forms of radiation.[18]

The use of leaded products such as lead paint and leaded gasoline have resulted in higher environmental levels of lead in the air and soil.[37] Lead is also a stable element and does not break down in the environment, so it must be physically removed. Most cases of lead exposure occur via inhalation or ingestion, though transdermal exposure is also possible.[37] Once in the body lead has a half-life of approximately 30 days if in the blood, but can remain in the body for 20 to 30 years if it has accumulated in bones and organs.[37] Expanded scientific investigation into organolead chemistry and the varied ways in which human biology changes due to lead exposure took place throughout the 20th century. Although it has continued to be in wide use even into the 21st century, greater understanding of blood lead levels (BLLs) and other factors have meant that a new scientific consensus has emerged. No safe level of lead in the human bloodstream exists as such; any amount can contribute to neurological problems and other health issues.[18]

Analyses of the role of lead exposure in the brain have been ongoing for the past few decades. Lead can interfere with numerous neurotransmitter systems in the brain, most likely because of its ability to mimic calcium.[37] Elevation of aminolevulinic acid from lead-induced disruption of heme synthesis results in lead poisoning having symptoms similar to acute porphyria.[38][39][40][41][42] Exposure to lead can also alter brain structure and function.[8][9][43][44] At the behavioral level, exposure to lead has been observed to cause increases in impulsive[45][46] actions and social aggression,[47] as well as the possibility of developing attention deficit hyperactivity disorder (ADHD).[48] Those conditions likely influence personality traits and behavioral choices, with examples including having poor job performance,[49] beginning a pattern of substance abuse,[50] and undergoing teenage pregnancy.[51][52] Evidence that lead exposure contributes to lower intelligence quotient (IQ) scores goes back to a seminal 1979 study in Nature, with later analysis finding the link particularly robust.[18][53]

The heavy metal lead can be found readily in the environment, especially in urban and industrialized areas.[37] The majority of modern day environmental lead contamination can be traced back to leaded paint and the addition of tetraethyllead and tetramethyllead to gasoline, though other sources have contributed as well.[37] Though some of the hazards of lead exposure have been documented for centuries,[28] recognition of the hazards posed did not appear to gain much traction until the 1960s with the Senate hearings of Edmund Muskie[54] that would help lead to the phaseout of leaded gasoline and lead-based paint in the 1970s.[55] Blood lead levels would drop notably soon after the phaseout.[56] In the decades since, scientists have concluded that no safe threshold for lead exposure exists.[57]

Though efforts to reduce environmental levels of lead were initially slowed down by the lead industry, the emergence of Clair Patterson in the 1960s would lead to more meaningful changes.[58][59] The establishment of the United States Environmental Protection Agency in 1970 and the influence of the Consumer Product Safety Commission would help ensure that gasoline and paint could only contain trace amounts of lead.[60] Furthermore, several major legislative acts were passed to help reduce the amount of lead being introduced into the environment, including the Clean Air Act of 1970 and the Lead Based Paint Poisoning Prevention Act.[61]

The international process of trying to lower the prevalence of lead has been largely spearheaded by the Partnership for Clean Fuels and Vehicles (PCFV). The non-governmental organization partners with major oil companies, various governmental departments, multiple civil society groups, and other such institutions worldwide. Efforts to phase-out lead in transport fuel achieved major gains in over seventy-five nations. In discussions at the 2002 Earth Summit, institutions under the umbrella of the United Nations vowed to emphasize public–private partnerships (PPPs) in order to help developing and transitional countries go unleaded.[62]

Research on lead–crime correlation

The lead-crime hypothesis arose out of the confluence of several events, primarily the decrease in crime rates in the 1990s and the reduction of environmental lead pollution in the 1970s.[63] After decades of relatively steady increases, crime rates in the United States started to sharply decline in the 1990s. The trend continued into the new millennium. Multiple possible explanations have come about, with academic studies pointing to complex, multifactorial causation as different social trends occurred at the same time.[53] The fact that in the United States anti-lead efforts took place simultaneously alongside falls in violent crime rates attracted attention from researchers. Changes were not uniform across the country, even while increasingly stringent Environmental Protection Agency rules went into force from 1970s onward. Several areas had far greater lead exposure compared to others for years.[53]

While there is strong evidence indicating that genetics influence the development of violent and aggressive behavior,[64][65] more recent attention has focused on environmental factors such as lead exposure.[66] Though there is anecdotal evidence suggesting that knowledge of a relationship between lead exposure and behavior dates back centuries,[28] direct observations would not be documented until the late 1800s.[67] Research in the mid-1900s observed that children previously treated for lead poisoning displayed a series of aberrant behaviors, including violence and aggression.[45][68] Further research has yielded similar results, finding that past lead exposure functions as a predictor for criminal activity.[4][69][70][71] Nation-wide analyses have also demonstrated positive associations between air-lead concentrations and measures of criminality and homicide.[1][72] A meta-analysis of studies examining the relationship between lead and conduct problems arrived at a similar conclusion, suggesting that the magnitude of the relationship between lead exposure and behavior is comparable to the relationship between lead exposure and I.Q.[3] While the scientific literature suggests there is a relationship between lead exposure and behavioral issues such as delinquency and criminality, directly relating these observations to the decrease in overall criminality is more difficult.

According to Jessica Wolpaw Reyes of Amherst College, between 1992 and 2002 the phase-out of lead from gasoline in the U.S. "was responsible for approximately a 56% decline in violent crime". While cautioning that the findings relating to "murder are not robust if New York and the District of Columbia are included," Wolpaw Reyes concluded: "Overall, the phase-out of lead and the legalization of abortion appear to have been responsible for significant reductions in violent crime rates." She additionally speculated that by "2020, all adults in their 20s and 30s will have grown up without any direct exposure to gasoline lead during childhood, and their crime rates could be correspondingly lower."[53] According to Reyes, "Childhood lead exposure increases the likelihood of behavioral and cognitive traits such as impulsivity, aggressivity, and low IQ that are strongly associated with criminal behavior".[53]

Brazilian-German economist Achim Steiner, speaking as then head of the U.N. Environment Programme, described anti-lead efforts as a key sustainable development success.[citation needed]

A 2011 study by the California State University found that "Ridding the world of leaded petrol, with the United Nations leading the effort in developing countries, has resulted in $2.4 trillion in annual benefits, 1.2 million fewer premature deaths, higher overall intelligence and 58 million fewer crimes", according to the United Nations News Centre.[62] The executive director of the United Nations Environment Programme (UNEP) Achim Steiner argued that "Although this global effort has often flown below the radar of [the] media and global leaders, it is clear that the elimination of leaded petrol is an immense achievement on par with the global elimination of major deadly diseases."[62]

According to a May 2017 study, lead exposure in childhood substantially increased school suspensions and juvenile detention among boys in Rhode Island, suggesting that the phasing out of leaded gasoline may explain a significant part of the decline in crime in the United States beginning in the 1990s.[19][73]

A 2018 longitudinal study conducted in New Zealand found only a weak association between childhood lead levels and criminal conviction, which was no longer significant after controlling for sex. In New Zealand, there is no correlation between lead exposure and socioeconomic status, thus social class does not act as a confounder. The authors conclude that "past studies of the association between BLL and crime, in which high BLL and low socioeconomic status were associated, may not have completely overcome confounding".[74][non-primary source needed] Data from the same cohort was published the next year as well and has been cited in review papers as evidence of lead poisoning having long-lasting consequences for mental health and personality.[75][76][77]

See also

References

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Further reading