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Template:PBB S-phase kinase-associated protein 2 (p45), also known as SKP2, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box^[2]. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-[[|F-box protein|F-box]]), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs^[3]. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19)^[4]^[5]. In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas^[6]. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms.

References

^ "Entrez Gene: SKP2 S-phase kinase-associated protein 2 (p45)".
^ Bai; et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. {{cite journal}}: Explicit use of et al. in: |author= (help)
^ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
^ Carrano; et al. (1999). "SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27". Nat Cell Biol. 1 (4): 193–9. doi:10.1038/12013. {{cite journal}}: Explicit use of et al. in: |author= (help)
^ Tsvetkov; et al. "p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27". Curr Biol. 9 (12): 661-4. {{cite journal}}: Explicit use of et al. in: |author= (help)
^ Latres; et al. (2001). "Role of the F-box protein Skp2 in lymphomagenesis". Proc Natl Acad Sci USA. 98 (5): 2515–20. doi:10.1073/pnas.041475098. {{cite journal}}: Explicit use of et al. in: |author= (help)

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

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[1] "Entrez Gene: SKP2 S-phase kinase-associated protein 2 (p45)".

[Bai-2] Bai; et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. {{cite journal}}: Explicit use of et al. in: |author= (help)

[Kipreos-3] Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263

[4] Carrano; et al. (1999). "SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27". Nat Cell Biol. 1 (4): 193–9. doi:10.1038/12013. {{cite journal}}: Explicit use of et al. in: |author= (help)

[5] Tsvetkov; et al. "p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27". Curr Biol. 9 (12): 661-4. {{cite journal}}: Explicit use of et al. in: |author= (help)

[6] Latres; et al. (2001). "Role of the F-box protein Skp2 in lymphomagenesis". Proc Natl Acad Sci USA. 98 (5): 2515–20. doi:10.1073/pnas.041475098. {{cite journal}}: Explicit use of et al. in: |author= (help)

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 '''S-phase kinase-associated protein 2 (p45)''', also known as '''SKP2''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: SKP2 S-phase kinase-associated protein 2 (p45)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6502| accessdate = }}</ref>
-This gene encodes a member of the [[F-box protein]] family which is characterized by an approximately 40 [[amino acid]] motif, the F-box<ref name="Bai">{{cite journal|journal=Cell|title=SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.|author= Bai et al.|date=1996|volume=86|issue=2|pages=263-74}}</ref>. The F-box [[protein]]s constitute one of the four subunits of [[ubiquitin]] protein ligase complex called [[SCF]]s ([[SKP1A|SKP1]]-[[Cul1|cullin]]-[[|F-box protein|F-box]]), which function in [[phosphorylation]]-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing [[WD-40 domains]], Fbls containing [[leucine-rich repeat]]s, and Fbxs containing either different protein-protein interaction modules or no recognizable [[Sequence motif|motifs]]<ref name="Kipreos">Kipreos ET, Pagano M. (2000). The F-box protein family. ''Genome Biol'' 1(5):REVIEWS3002. PMID 11178263 </ref>. The protein encoded by this [[gene]] belongs to the Fbls class; in addition to an F-box, this protein contains 10 [[tandem]] leucine-rich repeats. This protein is an essential element of the [[cyclin A]]-[[Cyclin-dependent kinase 2|CDK2]] [[S-phase]] [[kinase]]. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B ([[CDKN1B]], also referred to as [[p27 (gene)|p27]] or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 ([[SKP1A|SKP1]] or p19)<ref>{{cite journal|journal=Nat Cell Biol|title=SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.|author=Carrano et al|volume=1|issue=4|pages=193-9}}</ref><ref>{{cite journal|journal=Curr Biol|title=p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.|author=Tsvetkov et al|volume=9|issue=12|page=661-4}}</ref>. In addition, this gene is established as a [[protooncogene]] causally involved in the [[pathogenesis]] of [[lymphomas]]<ref>{{cite journal|journal=Proc Natl Acad Sci U S A|title=Role of the F-box protein Skp2 in lymphomagenesis.|author=Latres et al|volume=98|issue=5|pages=2515-20}}</ref>. [[Alternative splicing]] of this gene generates 2 [[transcript]] variants encoding different [[isoforms]].
+This gene encodes a member of the [[F-box protein]] family which is characterized by an approximately 40 [[amino acid]] motif, the F-box<ref name="Bai">{{cite journal|journal=Cell|title=SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.|author= Bai et al.|date=1996|volume=86|issue=2|pages=263–74|doi=10.1016/S0092-8674(00)80098-7}}</ref>. The F-box [[protein]]s constitute one of the four subunits of [[ubiquitin]] protein ligase complex called [[SCF]]s ([[SKP1A|SKP1]]-[[Cul1|cullin]]-[[|F-box protein|F-box]]), which function in [[phosphorylation]]-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing [[WD-40 domains]], Fbls containing [[leucine-rich repeat]]s, and Fbxs containing either different protein-protein interaction modules or no recognizable [[Sequence motif|motifs]]<ref name="Kipreos">Kipreos ET, Pagano M. (2000). The F-box protein family. ''Genome Biol'' 1(5):REVIEWS3002. PMID 11178263 </ref>. The protein encoded by this [[gene]] belongs to the Fbls class; in addition to an F-box, this protein contains 10 [[tandem]] leucine-rich repeats. This protein is an essential element of the [[cyclin A]]-[[Cyclin-dependent kinase 2|CDK2]] [[S-phase]] [[kinase]]. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B ([[CDKN1B]], also referred to as [[p27 (gene)|p27]] or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 ([[SKP1A|SKP1]] or p19)<ref>{{cite journal|journal=Nat Cell Biol|title=SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.|author=Carrano et al|volume=1|issue=4|pages=193–9|doi=10.1038/12013|year=1999}}</ref><ref>{{cite journal|journal=Curr Biol|title=p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.|author=Tsvetkov et al|volume=9|issue=12|page=661-4}}</ref>. In addition, this gene is established as a [[protooncogene]] causally involved in the [[pathogenesis]] of [[lymphomas]]<ref>{{cite journal|journal=Proc Natl Acad Sci USA|title=Role of the F-box protein Skp2 in lymphomagenesis.|author=Latres et al|volume=98|issue=5|pages=2515–20|doi=10.1073/pnas.041475098|year=2001}}</ref>. [[Alternative splicing]] of this gene generates 2 [[transcript]] variants encoding different [[isoforms]].
 ==References==