Neuregulin 3: Difference between revisions
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== Clinical significance == |
== Clinical significance == |
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Variants of the ''NRG3'' gene have been linked to a susceptibility to [[schizophrenia]].<ref name="pmid19118813">{{cite journal | author = Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D | title = Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia | journal = Am. J. Hum. Genet. | volume = 84 | issue = 1 | pages = 21–34 | year = 2009 | month = January | pmid = 19118813 | doi = 10.1016/j.ajhg.2008.12. |
Variants of the ''NRG3'' gene have been linked to a susceptibility to [[schizophrenia]].<ref name="pmid19118813">{{cite journal | author = Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D | title = Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia | journal = Am. J. Hum. Genet. | volume = 84 | issue = 1 | pages = 21–34 | year = 2009 | month = January | pmid = 19118813 | doi = 10.1016/j.ajhg.2008.12.00 | pmc = 2668048 | laysummary = http://www.jhunewsletter.com/2009/02/25/schizophrenia-symptom-linked-to-gene-mutation-28114/ |laysource = The Johns Hopkins News-Letter }}</ref> |
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It has also been linked to [[Hirschsprung's disease]].<ref name= |
It has also been linked to [[Hirschsprung's disease]].<ref name="pmid23315268">{{cite journal | author = Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G | title = Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population | journal = Mol. Neurobiol. | volume = | issue = | pages = | year = 2013 | month = January | pmid = 23315268 | doi = 10.1007/s12035-012-8392-4 }}</ref> |
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== References == |
== References == |
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Revision as of 16:55, 15 January 2013
Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.[1][2]
Function
NRG3 can bind to the extracellular domain of the ERBB4 receptor tyrosine kinase but not to the related family members ERBB2 or ERBB3. NRG3 binding stimulates tyrosine phosphorylation of ERBB4.[2]
Clinical significance
Variants of the NRG3 gene have been linked to a susceptibility to schizophrenia.[3]
It has also been linked to Hirschsprung's disease.[4]
References
- ^ "Entrez Gene: NRG3 neuregulin 3".
- ^ a b Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.00. PMC 2668048. PMID 19118813.
{{cite journal}}: Unknown parameter|laysource=ignored (help); Unknown parameter|laysummary=ignored (help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G (2013). "Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population". Mol. Neurobiol. doi:10.1007/s12035-012-8392-4. PMID 23315268.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
- Benzel I, Bansal A, Browning BL; et al. (2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia". Behavioral and Brain Functions. 3 (1): 31. doi:10.1186/1744-9081-3-31. PMC 1934910. PMID 17598910.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Iijima M, Tomita M, Morozumi S; et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Shrestha S, Irvin MR, Taylor KD; et al. (2010). "A genome-wide association study of carotid atherosclerosis in HIV-infected men". AIDS. 24 (4): 583–92. doi:10.1097/QAD.0b013e3283353c9e. PMID 20009918.
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{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gizatullin RZ, Muravenko OV, Al-Amin AN; et al. (2000). "Human NRG3 gene Map position 10q22-q23". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Panchal H, Wansbury O, Parry S; et al. (2007). "Neuregulin3 alters cell fate in the epidermis and mammary gland". BMC Dev. Biol. 7: 105. doi:10.1186/1471-213X-7-105. PMC 2110892. PMID 17880691.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Wang YC, Chen JY, Chen ML; et al. (2008). "Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population". Biol. Psychiatry. 64 (12): 1093–6. doi:10.1016/j.biopsych.2008.07.012. PMID 18708184.
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{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Carteron C, Ferrer-Montiel A, Cabedo H (2006). "Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival". J. Cell. Sci. 119 (Pt 5): 898–909. doi:10.1242/jcs.02799. PMID 16478787.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Gratacòs M, Costas J, de Cid R; et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
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{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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