Gary H. Posner: Difference between revisions
Content deleted Content added
Citation bot (talk | contribs) m [394]Tweak: issue. Formatted dashes. | AManWithNoPlan |
|||
| Line 5: | Line 5: | ||
==Research== |
==Research== |
||
Posner was first known for his pioneering research in [[organocopper chemistry]] in which he developed novel methods for [[organic synthesis]] involving organocopper [[reagent]]s.<ref>{{cite journal | author = Posner, Gary H. | title = Conjugate addition reactions of organocopper reagents | journal = Organic Reactions | year = 1972 | volume = 19 | pages = 1–113}}</ref><ref>{{cite journal | author = Posner, Gary H.| title = Substitution reactions using organocopper reagents | journal = Organic Reactions | year = 1975 | volume = 22 | pages = 253–400}}</ref> He is the author of the textbook ''An Introduction to Synthesis Using Organocopper Reagents''. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.<ref>{{cite journal | title = One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol |journal = Journal of Chemical Sciences | volume = 100 | issue = 2–3 | year = 1988 | doi = 10.1007/BF02839442 | pages = 81–90 | author = Gary H. Posner, Karen A. Canella and Ernest F. Silversmith | url=http://www.springerlink.com/content/5233242438540535/ |doi_brokendate = 2009-02-18}}</ref> Posner’s recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including [[isothiocyanate]]s with anticancer properties,<ref>{{cite journal | author = Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul | title = Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes| journal = Journal of Medicinal Chemistry | year = 1994 | volume = 37 | issue = 1 | pages = 170–6 | doi = 10.1021/jm00027a021 | pmid = 8289191}}</ref> new [[vitamin D]] analogs for the treatment of psoriasis,<ref>{{cite journal | author = Posner, Gary H.; Kahraman, Mehmet | title = Overview: rational design of 1α,25-dihydroxyvitamin D3 analogs (Deltanoids) | journal = Vitamin D (2nd Edition) | year = 2005 | volume = 2 | pages = 1405–1422}}</ref><ref>{{cite journal | author = Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. | title = Chemopreventive efficacy of natural vitamin D and synthetic analogs | journal = Cancer Chemoprevention | year = 2004 | pages = 259–274 | volume = 1}}</ref> and new antimalarial [[peroxide]]s.<ref>{{cite journal| author = O'Neill, Paul M.; Posner, Gary H. | title = A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides | journal = Journal of Medicinal Chemistry | year = 2004 | volume = 47 | issue = 12 | pages = 2945–2964| doi = 10.1021/jm030571c| pmid = 15163175}}</ref><ref>{{cite journal | author = Gary H. Posner, Michael H. Parker, John Northrop, Jeffrey S. Elias, Poonsakdi Ploypradith, Suji Xie, Theresa A. Shapiro | title = Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family | journal = Journal of Medicinal Chemistry | year = 1999 | volume = 42 | issue = 2 | pages = 300–304 | doi = 10.1021/jm980529v | pmid = 9925735}}</ref><ref>[http://www.eurekalert.org/pub_releases/2007-04/jhu-mmc041707.php Malaria-infected mice cured by 1 dose of new drug], 17 Apr 2007</ref> |
Posner was first known for his pioneering research in [[organocopper chemistry]] in which he developed novel methods for [[organic synthesis]] involving organocopper [[reagent]]s.<ref>{{cite journal | author = Posner, Gary H. | title = Conjugate addition reactions of organocopper reagents | journal = Organic Reactions | year = 1972 | volume = 19 | pages = 1–113}}</ref><ref>{{cite journal | author = Posner, Gary H.| title = Substitution reactions using organocopper reagents | journal = Organic Reactions | year = 1975 | volume = 22 | pages = 253–400}}</ref> He is the author of the textbook ''An Introduction to Synthesis Using Organocopper Reagents''. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.<ref>{{cite journal | title = One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol |journal = Journal of Chemical Sciences | volume = 100 | issue = 2–3 | year = 1988 | doi = 10.1007/BF02839442 | pages = 81–90 | author = Gary H. Posner, Karen A. Canella and Ernest F. Silversmith | url=http://www.springerlink.com/content/5233242438540535/ |doi_brokendate = 2009-02-18}}</ref> Posner’s recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including [[isothiocyanate]]s with anticancer properties,<ref>{{cite journal | author = Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul | title = Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes| journal = Journal of Medicinal Chemistry | year = 1994 | volume = 37 | issue = 1 | pages = 170–6 | doi = 10.1021/jm00027a021 | pmid = 8289191}}</ref> new [[vitamin D]] analogs for the treatment of psoriasis,<ref>{{cite journal | author = Posner, Gary H.; Kahraman, Mehmet | title = Overview: rational design of 1α,25-dihydroxyvitamin D3 analogs (Deltanoids) | journal = Vitamin D (2nd Edition) | year = 2005 | volume = 2 | pages = 1405–1422 | doi = 10.1016/B978-012252687-9/50084-X | isbn = 978-0-12-252687-9}}</ref><ref>{{cite journal | author = Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. | title = Chemopreventive efficacy of natural vitamin D and synthetic analogs | journal = Cancer Chemoprevention | year = 2004 | pages = 259–274 | volume = 1 | doi = 10.1007/978-1-59259-767-3_17 | isbn = 978-1-61737-342-8}}</ref> and new antimalarial [[peroxide]]s.<ref>{{cite journal| author = O'Neill, Paul M.; Posner, Gary H. | title = A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides | journal = Journal of Medicinal Chemistry | year = 2004 | volume = 47 | issue = 12 | pages = 2945–2964| doi = 10.1021/jm030571c| pmid = 15163175}}</ref><ref>{{cite journal | author = Gary H. Posner, Michael H. Parker, John Northrop, Jeffrey S. Elias, Poonsakdi Ploypradith, Suji Xie, Theresa A. Shapiro | title = Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family | journal = Journal of Medicinal Chemistry | year = 1999 | volume = 42 | issue = 2 | pages = 300–304 | doi = 10.1021/jm980529v | pmid = 9925735}}</ref><ref>[http://www.eurekalert.org/pub_releases/2007-04/jhu-mmc041707.php Malaria-infected mice cured by 1 dose of new drug], 17 Apr 2007</ref> |
||
==Awards== |
==Awards== |
||
Revision as of 23:49, 13 October 2013
Gary H. Posner (born c. 1940s) is Scowe Professor of Chemistry at Johns Hopkins University in Baltimore, Maryland.[1] Posner is known for his pioneering research in organocopper chemistry, including his involvement in the development of the Corey-House-Posner-Whitesides reaction.
Career
Posner was born in New York City and completed his undergraduate studies at Brandeis University. He received his PhD from Harvard University in 1968 where his advisor was E. J. Corey. He did a post-doctoral fellowship at the University of California Berkeley. He has been at The Johns Hopkins University since 1969 where he has held the Scowe Professorship in Chemistry since 1989.
Research
Posner was first known for his pioneering research in organocopper chemistry in which he developed novel methods for organic synthesis involving organocopper reagents.[2][3] He is the author of the textbook An Introduction to Synthesis Using Organocopper Reagents. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.[4] Posner’s recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including isothiocyanates with anticancer properties,[5] new vitamin D analogs for the treatment of psoriasis,[6][7] and new antimalarial peroxides.[8][9][10]
Awards
In 1987, Posner was named Maryland Chemist of the Year and in 1994 he received the Distinguished Teaching Award at Johns Hopkins.[1] He is also a 2004 recipient of a Cope Senior Scholar Award from the American Chemical Society.[11]
References
- ^ a b Jean and Norman Scowe Professorship in Chemistry
- ^ Posner, Gary H. (1972). "Conjugate addition reactions of organocopper reagents". Organic Reactions. 19: 1–113.
- ^ Posner, Gary H. (1975). "Substitution reactions using organocopper reagents". Organic Reactions. 22: 253–400.
- ^ Gary H. Posner, Karen A. Canella and Ernest F. Silversmith (1988). "One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol". Journal of Chemical Sciences. 100 (2–3): 81–90. doi:10.1007/BF02839442.
{{cite journal}}: Unknown parameter|doi_brokendate=ignored (|doi-broken-date=suggested) (help) - ^ Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul (1994). "Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry. 37 (1): 170–6. doi:10.1021/jm00027a021. PMID 8289191.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Posner, Gary H.; Kahraman, Mehmet (2005). "Overview: rational design of 1α,25-dihydroxyvitamin D3 analogs (Deltanoids)". Vitamin D (2nd Edition). 2: 1405–1422. doi:10.1016/B978-012252687-9/50084-X. ISBN 978-0-12-252687-9.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. (2004). "Chemopreventive efficacy of natural vitamin D and synthetic analogs". Cancer Chemoprevention. 1: 259–274. doi:10.1007/978-1-59259-767-3_17. ISBN 978-1-61737-342-8.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ O'Neill, Paul M.; Posner, Gary H. (2004). "A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides". Journal of Medicinal Chemistry. 47 (12): 2945–2964. doi:10.1021/jm030571c. PMID 15163175.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Gary H. Posner, Michael H. Parker, John Northrop, Jeffrey S. Elias, Poonsakdi Ploypradith, Suji Xie, Theresa A. Shapiro (1999). "Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family". Journal of Medicinal Chemistry. 42 (2): 300–304. doi:10.1021/jm980529v. PMID 9925735.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Malaria-infected mice cured by 1 dose of new drug, 17 Apr 2007
- ^ Arthur C. Cope Scholar Awards, American Chemical Society