Enduracididine: Difference between revisions

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Enduracididine is an α-amino acid that is non-proteinogenic. It corresponds to alanine with 2-iminoimidazolidin-4-yl group in place of a methyl hydrogen.

Biological roles

Enduracididine is not genetically encoded in protein sequences, but rather is generated as a post-translational modification. For example, enduracididine is found in the antibacterial compound teixobactin.^[1]

References

^ Ling, LL; Schneider, T; Peoples, AJ; Spoering, AL; Engels, I; Conlon, BP; Mueller, A; Schäberle, TF; Hughes, DE; Epstein, S; Jones, M; Lazarides, L; Steadman, VA; Cohen, DR; Felix, CR; Fetterman, KA; Millett, WP; Nitti, AG; Zullo, AM; Chen, C; Lewis, K (22 January 2015). "A new antibiotic kills pathogens without detectable resistance". Nature. 517 (7535): 455–9. PMID 25561178.

[Ling2015-1] Ling, LL; Schneider, T; Peoples, AJ; Spoering, AL; Engels, I; Conlon, BP; Mueller, A; Schäberle, TF; Hughes, DE; Epstein, S; Jones, M; Lazarides, L; Steadman, VA; Cohen, DR; Felix, CR; Fetterman, KA; Millett, WP; Nitti, AG; Zullo, AM; Chen, C; Lewis, K (22 January 2015). "A new antibiotic kills pathogens without detectable resistance". Nature. 517 (7535): 455–9. PMID 25561178.

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