Lynne Quarmby: Difference between revisions
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==Research and Education== |
==Research and Education== |
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Quarmby completed a BSc in Marine Biology and a MSc in Biological Oceanography at the [[University of British Columbia]] before moving to the [[University of Connecticut]] to complete her PhD in [[Biochemistry]].<ref>http://www.sfu.ca/mbb/People/Quarmby/</ref> Quarmby's research has been aimed at understanding the signals and mechanisms of deflagellation, the process by which cells shed their [[cilia]] into the environment. Cilia are found on most [[eukaryotic cells]] and on most cells in the human body, and defects in a cell's ability to form or maintain its cilia can cause diseases known as [[ciliopathies]], that may include symptoms such as [[cystic kidney disease]], [[blindness]], and [[obesity]].<ref>http://www.scientificamerican.com/article/why-scientists-are-blaming-cilia-for-human-disease/</ref> Through her research using the single-celled ciliated green alga [[Chlamydomonas reinhardtii]] as a model organism, Quarmby identified members of the NIMA-related family of [[serine/threonine kinases]] that function deflagellation<ref> |
Quarmby completed a BSc in Marine Biology and a MSc in Biological Oceanography at the [[University of British Columbia]] before moving to the [[University of Connecticut]] to complete her PhD in [[Biochemistry]].<ref name="SFU MBB Faculty Page">{{cite web|title=Lynne Quarmby|url=http://www.sfu.ca/mbb/People/Quarmby/|website=SFU Dept. of Molecular Biology and Biochemistry|accessdate=17 February 2015}}</ref> Quarmby's research has been aimed at understanding the signals and mechanisms of deflagellation, the process by which cells shed their [[cilia]] into the environment.<ref name="Cellular deflagellation">{{cite journal|last1=Quarmby|first1=Lynne M.|title=Cellular deflagellation|journal=Int Rev Cytol|date=2004|volume=233|pages=47-91|doi=10.1016/S0074-7696(04)33002-0|pmid=15037362|url=http://www.sciencedirect.com/science/article/pii/S0074769604330020|accessdate=17 February 2015}}</ref> Cilia are found on most [[eukaryotic cells]] and on most cells in the human body, and defects in a cell's ability to form or maintain its cilia can cause diseases known as [[ciliopathies]], that may include symptoms such as [[cystic kidney disease]], [[blindness]], and [[obesity]].<ref name=Ciliopathies>{{cite news|last1=Krisch|first1=Joshua A.|title=Why Scientists Are Blaming Cilia for Human Disease|url=http://www.scientificamerican.com/article/why-scientists-are-blaming-cilia-for-human-disease/|accessdate=17 February 2015|work=Scientific American|date=10 December 2014}}</ref> Through her research using the single-celled ciliated green alga [[Chlamydomonas reinhardtii]] as a model organism, Quarmby identified members of the NIMA-related family of [[serine/threonine kinases]] that function deflagellation<ref name="Deflagellation Genetics">{{cite journal|last1=Finst|first1=Rip J.|last2=Kim|first2=Peter J.|last3=Quarmby|first3=Lynne M.|title=Genetics of the deflagellation pathway in Chlamydomonas|journal=Genetics|date=1998|volume=149|issue=2|pages=927-936|pmid=9611203|accessdate=17 February 2015}}</ref><ref name="FA2 Deflagellation">{{cite journal|last1=Mahjoub|first1=Moe R.|last2=Montpetit|first2=Ben|last3=Zhao|first3=Lifan|last4=Finst|first4=Rip J.|last5=Goh|first5=Benjamin|last6=Kim|first6=Apollos C.|last7=Quarmby|first7=Lynne M.|title=The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation|journal=J Cell Sci|date=2002|volume=115|page=1759-1768|pages=1759-1768|pmid=11950892|url=http://jcs.biologists.org/content/115/8/1759.long|accessdate=17 February 2015}}</ref> as well as in the assembly and maintenance of cilia.<ref name="Quarmby NEKs">{{cite web|title=PubMed Search "Quarmby AND nima"|url=http://www.ncbi.nlm.nih.gov/pubmed/?term=%22Quarmby+LM%22%5BAuthor%5D+nima|website=PubMed|accessdate=17 February 2015}}</ref> Her group went on to show that [[NEK8]] localizes to cilia<ref name="NEK Localization">{{cite journal|last1=Mahjoub|first1=Moe R.|last2=Trapp|first2=Melissa L.|last3=Quarmby|first3=Lynne M.|title=NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes|journal=J Am Soc Nephrol|date=2005|volume=16|issue=12|pages=3485-3489|pmid=16267153|url=http://jasn.asnjournals.org/content/16/12/3485.long|accessdate=17 February 2015}}</ref>, and that mutations in NEK8 interfere with its ciliary localization<ref name="Nek8 Cystogenesis">{{cite journal|last1=Trapp|first1=Melissa L.|last2=Galtseva|first2=Alevtina|last3=Manning|first3=Danielle K.|last4=Beier|first4=David R.|last5=Rosenblum|first5=Norman D.|last6=Quarmby|first6=Lynne M.|title=Defects in ciliary localization of Nek8 is associated with cystogenesis|journal=Pediatr Nephrol|date=2008|volume=23|issue=3|pages=377-387|doi=10.1007/s00467-007-0692-y|pmid=18189147|url=http://link.springer.com/article/10.1007%2Fs00467-007-0692-y|accessdate=17 February 2015}}</ref> and cause a severe juvenile cystic kidney disease known as [[nephronophthisis]]<ref name="Human NEK8">{{cite journal|last1=Otto|first1=Edgar A.|last2=Trapp|first2=Melissa L.|last3=Schultheiss|first3=Ulla T.|last4=Helou|first4=Juliana|last5=Quarmby|first5=Lynne M.|last6=Hildebrandt|first6=Friedhelm|title=NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis|journal=J Am Soc Nephrol|date=2008|volume=19|issue=3|pages=587-592|doi=10.1681/ASN.2007040490|pmid=18199800|url=http://jasn.asnjournals.org/content/19/3/587.long|accessdate=17 February 2015}}</ref>, underscoring the important link between cilia and cystic kidney disease. |
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==Personal life== |
==Personal life== |
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Revision as of 18:59, 17 February 2015
Lynne Quarmby is a Canadian politician, academic and environmental activist. She works as a biochemistry professor at Simon Fraser University in Burnaby, British Columbia.[1][2] She has been nominated as the Green Party of Canada candidate for the newly created riding of Burnaby North—Seymour for the upcoming federal election.
Research and Education
Quarmby completed a BSc in Marine Biology and a MSc in Biological Oceanography at the University of British Columbia before moving to the University of Connecticut to complete her PhD in Biochemistry.[3] Quarmby's research has been aimed at understanding the signals and mechanisms of deflagellation, the process by which cells shed their cilia into the environment.[4] Cilia are found on most eukaryotic cells and on most cells in the human body, and defects in a cell's ability to form or maintain its cilia can cause diseases known as ciliopathies, that may include symptoms such as cystic kidney disease, blindness, and obesity.[5] Through her research using the single-celled ciliated green alga Chlamydomonas reinhardtii as a model organism, Quarmby identified members of the NIMA-related family of serine/threonine kinases that function deflagellation[6][7] as well as in the assembly and maintenance of cilia.[8] Her group went on to show that NEK8 localizes to cilia[9], and that mutations in NEK8 interfere with its ciliary localization[10] and cause a severe juvenile cystic kidney disease known as nephronophthisis[11], underscoring the important link between cilia and cystic kidney disease.
Personal life
Quarmby lives in Burnaby, British Columbia. Her adult son, Jacob Sheehy, lives in Toronto Ontario, where he runs a company called PressureNET.[12]
Activism and Politics
In May 2012, while taking part in an anti-coal protest, Quarmby was arrested along with 12 other protestors.[2] The group was attempting to block a train transporting coal for export through White Rock to Tsawwassen. After being issued $115 tickets for trespassing under the Railway Safety Act, Quarmby and the other protestors were released from police custody.[13] In November 2014, while Quarmby was involved in the protests of the Trans Mountain Oil Pipeline, she was arrested for civil contempt.[1][14] The charges were dismissed after it was discovered that Kinder Morgan provided inaccurate GPS coordinates.[15]
In December 2014, Quarmby announced that she would be seeking the Green Party of Canada nomination in Burnaby North—Seymour for the upcoming federal election.[16] She was confirmed as the candidate in January 2015.[17][18][19]
References
- ^ a b Cole, Yolande (22 January 2015). "Lynne Quarmby launches Green campaign in Burnaby North-Seymour". The Georgia Straight.
- ^ a b Quarmby, Lynne (25 October 2014). "SFU professor expecting her arrest for blockade of Kinder Morgan". Vancouver Observer.
- ^ "Lynne Quarmby". SFU Dept. of Molecular Biology and Biochemistry. Retrieved 17 February 2015.
- ^ Quarmby, Lynne M. (2004). "Cellular deflagellation". Int Rev Cytol. 233: 47–91. doi:10.1016/S0074-7696(04)33002-0. PMID 15037362. Retrieved 17 February 2015.
- ^ Krisch, Joshua A. (10 December 2014). "Why Scientists Are Blaming Cilia for Human Disease". Scientific American. Retrieved 17 February 2015.
- ^ Finst, Rip J.; Kim, Peter J.; Quarmby, Lynne M. (1998). "Genetics of the deflagellation pathway in Chlamydomonas". Genetics. 149 (2): 927–936. PMID 9611203.
{{cite journal}}:|access-date=requires|url=(help) - ^ Mahjoub, Moe R.; Montpetit, Ben; Zhao, Lifan; Finst, Rip J.; Goh, Benjamin; Kim, Apollos C.; Quarmby, Lynne M. (2002). "The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation". J Cell Sci. 115: 1759-1768. PMID 11950892. Retrieved 17 February 2015.
{{cite journal}}: More than one of|pages=and|page=specified (help) - ^ "PubMed Search "Quarmby AND nima"". PubMed. Retrieved 17 February 2015.
- ^ Mahjoub, Moe R.; Trapp, Melissa L.; Quarmby, Lynne M. (2005). "NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes". J Am Soc Nephrol. 16 (12): 3485–3489. PMID 16267153. Retrieved 17 February 2015.
- ^ Trapp, Melissa L.; Galtseva, Alevtina; Manning, Danielle K.; Beier, David R.; Rosenblum, Norman D.; Quarmby, Lynne M. (2008). "Defects in ciliary localization of Nek8 is associated with cystogenesis". Pediatr Nephrol. 23 (3): 377–387. doi:10.1007/s00467-007-0692-y. PMID 18189147. Retrieved 17 February 2015.
- ^ Otto, Edgar A.; Trapp, Melissa L.; Schultheiss, Ulla T.; Helou, Juliana; Quarmby, Lynne M.; Hildebrandt, Friedhelm (2008). "NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis". J Am Soc Nephrol. 19 (3): 587–592. doi:10.1681/ASN.2007040490. PMID 18199800. Retrieved 17 February 2015.
- ^ CBC (25 January 2015). "How your smartphone could help predict the weather". Canadian Broadcasting Corporation.
- ^ CBC News (5 May 2012). "Anti-coal protesters arrested in White Rock". Canadian Broadcasting Corporation.
- ^ Moreau, Jennifer (21 November 2014). "More arrests on Burnaby Mountain as Kinder Morgan moves in". Burnaby Now.
- ^ Keller, James and The Canadian Press (27 November 2014). "Civil contempt charges dropped against B.C. pipeline protesters". The Toronto Star.
- ^ Prystupa, Mychaylo (17 December 2014). "Kinder Morgan arrestee Lynne Quarmby to run for Greens in federal election". Vancouver Observer.
- ^ Vancouver Observer (14 January 2015). "Lynne Quarmby elected Green Party Candidate in Burnaby North-Seymour". Vancouver Observer.
- ^ Chow, Wanda (14 January 2015). "SFU's Quarmby to run for Greens in Burnaby North-Seymour". Burnaby News Leader.
- ^ Morton, Brian (19 January 2015). "SFU professor and activist acclaimed as Green candidate in Burnaby". Vancouver Sun.
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