Rajendra Kumar Sharma: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
No edit summary
Language edited and citations have been added
Line 16: Line 16:
| restingplacecoordinates =
| restingplacecoordinates =
| othername =
| othername =
| occupation = Distinguished Professor & Scientist<br>academic
| occupation = Distinguished Professor & Research Scientist<br>
| yearsactive = Since 1970
| yearsactive = Since 1970
| known for = Calmodulin regulated systems and N-myristoyltransferase
| known for = Calmodulin regulated systems and myristoylation of cellular proteins
| spouse =
| spouse =
| domesticpartner =
| domesticpartner =
| children =
| children =
| alma_mater = [[University of Saskatchewan]] (D. Sc.)
| alma_mater = [[University of Saskatchewan]] [[All India Institute of Medical Sciences]] [[Aligarh Muslim University]]
| parents =
| parents =
| website =
| website =
Line 32: Line 32:


==Biography==
==Biography==
Rajendra Sharma, the son of Venkateswar Sharma and Durga Devi Sharma, was born on January 2, 1942 in [[Hathras]], Uttar Pradesh, India. He spent his childhood in [[Hathras]] where he studied primary education at Mohan Gunj Primary Municipality School and higher secondary education at Saraswati Inter College. Dr. Sharma completed his B.Sc. in Chemistry, Botany and Zoology in 1963 and M.Sc. in Biochemistry in 1965 from [[Aligarh Muslim University]]. He served as a Chemistry lecturer at Saraswati Inter College due to the shortage of chemistry teachers during 1965. He was awarded a research fellowship from the [[Council of Scientific and Industrial Research]] (CSIR) to pursue a Ph.D. degree in Biochemistry at [[All India Institute of Medical Sciences]] (AIIMS), New Delhi, India where he worked in the area of protein chemistry and enzymology and his Ph.D. research work was published in a reputed international journal, the Journal of Biological Chemistry.<ref>{{Cite web|url=http://www.jbc.org/content/245/11/3008.short|title=Purification, Properties, and Feedback Control of l-Threonine Dehydratase from Spinach|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> After completing his Ph.D., Dr. Sharma worked as a lecturer at the Department of Biochemistry, [[Lady Hardinge Medical College]] & Hospital, New Delhi, India.
Rajendra Sharma, the son of Venkateswar Sharma and Durga Devi Sharma, was born on January 2, 1942 in [[Hathras]], Uttar Pradesh, India. He spent his childhood in [[Hathras]] where he studied primary education at Mohan Gunj Primary Municipality School and higher secondary education at Saraswati Inter College. Dr. Sharma completed his B.Sc. in Chemistry, Botany and Zoology in 1963 and M.Sc. in Biochemistry in 1965 from [[Aligarh Muslim University]]. He served as a Chemistry lecturer at Saraswati Inter College due to the shortage of chemistry teachers during 1965. He was awarded a research fellowship from the [[Council of Scientific and Industrial Research]] (CSIR) to pursue a Ph.D. degree in Biochemistry at the [[All India Institute of Medical Sciences]] (AIIMS), New Delhi, India where he worked in the area of protein chemistry and enzymology. His Ph.D. research work was published in a reputed international journal namely, the Journal of Biological Chemistry.<ref>{{Cite web|url=http://www.jbc.org/content/245/11/3008.short|title=Purification, Properties, and Feedback Control of l-Threonine Dehydratase from Spinach|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> After completing his Ph.D., Dr. Sharma worked as a lecturer at the Department of Biochemistry, [[Lady Hardinge Medical College]] & Hospital, New Delhi, India.


Dr. Sharma married to Manjul Saraswat in 1970. He was blessed with three daughters, Priya, Puja and Poonam who are now well established in their professional fields and have married Pradeep Sharma, Suneel Sharma and Anil Sharma, respectively. He has six grandchildren named, Aarika, Jiya, Iraj, Saanvi, Aaryan and Avani.
Dr. Sharma married to Manjul Saraswat in 1970. He was blessed with three daughters, Priya, Puja and Poonam who are now well established in their professional fields and have married Pradeep Sharma, Suneel Sharma and Anil Sharma, respectively. He has six grandchildren named, Aarika, Jiya, Iraj, Saanvi, Aaryan and Avani.
Line 38: Line 38:
===Scientific career===
===Scientific career===


Dr. Sharma pursued his postdoctoral research in the field of cancer biology in the Department of Biochemistry & Pharmacology in 1972, [[Tufts University School of Medicine]], Boston, Massachusetts, USA. <ref>{{Cite journal|last=|first=|date=1975|title=Study of thymidylate synthetase-function by laser Raman spectroscopy|url=https://www.sciencedirect.com/science/article/pii/0005274475901485|journal=Biochimica et Biophysica Acta (BBA) - Enzymology|language=en|volume=391|issue=1|pages=19–27|doi=10.1016/0005-2744(75)90148-5|issn=0005-2744|via=}}</ref><ref>{{Cite journal|last=|first=|date=1975|title=Quenching of thymidylate synthetases fluorescence by substrate analogs|url=|journal=Biochem Biophys Res Commun|volume=64|pages=648 655|via=}}</ref> In 1975, he joined the College of Medicine, [[University of South Alabama]] as a Research Associate at the Department of Biochemistry. As Dr. Sharma was unable to get immigration status ([[Permanent residence (United States)|green card]]) in the USA, he moved to Canada in 1976 to continue his research career at the Department of Biochemistry, Faculty of Medicine, [[University of Manitoba]], Winnipeg, Canada. He returned to India with his family in 1978 with plans to settle there, however, he could not find a job in his chosen field in India. He decided to return to Canada in 1979. Dr. Sharma again joined the Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba in 1979. Later he moved to the Department of Medical Biochemistry, University of Calgary, Alberta, Canada. He made several milestone discoveries at the University of Manitoba and the University of Calgary in the areas of [[signal transduction]].<ref>{{Cite journal|last=|first=|date=1982|title=Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for activation|url=|journal=Proc Natl Acad Sci USA|volume=78|pages=874-876|via=}}</ref><ref>{{Cite journal|last=|first=|date=1984|title=Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies|url=|journal=J Biol Chem|volume=259|pages=9248-9254|via=}}</ref><ref>{{Cite journal|last=|first=|date=1985|title=Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase|url=|journal=Proc Natl Acad Sci USA|volume=82|pages=2603-2607|via=}}</ref><ref>{{Cite journal|last=|first=|date=1990|title=Purification and characterization of novel calmodulin binding protein from cardiac muscle|url=|journal=J Biol Chem|volume=265|pages=1152 1157|via=}}</ref> In 1991, Dr. Sharma joined the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. At present, he serves as a Distinguished Professor at the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK.
Dr. Sharma pursued his postdoctoral research in the field of cancer biology in 1972 in the Department of Biochemistry & Pharmacology, [[Tufts University School of Medicine]], Boston, Massachusetts, USA. <ref>{{Cite journal|last=|first=|date=1975|title=Study of thymidylate synthetase-function by laser Raman spectroscopy|url=https://www.sciencedirect.com/science/article/pii/0005274475901485|journal=Biochimica et Biophysica Acta (BBA) - Enzymology|language=en|volume=391|issue=1|pages=19–27|doi=10.1016/0005-2744(75)90148-5|issn=0005-2744|via=}}</ref><ref>{{Cite journal|last=|first=|date=1975|title=Quenching of thymidylate synthetases fluorescence by substrate analogs|url=|journal=Biochem Biophys Res Commun|volume=64|pages=648 655|via=}}</ref> In 1975, he joined the College of Medicine, [[University of South Alabama]] as a Research Associate at the Department of Biochemistry. As Dr. Sharma was unable to get immigration status ([[Permanent residence (United States)|green card]]) in the USA, he moved to Canada in 1976 to continue his research career at the Department of Biochemistry, Faculty of Medicine, [[University of Manitoba]], Winnipeg, Canada. He returned to India with his family in 1978 with plans to settle there, however, he could not find a job in his chosen field in India. He decided to return to Canada in 1979. Dr. Sharma again joined the Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba in 1979. Later he moved to the Department of Medical Biochemistry, University of Calgary, Alberta, Canada. He made several milestone discoveries at the University of Manitoba and the University of Calgary in the areas of [[signal transduction]].<ref>{{Cite journal|last=|first=|date=1982|title=Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for activation|url=|journal=Proc Natl Acad Sci USA|volume=78|pages=874-876|via=}}</ref><ref>{{Cite journal|last=|first=|date=1984|title=Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies|url=|journal=J Biol Chem|volume=259|pages=9248-9254|via=}}</ref><ref>{{Cite journal|last=|first=|date=1985|title=Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase|url=|journal=Proc Natl Acad Sci USA|volume=82|pages=2603-2607|via=}}</ref><ref>{{Cite journal|last=|first=|date=1990|title=Purification and characterization of novel calmodulin binding protein from cardiac muscle|url=|journal=J Biol Chem|volume=265|pages=1152 1157|via=}}</ref> In 1991, Dr. Sharma joined the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. At present, he serves as a Distinguished Professor at the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK.


{{Refimprove section|date=May 2018}}
{{Refimprove section|date=May 2018}}


Dr. Sharma has made several milestone discoveries in the areas of colorectal cancer and the cardiovascular system as a whole. In particular, Dr. Sharma reported for the first time, the role of N-myrstoyltransferase in colorectoal cancer.<ref>{{cite journal|authorlink1=Bernadene A. Magnuson, Rajala V. S. Raju, Terence N. Moyana, Rajendra K. Sharma|title=Increased N -Myristoyltransferase Activity Observed in Rat and Human Colonic Tumors|journal=J. Natl. Cancer Inst.|volume=87|page=1630–1635|doi=10.1093/jnci/87.21.1630}}</ref> and his research findings in this pioneer area was also highlighted in the J. Natl. Cancer Inst.<ref>{{cite journal|authorlink1=Ronald L. Felsted, Constance J. Glover, Kathleen Hartman|title=Protein N -Myristoylation as a Chemotherapeutic Target for Cancer|journal=J.Natl. Cancer Inst.|volume=87|page=1571–1573|doi=10.1093/jnci/87.21.1571}}</ref> Later, he has identified N-myrstoyltransferase is a markers in the blood and bone marrow of patients with colorectal cancer.<ref>{{cite journal|authorlink1=Shrivastav, Anuraag, et al.|title=N-myristoyltransferase: A potential novel diagnostic marker for colon cancer|journal=J. Transl. Med.|volume=5|page=58|doi=10.1186/1479-5876-5-58}}</ref> This discovery has the potential to be developed into a simple, cost effective and accurate diagnostic for the detection of colorectal cancer. <ref>{{cite web|last1=Sharma, R.K. and Shrivastav, A.|title=Use of N-myristoyltransferase on non-tumor tissue for cancer diagnosis|url=https://patents.google.com/patent/US7892758B2/en|accessdate=15 May 2018|ref=US 7892758 B2}}</ref> Dr. Sharma’s extensive expertise in the areas involving enzymology and signal transduction has resulted in the characterization of nearly two dozen proteins from various species and establish their biological and physiological functions that has led to 264 full-length publications in reputed journals.<ref>{{cite web|last1=Sharma|first1=R. K.|title=Research Publications|url=https://scholar.google.ca/citations?hl=en&user=R2syoXsAAAAJ|accessdate=15 May 2018}}</ref> Dr.Sharma has also co-edited a book on signal transduction mechanisms published by Springer.<ref>{{cite book|title=Signal Transduction Mechanisms|publisher=Springer|url=https://www.springer.com/gp/book/9780792336631|accessdate=15 May 2018}}</ref> Dr. Sharma has gained international reputation over the last four decades for innovations and original procedures in widely disparate areas, including enzymology and signal transduction, the cardiovascular system, and brain and cancer research. His laboratory is one of the pioneer laboratories in the areas of calmodulin regulated systems and myristoylation of cellular proteins.
Dr. Sharma has gained international reputation over the last four decades for innovations and original procedures in widely disparate areas, including [[enzymology]] and signal transduction, the cardiovascular system, and brain and cancer research.<ref>{{Cite web|url=https://scholar.google.ca/citations?user=R2syoXsAAAAJ&hl=en|title=Publications|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> His laboratory is one of the pioneer laboratories in the areas of [[calmodulin]] regulated systems and [[myristoylation]] of cellular proteins. He has made several milestone discoveries in the areas of colorectal cancer and the cardiovascular system as a whole. In particular, his discovery of the role of lipid modification is likely to lead to early diagnosis and treatment of [[colorectal cancer]]<ref>{{https://academic.oup.com/jnci/article/87/21/1630/938766}}</ref> and his findings in this pioneer area was highlighted in the Journal of National Cancer Institute.<ref> {{https://academic.oup.com/jnci/article/87/21/1571/938564}}</ref> He has published 264 full-length papers in reputed journals.<ref>{{Cite web|url=https://scholar.google.ca/citations?user=R2syoXsAAAAJ&hl=en|title=Publications|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> Dr. Sharma has also co-edited a book on signal transduction mechanisms published by [[Springer Publishing|Springer]]. Dr. Sharma’s extensive expertise in the areas involving enzymology and signal transduction has resulted in the characterization of nearly two dozen proteins from various species and establish their biological and physiological functions.<ref>{{Cite web|url=https://scholar.google.ca/citations?user=R2syoXsAAAAJ&hl=en|title=Publications|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>

==References==
==References==
{{Reflist}}
{{Reflist}}

Revision as of 22:11, 15 May 2018

Rajendra Kumar Sharma
Born (1942-01-02) January 2, 1942 (age 82)
Hathras, Hathras district, Uttar Pradesh, India
Alma materUniversity of Saskatchewan All India Institute of Medical Sciences Aligarh Muslim University
Occupation(s)Distinguished Professor & Research Scientist
Years activeSince 1970
Known forCalmodulin regulated systems and myristoylation of cellular proteins
AwardsSaskatchewan Order of Merit
Saskatchewan Centennial Medal
Queen Elizabeth II Diamond Jubilee Medal
Fellow of the Royal Society of Arts, UK

Rajendra Kumar Sharma (born January 2, 1942) is a distinguished professor at the Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine.[1] He has earned several awards and medals including the Saskatchewan Order of Merit, the highest honor bestowed by the province,[2] an earned Doctor of Science from the University of Saskatchewan,[3] a Saskatchewan Centennial Medal (a one-time medal commemorating the province’s 100th anniversary),[4] and a Queen Elizabeth II Diamond Jubilee Medal.[5] Dr. Sharma was elected as a Fellow to the Royal Society of the Arts (FRSA), UK in 2014.[6] His contributions to research have been documented in the Encyclopedia of Saskatchewan – A Living Legacy.[7] Recently, the City of Saskatoon, Saskatchewan has named streets in Aspen Ridge in Saskatoon, SK in honour of Dr. Sharma (including Sharma Crescent, Sharma Lane, Sharma Way and Sharma Place) in recognition of his scholarly contributions to science and research.[8]

Biography

Rajendra Sharma, the son of Venkateswar Sharma and Durga Devi Sharma, was born on January 2, 1942 in Hathras, Uttar Pradesh, India. He spent his childhood in Hathras where he studied primary education at Mohan Gunj Primary Municipality School and higher secondary education at Saraswati Inter College. Dr. Sharma completed his B.Sc. in Chemistry, Botany and Zoology in 1963 and M.Sc. in Biochemistry in 1965 from Aligarh Muslim University. He served as a Chemistry lecturer at Saraswati Inter College due to the shortage of chemistry teachers during 1965. He was awarded a research fellowship from the Council of Scientific and Industrial Research (CSIR) to pursue a Ph.D. degree in Biochemistry at the All India Institute of Medical Sciences (AIIMS), New Delhi, India where he worked in the area of protein chemistry and enzymology. His Ph.D. research work was published in a reputed international journal namely, the Journal of Biological Chemistry.[9] After completing his Ph.D., Dr. Sharma worked as a lecturer at the Department of Biochemistry, Lady Hardinge Medical College & Hospital, New Delhi, India.

Dr. Sharma married to Manjul Saraswat in 1970. He was blessed with three daughters, Priya, Puja and Poonam who are now well established in their professional fields and have married Pradeep Sharma, Suneel Sharma and Anil Sharma, respectively. He has six grandchildren named, Aarika, Jiya, Iraj, Saanvi, Aaryan and Avani.

Scientific career

Dr. Sharma pursued his postdoctoral research in the field of cancer biology in 1972 in the Department of Biochemistry & Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, USA. [10][11] In 1975, he joined the College of Medicine, University of South Alabama as a Research Associate at the Department of Biochemistry. As Dr. Sharma was unable to get immigration status (green card) in the USA, he moved to Canada in 1976 to continue his research career at the Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. He returned to India with his family in 1978 with plans to settle there, however, he could not find a job in his chosen field in India. He decided to return to Canada in 1979. Dr. Sharma again joined the Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba in 1979. Later he moved to the Department of Medical Biochemistry, University of Calgary, Alberta, Canada. He made several milestone discoveries at the University of Manitoba and the University of Calgary in the areas of signal transduction.[12][13][14][15] In 1991, Dr. Sharma joined the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. At present, he serves as a Distinguished Professor at the Department of Pathology & Laboratory of Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK.

Dr. Sharma has made several milestone discoveries in the areas of colorectal cancer and the cardiovascular system as a whole. In particular, Dr. Sharma reported for the first time, the role of N-myrstoyltransferase in colorectoal cancer.[16] and his research findings in this pioneer area was also highlighted in the J. Natl. Cancer Inst.[17] Later, he has identified N-myrstoyltransferase is a markers in the blood and bone marrow of patients with colorectal cancer.[18] This discovery has the potential to be developed into a simple, cost effective and accurate diagnostic for the detection of colorectal cancer. [19] Dr. Sharma’s extensive expertise in the areas involving enzymology and signal transduction has resulted in the characterization of nearly two dozen proteins from various species and establish their biological and physiological functions that has led to 264 full-length publications in reputed journals.[20] Dr.Sharma has also co-edited a book on signal transduction mechanisms published by Springer.[21] Dr. Sharma has gained international reputation over the last four decades for innovations and original procedures in widely disparate areas, including enzymology and signal transduction, the cardiovascular system, and brain and cancer research. His laboratory is one of the pioneer laboratories in the areas of calmodulin regulated systems and myristoylation of cellular proteins.

References

  1. ^ "Rajendra Sharma - College of Medicine, University of Saskatchewan". medicine.usask.ca. Retrieved 2018-01-15. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  2. ^ "Saskatchewan Order of Merit | Saskatchewan Heritage, Honours, and Awards | Government of Saskatchewan". Government of Saskatchewan. Retrieved 2018-01-15.
  3. ^ "Past recipients of earned degrees - College of Graduate and Postdoctoral Studies, University of Saskatchewan". www.usask.ca. Retrieved 2018-01-15. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  4. ^ "On Campus News". news.usask.ca. Retrieved 2018-01-15.
  5. ^ General, The Office of the Secretary to the Governor. "The Governor General of Canada". Retrieved 2018-01-15.
  6. ^ RSA. "Find a Fellow - RSA". www.thersa.org. Retrieved 2018-01-15.
  7. ^ THE ENCYCLOPEDIA OF SASKATCHEWAN a Living Legacy. Regina: Canadian Plains Research Center. 2005.
  8. ^ "ASPEN RIDGE NEIGHBOURHOOD CONCEPT PLAN". {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  9. ^ "Purification, Properties, and Feedback Control of l-Threonine Dehydratase from Spinach". {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  10. ^ "Study of thymidylate synthetase-function by laser Raman spectroscopy". Biochimica et Biophysica Acta (BBA) - Enzymology. 391 (1): 19–27. 1975. doi:10.1016/0005-2744(75)90148-5. ISSN 0005-2744.
  11. ^ "Quenching of thymidylate synthetases fluorescence by substrate analogs". Biochem Biophys Res Commun. 64: 648 655. 1975.
  12. ^ "Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for activation". Proc Natl Acad Sci USA. 78: 874–876. 1982.
  13. ^ "Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies". J Biol Chem. 259: 9248–9254. 1984.
  14. ^ "Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase". Proc Natl Acad Sci USA. 82: 2603–2607. 1985.
  15. ^ "Purification and characterization of novel calmodulin binding protein from cardiac muscle". J Biol Chem. 265: 1152 1157. 1990.
  16. ^ "Increased N -Myristoyltransferase Activity Observed in Rat and Human Colonic Tumors". J. Natl. Cancer Inst. 87: 1630–1635. doi:10.1093/jnci/87.21.1630.
  17. ^ "Protein N -Myristoylation as a Chemotherapeutic Target for Cancer". J.Natl. Cancer Inst. 87: 1571–1573. doi:10.1093/jnci/87.21.1571.
  18. ^ "N-myristoyltransferase: A potential novel diagnostic marker for colon cancer". J. Transl. Med. 5: 58. doi:10.1186/1479-5876-5-58.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  19. ^ Sharma, R.K. and Shrivastav, A. "Use of N-myristoyltransferase on non-tumor tissue for cancer diagnosis". Retrieved 15 May 2018.{{cite web}}: CS1 maint: multiple names: authors list (link)
  20. ^ Sharma, R. K. "Research Publications". Retrieved 15 May 2018.
  21. ^ Signal Transduction Mechanisms. Springer. Retrieved 15 May 2018.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Rajendra_Kumar_Sharma&oldid=841446476"