Rubefacient: Difference between revisions
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A '''rubefacient''' is a substance for [[topical]] application that produces redness of the [[skin]] e.g. by causing [[Vasodilation|dilation]] of the [[capillary|capillaries]] and an increase in [[blood circulation]]. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy;<ref> |
A '''rubefacient''' is a substance for [[topical]] application that produces redness of the [[skin]] e.g. by causing [[Vasodilation|dilation]] of the [[capillary|capillaries]] and an increase in [[blood circulation]]. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy;<ref>Derry et al. 2014 [https://www.ncbi.nlm.nih.gov/pubmed/25425092 ''Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults''] Cochrane Database Syst Rev. 2014 :CD007403</ref><ref name=Mason>Mason et al. 2004 [http://www.bmj.com/cgi/content/full/328/7446/995 ''Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain''] BMJ 328:995</ref> and as of 2014 the best evidence does not support using gels and creams containing rubefacients for this purpose.<ref>{{cite journal|last=Derry|first=S|author2=Matthews, P |author3=Whiffen, PJ |author4=Moore, RA |title=Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults.|journal=Cochrane Database of Systematic Reviews|date=November 2010|issue=3|pages=CD007403|pmid=25425092|doi=10.1002/14651858.CD007403.pub3}}</ref> |
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==Examples== |
==Examples== |
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Revision as of 15:18, 4 September 2018
A rubefacient is a substance for topical application that produces redness of the skin e.g. by causing dilation of the capillaries and an increase in blood circulation. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy;[1][2] and as of 2014 the best evidence does not support using gels and creams containing rubefacients for this purpose.[3]
Examples
Common medicinal rubefacients include:[2]
- Salicylates, such as methyl salicylate (oil of wintergreen)
- Nicotinate esters
- Capsaicin, derived from chili pepper, Capsicum minimum, "incites irritation without rubefaction"
- Isopropanol (rubbing alcohol)
- Menthol
- Minoxidil
- Thurfyl nicotinate (Trafuril)
Common herbal rubefacients include:[citation needed]
- Cloves (Syzygium aromaticum)
- Garlic (Allium sativum)
- Ginger (Zingiber officinale)
- Horseradish (Cochlearia armoracia)
- Mustard (Brassica alba or Brassica nigra)
- Nettle (Urtica dioica)
- Rosemary oil (Rosmarinus officinalis)
- Rue (Ruta graveolens)
- Peppermint (Mentha piperita)
See also
References
- ^ Derry et al. 2014 Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults Cochrane Database Syst Rev. 2014 :CD007403
- ^ a b Mason et al. 2004 Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain BMJ 328:995
- ^ Derry, S; Matthews, P; Whiffen, PJ; Moore, RA (November 2010). "Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults". Cochrane Database of Systematic Reviews (3): CD007403. doi:10.1002/14651858.CD007403.pub3. PMID 25425092.