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==Education and Career==
==Education and Career==
Dan Barouch received his B.A. in Biochemistry from [[Harvard University]] in 1993. In 1995, he received his Ph.D. in immunology from [[Oxford University]] as a [[Marshall Scholar]]. In 1999, he received his M.D. from [[Harvard Medical School]]. He completed clinical residency training in internal medicine and fellowship training in infectious diseases at Massachusetts General Hospital and Brigham and Women’s Hospital in Boston.<ref>http://cvvr.hms.harvard.edu/new-page-3</ref>
Dan Barouch received his B.A. in Biochemistry from [[Harvard University]] in 1993. In 1995, he received his Ph.D. in immunology from [[Oxford University]] as a [[Marshall Scholar]]. In 1999, he received his M.D. from [[Harvard Medical School]]. He completed clinical residency training in internal medicine and fellowship training in infectious diseases at Massachusetts General Hospital and Brigham and Women’s Hospital in Boston.<ref name="cvv">{{Cite web|url=http://cvvr.hms.harvard.edu/new-page-3|title=biography|website=Center for Virology and Vaccine Research}}</ref>
Barouch is a Professor of Medicine and Professor of Immunology at Harvard Medical School.<ref>https://www.lgbtqnation.com/2019/07/new-vaccine-hiv-work-worldwide-expanding-human-testing-america/</ref> In 2012, he was named the founding Director of the Center for Virology and Vaccine Research at [[Beth Israel Deaconess Medical Center]] in Boston.<ref>https://www.bostonglobe.com/lifestyle/health-wellness/2012/08/21/dan-barouch-lead-beth-israel-center-focused-vaccine-research/zSkc2cWInRoBLrLJzhntDL/story.html</ref><ref>https://www.sciencedaily.com/releases/2018/07/180707090650.htm</ref> He is also a founding member and a steering committee member at the [[Ragon Institute]] of Massachusetts General Hospital, [[Massachusetts Institute of Technology]], and Harvard University.<ref name=Harvard>https://hms.harvard.edu/news/hiv-vaccine-takes-big-step</ref><ref>https://medicalxpress.com/news/2013-10-monoclonal-antibodies-effective-hiv-therapy.html</ref>
Barouch is a Professor of Medicine and Professor of Immunology at Harvard Medical School.<ref>{{Cite web|url=https://www.lgbtqnation.com/2019/07/new-vaccine-hiv-work-worldwide-expanding-human-testing-america/|title=A new vaccine for HIV that would work worldwide is expanding human testing to America|first=Bil|last=Browning|date=July 12, 2019|website=www.lgbtqnation.com}}</ref> In 2012, he was named the founding Director of the Center for Virology and Vaccine Research at [[Beth Israel Deaconess Medical Center]] in Boston.<ref>{{Cite web|url=https://www.bostonglobe.com/lifestyle/health-wellness/2012/08/21/dan-barouch-lead-beth-israel-center-focused-vaccine-research/zSkc2cWInRoBLrLJzhntDL/story.html|title=Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - The Boston Globe|website=BostonGlobe.com}}</ref><ref>{{Cite web|url=https://www.sciencedaily.com/releases/2018/07/180707090650.htm|title=Novel HIV vaccine candidate is safe and induces immune response in healthy adults and monkeys|website=ScienceDaily}}</ref> He is also a founding member and a steering committee member at the [[Ragon Institute]] of Massachusetts General Hospital, [[Massachusetts Institute of Technology]], and Harvard University.<ref name="Harvard">{{Cite web|url=https://hms.harvard.edu/news/hiv-vaccine-takes-big-step|title=HIV Vaccine Takes Big Step &#124; Harvard Medical School|website=hms.harvard.edu}}</ref><ref>{{Cite web|url=https://medicalxpress.com/news/2013-10-monoclonal-antibodies-effective-hiv-therapy.html|title=Monoclonal antibodies show promise as effective HIV therapy|website=medicalxpress.com}}</ref>


==HIV research==
==HIV research==
Barouch started HIV research while he was still in medical school and launched his independent research laboratory at age 29. He has developed several vaccination platforms, including adjuvanted DNA vaccines and adenoviral vectors.<ref>https://books.google.ca/books?id=Fs4rDwAAQBAJ&pg=PA179</ref>
Barouch started HIV research while he was still in medical school and launched his independent research laboratory at age 29. He has developed several vaccination platforms, including adjuvanted DNA vaccines and adenoviral vectors.<ref>{{Cite web|url=https://books.google.ca/books?id=Fs4rDwAAQBAJ&pg=PA179|title=The End of Epidemics: The Looming Threat to Humanity and How to Stop It|first1=Dr Jonathan D.|last1=Quick|first2=Bronwyn|last2=Fryer|date=January 30, 2018|publisher=St. Martin's Publishing Group|via=Google Books}}</ref>


In 2000, Barouch began researching the development an HIV vaccine.<ref>https://books.google.ca/books?id=58GFGtyaCrIC&pg=PA155</ref> In 2002, he published that a candidate HIV vaccine can suppress virus in preclinical studies for a period of two years.<ref>https://books.google.ca/books?id=02UEAAAAMBAJ&pg=PA11</ref> In 2006, he developed a vaccine vector that was not suppressed by preexisting immunity.<ref>{{cite article |title=The Finding|publisher=The Scientist |page=63 |year=2008 |url=https://books.google.ca/books?id=FYQ-AQAAIAAJ&q=Dan+Barouch}}</ref> His research between 2004 and 2019 provided the scientific foundation for the Johnson & Johnson HIV vaccine candidate, including the creation of a set of “mosaic” proteins with Bette Korber, which improve immune responses against multiple strains of the virus.<ref name=Harvard /><ref>https://www.nydailynews.com/news/world/ny-hiv-vaccine-test-united-states-europe-johnson-johnson-20190713-swb2kyypbbfehnsmbgoy27efby-story.html</ref> From 2015-2018, Barouch co-led the HIV-V-0004 APPROACH study,<ref>https://www.healthline.com/health-news/latest-hiv-vaccine-candidate-is-best-yet#7</ref> testing the mosaic Ad26/Env vaccine in human subjects.<ref>https://books.google.ca/books?id=qBT1DQAAQBAJ&pg=PA100</ref> This vaccine was then advanced into clinical efficacy trials in Africa, North America, South America, and Europe with the [[National Institutes of Health]], the [[Bill & Melinda Gates Foundation]], Janssen, and others.<ref>https://hms.harvard.edu/news/hiv-vaccine-takes-big-step</ref><ref>https://www.nature.com/articles/d41586-019-02319-8</ref>
In 2000, Barouch began researching the development an HIV vaccine.<ref>{{Cite web|url=https://books.google.ca/books?id=58GFGtyaCrIC&pg=PA155|title=Combating AIDS: Communication Strategies in Action|first1=Arvind|last1=Singhal|first2=Everett M.|last2=Rogers|first3=Dr Everett M.|last3=Rogers|date=October 3, 2003|publisher=SAGE|via=Google Books}}</ref> In 2002, he published that a candidate HIV vaccine can suppress virus in preclinical studies for a period of two years.<ref>https://books.google.ca/books?id=02UEAAAAMBAJ&pg=PA11</ref> In 2006, he developed a vaccine vector that was not suppressed by preexisting immunity.<ref>{{cite article |title=The Finding|publisher=The Scientist |page=63 |year=2008 |url=https://books.google.ca/books?id=FYQ-AQAAIAAJ&q=Dan+Barouch}}</ref> His research between 2004 and 2019 provided the scientific foundation for the Johnson & Johnson HIV vaccine candidate, including the creation of a set of “mosaic” proteins with Bette Korber, which improve immune responses against multiple strains of the virus.<ref name=Harvard /><ref>{{Cite web|url=https://www.nydailynews.com/news/world/ny-hiv-vaccine-test-united-states-europe-johnson-johnson-20190713-swb2kyypbbfehnsmbgoy27efby-story.html|title=Johnson & Johnson to start testing on new type of HIV vaccine in U.S. and Europe|first=Muri|last=Assunção|website=nydailynews.com}}</ref> From 2015-2018, Barouch co-led the HIV-V-0004 APPROACH study,<ref>{{Cite web|url=https://www.healthline.com/health-news/latest-hiv-vaccine-candidate-is-best-yet|title=HIV Vaccine Latest Test Results|website=Healthline}}</ref> testing the mosaic Ad26/Env vaccine in human subjects.<ref>{{Cite web|url=https://books.google.ca/books?id=qBT1DQAAQBAJ&pg=PA100|title=The CAPRISA Clinical Trials: HIV Treatment and Prevention|first1=Quarraisha Abdool|last1=Karim|first2=Salim S. Abdool|last2=Karim|first3=Cheryl|last3=Baxter|date=January 20, 2017|publisher=Springer|via=Google Books}}</ref> This vaccine was then advanced into clinical efficacy trials in Africa, North America, South America, and Europe with the [[National Institutes of Health]], the [[Bill & Melinda Gates Foundation]], Janssen, and others.<ref name="Harvard"/><ref>{{Cite journal|url=http://www.nature.com/articles/d41586-019-02319-8|title=‘Mosaic’ HIV vaccine to be tested in thousands of people across the world|first=Emiliano Rodríguez|last=Mega|date=July 31, 2019|journal=Nature|volume=572|pages=165–166|via=www.nature.com|doi=10.1038/d41586-019-02319-8}}</ref>


Barouch has also worked on immunologic strategies to cure HIV infection.<ref>https://www.reuters.com/article/us-health-aids-cure-analysis/worlds-second-man-cleared-of-aids-virus-invigorates-quest-for-cure-idUSKCN1QN1TK</ref> In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with immune activators, also known as the “shock and kill” strategy.<ref>https://www.sciencemag.org/news/2018/03/monkeys-reveal-new-clues-toward-elusive-hiv-vaccine-and-cure</ref> Barouch has also discussed his research and has commented on the research of others in the media.<ref>https://www.aidsmap.com/news/jul-2019/promising-hiv-vaccine-be-tested-gay-men-and-trans-people</ref>
Barouch has also worked on immunologic strategies to cure HIV infection.<ref>{{Cite web|url=https://www.reuters.com/article/us-health-aids-cure-analysis-idUSKCN1QN1TK|title=World's second man cleared of AIDS virus invigorates quest for cure|date=March 6, 2019|via=www.reuters.com}}</ref> In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with immune activators, also known as the “shock and kill” strategy.<ref>{{Cite web|url=https://www.sciencemag.org/news/2018/03/monkeys-reveal-new-clues-toward-elusive-hiv-vaccine-and-cure|title=Monkeys reveal new clues toward elusive HIV vaccine and cure|date=March 9, 2018|website=Science &#124; AAAS}}</ref> Barouch has also discussed his research and has commented on the research of others in the media.<ref>https://www.aidsmap.com/news/jul-2019/promising-hiv-vaccine-be-tested-gay-men-and-trans-people</ref>


==Zika research==
==Zika research==
In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies.<ref>https://www.bostonglobe.com/magazine/2016/12/14/dan-barouch-and-jim-collins-the-researchers-racing-stop-zika/7ZkCMED5Pf33Co8Xm6kohP/story.html</ref><ref>https://www.newyorker.com/magazine/2016/08/22/the-race-for-a-zika-vaccine</ref> These vaccines entered first-in-human trials later that year.<ref>https://www.telegraph.co.uk/science/2016/08/04/zika-vaccine-gives-complete-protection-and-is-ready-for-human-tr/</ref>
In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies.<ref name="auto">{{Cite web|url=https://www.bostonglobe.com/magazine/2016/12/14/dan-barouch-and-jim-collins-the-researchers-racing-stop-zika/7ZkCMED5Pf33Co8Xm6kohP/story.html|title=Dan Barouch and Jim Collins: The researchers racing to stop Zika - The Boston Globe|website=BostonGlobe.com}}</ref><ref>{{Cite web|url=https://www.newyorker.com/magazine/2016/08/22/the-race-for-a-zika-vaccine|title=The Race for a Zika Vaccine|first=Siddhartha|last=Mukherjee|date=August 15, 2016|via=www.newyorker.com}}</ref> These vaccines entered first-in-human trials later that year.<ref>{{Cite web|url=https://www.telegraph.co.uk/science/2016/08/04/zika-vaccine-gives-complete-protection-and-is-ready-for-human-tr/|title=Zika vaccine gives complete protection and is ready for human trials, say scientists|first=Sarah|last=Knapton|date=August 4, 2016|via=www.telegraph.co.uk}}</ref>


==Societies and awards==
==Societies and awards==
In 2009, Barouch was elected to the [[American Society for Clinical Investigation]].<ref>https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500668</ref> In 2013, he became a member of the [[Association of American Physicians]].<ref name=cvv>http://cvvr.hms.harvard.edu/new-page-3</ref> In 2016, Barouch was named Honorary Researcher at the Centre de Recherche, [[Centre hospitalier de l'Université de Montréal]]<ref>https://www.chumontreal.qc.ca/en/crchum/researchers/dan-h-barouch</ref> and was named a Bostonian of the Year by the ''[[Boston Globe Magazine]]''.<ref>https://www.bostonglobe.com/magazine/2016/12/14/dan-barouch-and-jim-collins-the-researchers-racing-stop-zika/7ZkCMED5Pf33Co8Xm6kohP/story.html</ref> In 2017, Barouch was named the Investigator of the Year by the Massachusetts Society for Medical Research and received the Drexel Prize in Immunology from the [[Drexel University]] College of Medicine. In 2019, Barouch received the Best Academic Research Team Vaccine Industry Excellence Award at the World Vaccine Congress.<ref name=cvv />
In 2009, Barouch was elected to the [[American Society for Clinical Investigation]].<ref>{{Cite web|url=https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500668|title=The American Society for Clinical Investigation}}</ref> In 2013, he became a member of the [[Association of American Physicians]].<ref name="cvv"/> In 2016, Barouch was named Honorary Researcher at the Centre de Recherche, [[Centre hospitalier de l'Université de Montréal]]<ref>{{Cite web|url=https://www.chumontreal.qc.ca/en/crchum/researchers/dan-h-barouch|title=Barouch, Dan H. &#124; CHUM|website=www.chumontreal.qc.ca}}</ref> and was named a Bostonian of the Year by the ''[[Boston Globe Magazine]]''.<ref name="auto"/> In 2017, Barouch was named the Investigator of the Year by the Massachusetts Society for Medical Research and received the Drexel Prize in Immunology from the [[Drexel University]] College of Medicine. In 2019, Barouch received the Best Academic Research Team Vaccine Industry Excellence Award at the World Vaccine Congress.<ref name=cvv />


==References==
==References==

Revision as of 05:41, 3 October 2019

Dan Barouch
CitizenshipAmerican
EducationM.D. and Ph.D.
Alma materHarvard and Oxford
AwardsDrexel Prize in Immunology

Dan Barouch is an American physician, immunologist, and virologist. He is known for his work on the pathogenesis and immunology of viral infections and the development of vaccine strategies for global infectious diseases.

Education and Career

Dan Barouch received his B.A. in Biochemistry from Harvard University in 1993. In 1995, he received his Ph.D. in immunology from Oxford University as a Marshall Scholar. In 1999, he received his M.D. from Harvard Medical School. He completed clinical residency training in internal medicine and fellowship training in infectious diseases at Massachusetts General Hospital and Brigham and Women’s Hospital in Boston.[1] Barouch is a Professor of Medicine and Professor of Immunology at Harvard Medical School.[2] In 2012, he was named the founding Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston.[3][4] He is also a founding member and a steering committee member at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University.[5][6]

HIV research

Barouch started HIV research while he was still in medical school and launched his independent research laboratory at age 29. He has developed several vaccination platforms, including adjuvanted DNA vaccines and adenoviral vectors.[7]

In 2000, Barouch began researching the development an HIV vaccine.[8] In 2002, he published that a candidate HIV vaccine can suppress virus in preclinical studies for a period of two years.[9] In 2006, he developed a vaccine vector that was not suppressed by preexisting immunity.[10] His research between 2004 and 2019 provided the scientific foundation for the Johnson & Johnson HIV vaccine candidate, including the creation of a set of “mosaic” proteins with Bette Korber, which improve immune responses against multiple strains of the virus.[5][11] From 2015-2018, Barouch co-led the HIV-V-0004 APPROACH study,[12] testing the mosaic Ad26/Env vaccine in human subjects.[13] This vaccine was then advanced into clinical efficacy trials in Africa, North America, South America, and Europe with the National Institutes of Health, the Bill & Melinda Gates Foundation, Janssen, and others.[5][14]

Barouch has also worked on immunologic strategies to cure HIV infection.[15] In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with immune activators, also known as the “shock and kill” strategy.[16] Barouch has also discussed his research and has commented on the research of others in the media.[17]

Zika research

In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies.[18][19] These vaccines entered first-in-human trials later that year.[20]

Societies and awards

In 2009, Barouch was elected to the American Society for Clinical Investigation.[21] In 2013, he became a member of the Association of American Physicians.[1] In 2016, Barouch was named Honorary Researcher at the Centre de Recherche, Centre hospitalier de l'Université de Montréal[22] and was named a Bostonian of the Year by the Boston Globe Magazine.[18] In 2017, Barouch was named the Investigator of the Year by the Massachusetts Society for Medical Research and received the Drexel Prize in Immunology from the Drexel University College of Medicine. In 2019, Barouch received the Best Academic Research Team Vaccine Industry Excellence Award at the World Vaccine Congress.[1]

References

  1. ^ a b c "biography". Center for Virology and Vaccine Research.
  2. ^ Browning, Bil (July 12, 2019). "A new vaccine for HIV that would work worldwide is expanding human testing to America". www.lgbtqnation.com.
  3. ^ "Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - The Boston Globe". BostonGlobe.com.
  4. ^ "Novel HIV vaccine candidate is safe and induces immune response in healthy adults and monkeys". ScienceDaily.
  5. ^ a b c "HIV Vaccine Takes Big Step | Harvard Medical School". hms.harvard.edu.
  6. ^ "Monoclonal antibodies show promise as effective HIV therapy". medicalxpress.com.
  7. ^ Quick, Dr Jonathan D.; Fryer, Bronwyn (January 30, 2018). "The End of Epidemics: The Looming Threat to Humanity and How to Stop It". St. Martin's Publishing Group – via Google Books.
  8. ^ Singhal, Arvind; Rogers, Everett M.; Rogers, Dr Everett M. (October 3, 2003). "Combating AIDS: Communication Strategies in Action". SAGE – via Google Books.
  9. ^ https://books.google.ca/books?id=02UEAAAAMBAJ&pg=PA11
  10. ^ Template:Cite article
  11. ^ Assunção, Muri. "Johnson & Johnson to start testing on new type of HIV vaccine in U.S. and Europe". nydailynews.com.
  12. ^ "HIV Vaccine Latest Test Results". Healthline.
  13. ^ Karim, Quarraisha Abdool; Karim, Salim S. Abdool; Baxter, Cheryl (January 20, 2017). "The CAPRISA Clinical Trials: HIV Treatment and Prevention". Springer – via Google Books.
  14. ^ Mega, Emiliano Rodríguez (July 31, 2019). "'Mosaic' HIV vaccine to be tested in thousands of people across the world". Nature. 572: 165–166. doi:10.1038/d41586-019-02319-8 – via www.nature.com.
  15. ^ "World's second man cleared of AIDS virus invigorates quest for cure". March 6, 2019 – via www.reuters.com.
  16. ^ "Monkeys reveal new clues toward elusive HIV vaccine and cure". Science | AAAS. March 9, 2018.
  17. ^ https://www.aidsmap.com/news/jul-2019/promising-hiv-vaccine-be-tested-gay-men-and-trans-people
  18. ^ a b "Dan Barouch and Jim Collins: The researchers racing to stop Zika - The Boston Globe". BostonGlobe.com.
  19. ^ Mukherjee, Siddhartha (August 15, 2016). "The Race for a Zika Vaccine" – via www.newyorker.com.
  20. ^ Knapton, Sarah (August 4, 2016). "Zika vaccine gives complete protection and is ready for human trials, say scientists" – via www.telegraph.co.uk.
  21. ^ "The American Society for Clinical Investigation".
  22. ^ "Barouch, Dan H. | CHUM". www.chumontreal.qc.ca.
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