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'''Donald L. Price''' (born c. 1935) is an American neuropathologist and professor at the [[Johns Hopkins School of Medicine]]. He was born in Stamford, Connecticut. He attended [[Wesleyan University]], where he received a Bachelor’s of Arts in [[English literature|English Literature]]. In 1961, he graduated from [[Albany Medical College]] of [[Union University]], where he received a Master’s Degree. He and his wife have three children, all of whom currently practice medicine.<ref name=":0">{{Cite web|url=http://pathology.jhu.edu/department/priceResearchFund.pdf|title=The Donald L. Price Research Fund|last=|first=|date=May 18, 2008|website=John Hopkins Medicine|url-status=live|archive-url=|archive-date=|access-date=}}</ref>
== Donald L. Price ==
⚫
'''Donald L. Price''' (c. 1935) is an American neuropathologist and professor at the [[Johns Hopkins School of Medicine]]. He was born in Stamford, Connecticut. He attended [[Wesleyan University]], where he received a Bachelor’s of Arts in [[English literature|English Literature]]. In 1961, he graduated from [[Albany Medical College]] of [[Union University]], where he received a Master’s Degree. He and his wife have three children, all of whom currently practice medicine.<ref name=":0">{{Cite web|url=http://pathology.jhu.edu/department/priceResearchFund.pdf|title=The Donald L. Price Research Fund|last=|first=|date=May 18, 2008|website=John Hopkins Medicine|url-status=live|archive-url=|archive-date=|access-date=}}</ref>


=== Career/Research ===
== Career and research ==
⚫
[[File:TANGLES_HIGH.jpg|thumb|Defects in the Brain due to Alzheimer's disease]]
After graduating from Albany Medical School of Union University, Price received a [[Postdoctoral fellowship|Postdoctoral Fellowship]] studying Cellular/[[Molecular biology|Molecular Biology]] at [[Harvard University]]. He later became an assistant professor in the Departments of [[Neurology]] and [[Pathology]] at Harvard Medical School in 1970. A year later, he became an associate professor at Johns Hopkins University. In 1990, he served as the President of [[American Association of Neuropathologists]]<ref>{{Cite web|url=https://www.neuropath.org/past-presidents|title=Past Presidents and Officers|website=www.neuropath.org|access-date=2020-03-30}}</ref>. From 2000-2001, he served as the President of the [[Society for Neuroscience]]<ref>{{Cite web|url=https://www.sfn.org/about/volunteer-leadership/sfn-presidents|title=SfN Presidents|website=www.sfn.org|language=en|access-date=2020-03-30}}</ref>.
After graduating from Albany Medical School of Union University, Price received a [[Postdoctoral fellowship|Postdoctoral Fellowship]] studying Cellular/[[Molecular biology|Molecular Biology]] at [[Harvard University]]. He later became an assistant professor in the Departments of [[Neurology]] and [[Pathology]] at Harvard Medical School in 1970. A year later, he became an associate professor at Johns Hopkins University. In 1990, he served as the President of [[American Association of Neuropathologists]]<ref>{{Cite web|url=https://www.neuropath.org/past-presidents|title=Past Presidents and Officers|website=www.neuropath.org|access-date=2020-03-30}}</ref>. From 2000-2001, he served as the President of the [[Society for Neuroscience]]<ref>{{Cite web|url=https://www.sfn.org/about/volunteer-leadership/sfn-presidents|title=SfN Presidents|website=www.sfn.org|language=en|access-date=2020-03-30}}</ref>.


In his early research years, Price focused on the biology of motor neurons, but later in his life, he expanded in his research interests and became more known for researching neurobiology and the mechanisms of the brain. Throughout his life, Price explored different experiments and studies, mainly including the study of animal models in order to “allow a more direct insight into [[pathogenesis]]” rather than using human models. Dr. Price’s research interests involve “age-associated neurodegenerative diseases, particularly [<nowiki/>[[Alzheimer's disease|Alzheimer’s Disease]]]”<ref name=":1">{{Cite journal|last=Troncoso|first=Juan|date=2012-11-01|title=Meritorious Contributions to Neuropathology|url=https://academic.oup.com/jnen/article/71/11/1030/2917391|journal=Journal of Neuropathology & Experimental Neurology|language=en|volume=71|issue=11|pages=1030–1031|doi=10.1097/NEN.0b013e318273643e|issn=0022-3069}}</ref>. He has received support from numerous foundations on his research for Alzheimer’s disease. In 1985, he became the [[Principal investigator|Principal Investigator]] of the Alzheimer’s Disease Research Center.
In his early research years, Price focused on the biology of motor neurons, but later in his life, he expanded in his research interests and became more known for researching neurobiology and the mechanisms of the brain. Throughout his life, Price explored different experiments and studies, mainly including the study of animal models in order to “allow a more direct insight into [[pathogenesis]]” rather than using human models. Dr. Price’s research interests involve “age-associated neurodegenerative diseases, particularly [<nowiki/>[[Alzheimer's disease|Alzheimer’s Disease]]]”<ref name=":1">{{Cite journal|last=Troncoso|first=Juan|date=2012-11-01|title=Meritorious Contributions to Neuropathology|url=https://academic.oup.com/jnen/article/71/11/1030/2917391|journal=Journal of Neuropathology & Experimental Neurology|language=en|volume=71|issue=11|pages=1030–1031|doi=10.1097/NEN.0b013e318273643e|issn=0022-3069}}</ref>. He has received support from numerous foundations on his research for Alzheimer’s disease. In 1985, he became the [[Principal investigator|Principal Investigator]] of the Alzheimer’s Disease Research Center.


Further, Price’s research has a focus on treatment for [[Neurodegeneration|neurodegenerative]] conditions. His work with transgenic mice seeks to experimentally test new treatment mechanisms before they reach human subjects<ref>{{Cite journal|last=Price|first=D. L.|last2=Tanzi|first2=R. E.|last3=Borchelt|first3=D. R.|last4=Sisodia|first4=S. S.|date=1998|title=Alzheimer's disease: genetic studies and transgenic models|url=https://www.ncbi.nlm.nih.gov/pubmed/9928488|journal=Annual Review of Genetics|volume=32|pages=461–493|doi=10.1146/annurev.genet.32.1.461|issn=0066-4197|pmid=9928488}}</ref>. These studies have identified specific genes that are often risk factors, particularly [[amyloid]]-prone genes, and attempted to correlate them to particular behaviors associated with Alzheimer’s Disease. For example, his research has concluded that mutations to amyloid precursor proteins are linked to memory loss. Studies like these ultimately aim to identify new targets for treatment of the disease.
Further, Price’s research has a focus on treatment for [[Neurodegeneration|neurodegenerative]] conditions. His work with transgenic mice seeks to experimentally test new treatment mechanisms before they reach human subjects<ref>{{Cite journal|last=Price|first=D. L.|last2=Tanzi|first2=R. E.|last3=Borchelt|first3=D. R.|last4=Sisodia|first4=S. S.|date=1998|title=Alzheimer's disease: genetic studies and transgenic models|journal=Annual Review of Genetics|volume=32|pages=461–493|doi=10.1146/annurev.genet.32.1.461|issn=0066-4197|pmid=9928488}}</ref>. These studies have identified specific genes that are often risk factors, particularly [[amyloid]]-prone genes, and attempted to correlate them to particular behaviors associated with Alzheimer’s Disease. For example, his research has concluded that mutations to amyloid precursor proteins are linked to memory loss. Studies like these ultimately aim to identify new targets for treatment of the disease.


Price took part in the publication of the Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology text <ref>Wong, Philip & Li, Tong & Price, Donald. (2012). Neurobiology of Alzheimer's Disease. Basic Neurochemistry. 781-790. 10.1016/B978-0-12-374947-5.00046-8.</ref>. Within the text, he worked with colleagues such as [[Philip C. Wong]] and [[Tong Li]] to write a chapter that focuses on Alzheimer’s disease and how it leads to major defects within the brain. Alzheimer’s disease (AD) is one of Price’s most researched topics. The disease causes people to have progressive memory loss and also problems with cognitive development. The neuroscience behind AD is characterized by neuronal loss, which means the failure of functioning neurons, or the lack of [[neurofibrillary tangles]] within parts of the brain. The neurofibrillary tangles (NFTs) were most commonly found in the central superior nucleus and they help determine the duration of the disease. Patients who had a longer duration of AD had less NFTs than patients who had a shorter duration of AD. The number of NFTs in the nuclei reflect on how the rate of progression, so if a small number of NFTs are found, then they have a greater chance of becoming better. This disease affects the person’s everyday life due to the decline in cognitive abilities and memory loss. In cases of AD, there are various kinds of techniques used to detect any impairments or defects within the brain. One of the techniques used is a [[functional magnetic resonance imaging]] (fMRI) which are most likely used to detect any evidence of atrophy with relation to the [[hippocampus]] and [[entorhinal cortex]]. Another technique is called [[positron emission tomography]] (PET) and is used to look within the parietal and temporal lobes to detect any decreased glucose or blood flow. Alzheimer’s Disease, overall, has many symptoms that involve abnormalities within different parts of the brain that are important for memory storage and cognitive development. Price expands his interest and knowledge towards this neurodegenerative disease in most of his research. <gallery>
Price took part in the publication of the Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology text <ref>Wong, Philip & Li, Tong & Price, Donald. (2012). Neurobiology of Alzheimer's Disease. Basic Neurochemistry. 781-790. 10.1016/B978-0-12-374947-5.00046-8.</ref>. Within the text, he worked with colleagues such as [[Philip C. Wong]] and [[Tong Li]] to write a chapter that focuses on Alzheimer’s disease and how it leads to major defects within the brain. Alzheimer’s disease (AD) is one of Price’s most researched topics. The disease causes people to have progressive memory loss and also problems with cognitive development. The neuroscience behind AD is characterized by neuronal loss, which means the failure of functioning neurons, or the lack of [[neurofibrillary tangles]] within parts of the brain. The neurofibrillary tangles (NFTs) were most commonly found in the central superior nucleus and they help determine the duration of the disease. Patients who had a longer duration of AD had less NFTs than patients who had a shorter duration of AD. The number of NFTs in the nuclei reflect on how the rate of progression, so if a small number of NFTs are found, then they have a greater chance of becoming better. This disease affects the person’s everyday life due to the decline in cognitive abilities and memory loss. In cases of AD, there are various kinds of techniques used to detect any impairments or defects within the brain. One of the techniques used is a [[functional magnetic resonance imaging]] (fMRI) which are most likely used to detect any evidence of atrophy with relation to the [[hippocampus]] and [[entorhinal cortex]]. Another technique is called [[positron emission tomography]] (PET) and is used to look within the parietal and temporal lobes to detect any decreased glucose or blood flow. Alzheimer’s Disease, overall, has many symptoms that involve abnormalities within different parts of the brain that are important for memory storage and cognitive development. Price expands his interest and knowledge towards this neurodegenerative disease in most of his research.
⚫
TANGLES_HIGH.jpg|Defects in the Brain due to Alzheimer's disease
⚫
</gallery> In addition to all of his research accomplishments and accolades, he has mentored many prominent physicians and investigators at the Johns Hopkins University’s Neuropathology Division to become important leaders in the field of neurobiology of diseases. Some notable physicians and investigators include Carlos Porteria-Cailliau, Naomi E. Rance, Charles White III, David R. Borchet, and Lee J. Martin<ref>{{Cite web|url=https://neurotree.org/beta/tree.php?pid=14831&cnodecount=3&pnodecount=4|title=Neurotree - Donald L. Price Family Tree|website=neurotree.org|access-date=2020-03-30}}</ref>.


⚫
He has mentored several prominent physicians and investigators at the Johns Hopkins University’s Neuropathology Division to become important leaders in the field of neurobiology of diseases. Some notable physicians and investigators include Carlos Porteria-Cailliau, Naomi E. Rance, Charles White III, David R. Borchet, and Lee J. Martin<ref>{{Cite web|url=https://neurotree.org/beta/tree.php?pid=14831&cnodecount=3&pnodecount=4|title=Neurotree - Donald L. Price Family Tree|website=neurotree.org|access-date=2020-03-30}}</ref>.
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=== Awards/honors ===

⚫
== Awards and honors ==
{| class="wikitable"
{| class="wikitable"
|-
|-
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| 1990 || President of the American Association of Neuropathologists
| 1990 || President of the American Association of Neuropathologists
|-
|-
| 1992 || Potamkin Prize for Alzheimer’s Disease Research<ref>{{Citation|title=Potamkin Prize|date=2020-01-21|url=https://en.wikipedia.org/w/index.php?title=Potamkin_Prize&oldid=936925919|work=Wikipedia|language=en|access-date=2020-03-30}}</ref>
| 1992 || Potamkin Prize for Alzheimer’s Disease Research
|-
|-
| 1994 || Leadership in Alzheimer’s Disease (LEAD) Award (National Institute of Aging)
| 1994 || Leadership in Alzheimer’s Disease (LEAD) Award (National Institute of Aging)
Line 37: Line 37:
|}
|}


=== Publications ===
== Publications ==


Price was placed in the top ten authors of high impact papers in Neuroscience from 1990-200 due to writing over 500 publications and over 200 book chapters. The list below are some of his most cited publications <ref name=":1" />:
Price was placed in the top ten authors of high impact papers in Neuroscience from 1990-200 due to writing over 500 publications and over 200 book chapters. The list below are some of his most cited publications <ref name=":1" />:
Line 45: Line 45:
* Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. <ref>Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. 10.1016/B978-0-12-398270-4.00021-5.https://www.researchgate.net/publication/282594766_Alzheimer_Disease</ref>
* Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. <ref>Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. 10.1016/B978-0-12-398270-4.00021-5.https://www.researchgate.net/publication/282594766_Alzheimer_Disease</ref>


*{{cite book|doi=10.1016/B978-0-12-374947-5.00045-6|chapter=Motor Neuron Diseases|title=Basic Neurochemistry|year=2012|last1=Wong|first1=Philip C.|last2=Chiang|first2=Po-Min|last3=Martin|first3=Lee J.|last4=Koliatsos|first4=Vassilis|last5=Price|first5=Donald L.|pages=801–814|isbn=9780123749475}}
*Wong, Philip & Chiang, Po-Min & Martin, Lee & Koliatsos, Vassilis & Price, Donald. (2012). Motor Neuron Diseases.<ref>Wong, Philip & Chiang, Po-Min & Martin, Lee & Koliatsos, Vassilis & Price, Donald. (2012). Motor Neuron Diseases. 10.1016/B978-0-12-374947-5.00045-6.https://www.researchgate.net/publication/285687008_Motor_Neuron_Diseases</ref>


*Tsao, William & Jeong, Yun & Lin, Sophie & Ling, Jonathan & Price, Donald & Chiang, Po-Min & Wong, Philip. (2012). Rodent models of TDP-43: Recent advances.<ref>Tsao, William & Jeong, Yun & Lin, Sophie & Ling, Jonathan & Price, Donald & Chiang, Po-Min & Wong, Philip. (2012). Rodent models of TDP-43: Recent advances. Brain research. 1462. 26-39. 10.1016/j.brainres.2012.04.031.https://www.researchgate.net/publication/225047518_Rodent_models_of_TDP-43_Recent_advances</ref>
*{{cite journal|doi=10.1016/j.brainres.2012.04.031|title=Rodent models of TDP-43: Recent advances|year=2012|last1=Tsao|first1=William|last2=Jeong|first2=Yun Ha|last3=Lin|first3=Sophie|last4=Ling|first4=Jonathan|last5=Price|first5=Donald L.|last6=Chiang|first6=Po-Min|last7=Wong|first7=Philip C.|journal=Brain Research|volume=1462|pages=26–39|pmid=22608070|pmc=3613131}}


*Li, Tong & Li, Yue-Ming & Ahn, Kwangwook & Price, Donald & Sisodia, Sangram & Wong, Philip. (2011). Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo.<ref>Li, Tong & Li, Yue-Ming & Ahn, Kwangwook & Price, Donald & Sisodia, Sangram & Wong, Philip. (2011). Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo. PloS one. 6. e28179. 10.1371/journal.pone.0028179.https://www.researchgate.net/publication/51852663_Increased_Expression_of_PS1_Is_Sufficient_to_Elevate_the_Level_and_Activity_of_g-Secretase_In_Vivo</ref>
*{{cite journal|doi=10.1371/journal.pone.0028179|title=Increased Expression of PS1 is Sufficient to Elevate the Level and Activity of γ-Secretase in Vivo|year=2011|last1=Li|first1=Tong|last2=Li|first2=Yue-Ming|last3=Ahn|first3=Kwangwook|last4=Price|first4=Donald L.|last5=Sisodia|first5=Sangram S.|last6=Wong|first6=Philip C.|journal=PLOS One|volume=6|issue=11|pages=e28179|pmid=22140537|bibcode=2011PLoSO...628179L}}


*Wu, Jing & Petralia, Ronald & Kurushima, Hideaki & Patel, Hiral & Jung, Mi-young & Volk, Lenora & Chowdhury, Shoaib & Shepherd, Jason & Dehoff, Marlin & Li, Yueming & Kuhl, Dietmar & Huganir, Richard & Price, Donald & Scannevin, Robert & Troncoso, Juan & Wong, Philip & Worley, Paul. (2011). Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation.<ref>Wu, Jing & Petralia, Ronald & Kurushima, Hideaki & Patel, Hiral & Jung, Mi-young & Volk, Lenora & Chowdhury, Shoaib & Shepherd, Jason & Dehoff, Marlin & Li, Yueming & Kuhl, Dietmar & Huganir, Richard & Price, Donald & Scannevin, Robert & Troncoso, Juan & Wong, Philip & Worley, Paul. (2011). Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation. Cell. 147. 615-28. 10.1016/j.cell.2011.09.036.https://www.researchgate.net/publication/51755924_ArcArg31_Regulates_an_Endosomal_Pathway_Essential_for_Activity-Dependent_b-Amyloid_Generation</ref>
*{{cite journal|doi=10.1016/j.cell.2011.09.036|title=Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation|year=2011|last1=Wu|first1=Jing|last2=Petralia|first2=Ronald S.|last3=Kurushima|first3=Hideaki|last4=Patel|first4=Hiral|last5=Jung|first5=Mi-Young|last6=Volk|first6=Lenora|last7=Chowdhury|first7=Shoaib|last8=Shepherd|first8=Jason D.|last9=Dehoff|first9=Marlin|last10=Li|first10=Yueming|last11=Kuhl|first11=Dietmar|last12=Huganir|first12=Richard L.|last13=Price|first13=Donald L.|last14=Scannevin|first14=Robert|last15=Troncoso|first15=Juan C.|last16=Wong|first16=Philip C.|last17=Worley|first17=Paul F.|journal=Cell|volume=147|issue=3|pages=615–628|pmid=22036569}}


*Pan, Bao & Hoffman, Paul & Ferraris, Dana & Tsukamoto, Takashi & Nguyen, Thien & Wong, Philip & Price, Donald & Slusher, Barbara & Griffin, John. (2011). Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System.<ref>Pan, Bao & Hoffman, Paul & Ferraris, Dana & Tsukamoto, Takashi & Nguyen, Thien & Wong, Philip & Price, Donald & Slusher, Barbara & Griffin, John. (2011). Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31. 5744-54. 10.1523/JNEUROSCI.6810-10.2011.https://www.researchgate.net/publication/51048644_Reduced_BACE1_Activity_Enhances_Clearance_of_Myelin_Debris_and_Regeneration_of_Axons_in_the_Injured_Peripheral_Nervous_System</ref>
*{{cite journal|doi=10.1523/JNEUROSCI.6810-10.2011|title=Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System|year=2011|last1=Farah|first1=M. H.|last2=Pan|first2=B. H.|last3=Hoffman|first3=P. N.|last4=Ferraris|first4=D.|last5=Tsukamoto|first5=T.|last6=Nguyen|first6=T.|last7=Wong|first7=P. C.|last8=Price|first8=D. L.|last9=Slusher|first9=B. S.|last10=Griffin|first10=J. W.|journal=Journal of Neuroscience|volume=31|issue=15|pages=5744–5754|pmid=21490216|pmc=3302726}}


*Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.. Proceedings of the National Academy of Sciences of the United States of America. 91. 8292-6. 10.1073/pnas.91.17.8292.<ref>Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.https://www.researchgate.net/publication/15140045_Superoxide_dismutase_1_with_mutations_linked_to_familial_amyotrophic_lateral_sclerosis_possesses_significant_activity</ref>
*Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.. Proceedings of the National Academy of Sciences of the United States of America. 91. 8292-6. 10.1073/pnas.91.17.8292.<ref>Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.https://www.researchgate.net/publication/15140045_Superoxide_dismutase_1_with_mutations_linked_to_familial_amyotrophic_lateral_sclerosis_possesses_significant_activity</ref>


⚫
== References ==

'''Donald L. Price'''
{| class="wikitable"
|-
| Born || 1935
|-
| Alma Mater || [[Wesleyan University]] (B.A.)
[[Albany Medical School of Union University]] (M.D.)
|-
| Institutions || [[Harvard Medical School]]
[[Johns Hopkins University School of Medicine]]
|-
| Known For || Research on Alzheimer's Disease
|-
| Field || [[Neuroscience]]
[[Neuropathology]]
|-
| Awards || Metropolitan Life Foundation Award (1989)
Potamkin Prize for Alzheimer's disease Research (1992)
Leadership in Alzheimer's disease (LEAD) Award (1994)
Wartenberg Award (2001)
The Award for Meritorious Contributions to Neuropathology (2012)
AAIC Lifetime Achievement Awards in Alzheimer's disease (2015)
2 Javits Neuroscience Investigator Merit Awards (N.D.)
|}

⚫
=== References ===
<references />
<references />

Revision as of 16:32, 31 March 2020

Donald L. Price (born c. 1935) is an American neuropathologist and professor at the Johns Hopkins School of Medicine. He was born in Stamford, Connecticut. He attended Wesleyan University, where he received a Bachelor’s of Arts in English Literature. In 1961, he graduated from Albany Medical College of Union University, where he received a Master’s Degree. He and his wife have three children, all of whom currently practice medicine.[1]

Career and research

Defects in the Brain due to Alzheimer's disease

After graduating from Albany Medical School of Union University, Price received a Postdoctoral Fellowship studying Cellular/Molecular Biology at Harvard University. He later became an assistant professor in the Departments of Neurology and Pathology at Harvard Medical School in 1970. A year later, he became an associate professor at Johns Hopkins University. In 1990, he served as the President of American Association of Neuropathologists[2]. From 2000-2001, he served as the President of the Society for Neuroscience[3].

In his early research years, Price focused on the biology of motor neurons, but later in his life, he expanded in his research interests and became more known for researching neurobiology and the mechanisms of the brain. Throughout his life, Price explored different experiments and studies, mainly including the study of animal models in order to “allow a more direct insight into pathogenesis” rather than using human models. Dr. Price’s research interests involve “age-associated neurodegenerative diseases, particularly [Alzheimer’s Disease]”[4]. He has received support from numerous foundations on his research for Alzheimer’s disease. In 1985, he became the Principal Investigator of the Alzheimer’s Disease Research Center.

Further, Price’s research has a focus on treatment for neurodegenerative conditions. His work with transgenic mice seeks to experimentally test new treatment mechanisms before they reach human subjects[5]. These studies have identified specific genes that are often risk factors, particularly amyloid-prone genes, and attempted to correlate them to particular behaviors associated with Alzheimer’s Disease. For example, his research has concluded that mutations to amyloid precursor proteins are linked to memory loss. Studies like these ultimately aim to identify new targets for treatment of the disease.

Price took part in the publication of the Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology text [6]. Within the text, he worked with colleagues such as Philip C. Wong and Tong Li to write a chapter that focuses on Alzheimer’s disease and how it leads to major defects within the brain. Alzheimer’s disease (AD) is one of Price’s most researched topics. The disease causes people to have progressive memory loss and also problems with cognitive development. The neuroscience behind AD is characterized by neuronal loss, which means the failure of functioning neurons, or the lack of neurofibrillary tangles within parts of the brain. The neurofibrillary tangles (NFTs) were most commonly found in the central superior nucleus and they help determine the duration of the disease. Patients who had a longer duration of AD had less NFTs than patients who had a shorter duration of AD. The number of NFTs in the nuclei reflect on how the rate of progression, so if a small number of NFTs are found, then they have a greater chance of becoming better. This disease affects the person’s everyday life due to the decline in cognitive abilities and memory loss. In cases of AD, there are various kinds of techniques used to detect any impairments or defects within the brain. One of the techniques used is a functional magnetic resonance imaging (fMRI) which are most likely used to detect any evidence of atrophy with relation to the hippocampus and entorhinal cortex. Another technique is called positron emission tomography (PET) and is used to look within the parietal and temporal lobes to detect any decreased glucose or blood flow. Alzheimer’s Disease, overall, has many symptoms that involve abnormalities within different parts of the brain that are important for memory storage and cognitive development. Price expands his interest and knowledge towards this neurodegenerative disease in most of his research.

He has mentored several prominent physicians and investigators at the Johns Hopkins University’s Neuropathology Division to become important leaders in the field of neurobiology of diseases. Some notable physicians and investigators include Carlos Porteria-Cailliau, Naomi E. Rance, Charles White III, David R. Borchet, and Lee J. Martin[7].

Awards and honors

Year Award/Honor
1989 Metropolitan Life Foundation Award[8]
1990 President of the American Association of Neuropathologists
1992 Potamkin Prize for Alzheimer’s Disease Research
1994 Leadership in Alzheimer’s Disease (LEAD) Award (National Institute of Aging)
2000-2001 President of the Society for Neuroscience
2001 Wartenberg Award[9]
2012 The Award for Meritorious Contributions to Neuropathology[4]
2015 AAIC Lifetime Achievement Awards in Alzheimer’s Disease[10]
N.D. 2 Javits Neuroscience Investigator Merit Awards (National Institute of Neurological Disorders and Stroke)[1]

Publications

Price was placed in the top ten authors of high impact papers in Neuroscience from 1990-200 due to writing over 500 publications and over 200 book chapters. The list below are some of his most cited publications [4]:

  • Troncoso, Juan & Crain, Barbara & Sisodia, Sangram & Price, Donald. (2019). Pathology, Neurobiology, and Animal Models of Alzheimer’s Disease.[11]
  • Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. [12]
  • Wong, Philip C.; Chiang, Po-Min; Martin, Lee J.; Koliatsos, Vassilis; Price, Donald L. (2012). "Motor Neuron Diseases". Basic Neurochemistry. pp. 801–814. doi:10.1016/B978-0-12-374947-5.00045-6. ISBN 9780123749475.
  • Wu, Jing; Petralia, Ronald S.; Kurushima, Hideaki; Patel, Hiral; Jung, Mi-Young; Volk, Lenora; Chowdhury, Shoaib; Shepherd, Jason D.; Dehoff, Marlin; Li, Yueming; Kuhl, Dietmar; Huganir, Richard L.; Price, Donald L.; Scannevin, Robert; Troncoso, Juan C.; Wong, Philip C.; Worley, Paul F. (2011). "Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation". Cell. 147 (3): 615–628. doi:10.1016/j.cell.2011.09.036. PMID 22036569. {{cite journal}}: no-break space character in |first12= at position 8 (help); no-break space character in |first13= at position 7 (help); no-break space character in |first15= at position 5 (help); no-break space character in |first16= at position 7 (help); no-break space character in |first17= at position 5 (help); no-break space character in |first2= at position 7 (help); no-break space character in |first8= at position 6 (help)
  • Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.. Proceedings of the National Academy of Sciences of the United States of America. 91. 8292-6. 10.1073/pnas.91.17.8292.[13]

References

  1. ^ a b "The Donald L. Price Research Fund" (PDF). John Hopkins Medicine. May 18, 2008.{{cite web}}: CS1 maint: url-status (link)
  2. ^ "Past Presidents and Officers". www.neuropath.org. Retrieved 2020-03-30.
  3. ^ "SfN Presidents". www.sfn.org. Retrieved 2020-03-30.
  4. ^ a b c Troncoso, Juan (2012-11-01). "Meritorious Contributions to Neuropathology". Journal of Neuropathology & Experimental Neurology. 71 (11): 1030–1031. doi:10.1097/NEN.0b013e318273643e. ISSN 0022-3069.
  5. ^ Price, D. L.; Tanzi, R. E.; Borchelt, D. R.; Sisodia, S. S. (1998). "Alzheimer's disease: genetic studies and transgenic models". Annual Review of Genetics. 32: 461–493. doi:10.1146/annurev.genet.32.1.461. ISSN 0066-4197. PMID 9928488.
  6. ^ Wong, Philip & Li, Tong & Price, Donald. (2012). Neurobiology of Alzheimer's Disease. Basic Neurochemistry. 781-790. 10.1016/B978-0-12-374947-5.00046-8.
  7. ^ "Neurotree - Donald L. Price Family Tree". neurotree.org. Retrieved 2020-03-30.
  8. ^ "Winners | MetLife Foundation Awards in Medical Research". mlfawards.afar.org. Retrieved 2020-03-30.
  9. ^ "Plenary History". www.aan.com. Retrieved 2020-03-30.
  10. ^ "AAIC 2019 - Awards". AAIC. 2016-03-18. Retrieved 2020-03-30.
  11. ^ Troncoso, Juan & Crain, Barbara & Sisodia, Sangram & Price, Donald. (2019). Pathology, Neurobiology, and Animal Models of Alzheimer’s Disease. 10.1201/9780429260353-17.https://www.researchgate.net/publication/334079755_Pathology_Neurobiology_and_Animal_Models_of_Alzheimer's_Disease
  12. ^ Savonenko, Alena & Melnikova, Tatiana & Li, Tong & Price, Donald & Wong, Philip. (2015). Alzheimer Disease. 10.1016/B978-0-12-398270-4.00021-5.https://www.researchgate.net/publication/282594766_Alzheimer_Disease
  13. ^ Borchelt, David & Lee, M & Slunt, H & Guarnieri, Michael & xu, Zuoshang & Wong, P & Brown, R.H. & Price, D. & Sisodia, S & Cleveland, Don. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.https://www.researchgate.net/publication/15140045_Superoxide_dismutase_1_with_mutations_linked_to_familial_amyotrophic_lateral_sclerosis_possesses_significant_activity
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