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→‎Transmission of Electrical Currents: Include Transcranial magnetic stimulation section
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There are three methods by which electrical currents are transmitted through the brain: deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS)<ref>{{Cite journal|last=Cabrera|first=Laura Y.|last2=Evans|first2=Emily L.|last3=Hamilton|first3=Roy H.|date=January 2014|title=Ethics of the electrified mind: defining issues and perspectives on the principled use of brain stimulation in medical research and clinical care|url=https://www.ncbi.nlm.nih.gov/pubmed/23733209|journal=Brain Topography|volume=27|issue=1|pages=33–45|doi=10.1007/s10548-013-0296-8|issn=1573-6792|pmc=3806889|pmid=23733209|via=}}</ref>.
There are three methods by which electrical currents are transmitted through the brain: deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS)<ref>{{Cite journal|last=Cabrera|first=Laura Y.|last2=Evans|first2=Emily L.|last3=Hamilton|first3=Roy H.|date=January 2014|title=Ethics of the electrified mind: defining issues and perspectives on the principled use of brain stimulation in medical research and clinical care|url=https://www.ncbi.nlm.nih.gov/pubmed/23733209|journal=Brain Topography|volume=27|issue=1|pages=33–45|doi=10.1007/s10548-013-0296-8|issn=1573-6792|pmc=3806889|pmid=23733209|via=}}</ref>.


==== Deep brain stimulation (DBS) ====
==== Deep Brain Stimulation (DBS) ====
DBS involves implanting an electrical device, or neurostimulator, into the brain<ref>{{Cite journal|last=Kringelbach|first=Morten L.|last2=Jenkinson|first2=Ned|last3=Owen|first3=Sarah L. F.|last4=Aziz|first4=Tipu Z.|date=August 2007|title=Translational principles of deep brain stimulation|url=https://www.nature.com/articles/nrn2196|journal=Nature Reviews Neuroscience|language=en|volume=8|issue=8|pages=623–635|doi=10.1038/nrn2196|issn=1471-0048|via=}}</ref>. The neurostimulator is a thin wire with electrodes at its tip. Low levels of electric current are transmitted through the brain. The location where the electrodes are implanted depends on the neurological disorder being treated<ref>{{Cite web|url=https://www.nm.org/healthbeat/medical-advances/how-does-deep-brain-stimulation-work|title=How Does Deep Brain Stimulation Work?|last=Medicine|first=Northwestern|website=Northwestern Medicine|language=en-US|access-date=2020-04-03}}</ref>. The company Neuralink hopes that their DBS device will include “as many as 3072 electrodes distributed along 96 threads”, and that the procedure to implant the threads would be as non-invasive as LASIK eye suregery<ref>{{Cite journal|last=Musk|first=Elon|last2=Neuralink|date=2019-08-02|title=An integrated brain-machine interface platform with thousands of channels|url=https://www.biorxiv.org/content/10.1101/703801v4|journal=bioRxiv|language=en|pages=703801|doi=10.1101/703801}}</ref><ref>{{Cite web|url=https://www.theverge.com/2019/7/16/20697123/elon-musk-neuralink-brain-reading-thread-robot|title=Elon Musk unveils Neuralink’s plans for brain-reading ‘threads’ and a robot to insert them|last=Lopatto|first=Elizabeth|date=2019-07-16|website=The Verge|language=en|access-date=2020-04-03}}</ref>.
DBS involves implanting an electrical device, or neurostimulator, into the brain<ref>{{Cite journal|last=Kringelbach|first=Morten L.|last2=Jenkinson|first2=Ned|last3=Owen|first3=Sarah L. F.|last4=Aziz|first4=Tipu Z.|date=August 2007|title=Translational principles of deep brain stimulation|url=https://www.nature.com/articles/nrn2196|journal=Nature Reviews Neuroscience|language=en|volume=8|issue=8|pages=623–635|doi=10.1038/nrn2196|issn=1471-0048|via=}}</ref>. The neurostimulator is a thin wire with electrodes at its tip. Low levels of electric current are transmitted through the brain. The location where the electrodes are implanted depends on the neurological disorder being treated<ref>{{Cite web|url=https://www.nm.org/healthbeat/medical-advances/how-does-deep-brain-stimulation-work|title=How Does Deep Brain Stimulation Work?|last=Medicine|first=Northwestern|website=Northwestern Medicine|language=en-US|access-date=2020-04-03}}</ref>. The company Neuralink hopes that their DBS device will include “as many as 3072 electrodes distributed along 96 threads”, and that the procedure to implant the threads would be as non-invasive as LASIK eye suregery<ref>{{Cite journal|last=Musk|first=Elon|last2=Neuralink|date=2019-08-02|title=An integrated brain-machine interface platform with thousands of channels|url=https://www.biorxiv.org/content/10.1101/703801v4|journal=bioRxiv|language=en|pages=703801|doi=10.1101/703801}}</ref><ref>{{Cite web|url=https://www.theverge.com/2019/7/16/20697123/elon-musk-neuralink-brain-reading-thread-robot|title=Elon Musk unveils Neuralink’s plans for brain-reading ‘threads’ and a robot to insert them|last=Lopatto|first=Elizabeth|date=2019-07-16|website=The Verge|language=en|access-date=2020-04-03}}</ref>.

==== Transcranial Magnetic Stimulation (TMS) ====
TMS sends short bursts of magnetic energy to the left frontal cortex through a small electromagnetic coil<ref>{{Cite web|url=http://www.butler.org/butler-ri/programs/outpatient/how-does-tms-work.cfm|title=Transcranial Magnetic Stimulation (TMS) {{!}} How Does TMS Work|website=www.butler.org|access-date=2020-04-03}}</ref>. Some studies have found that TMS improves cognition and motor performance<ref>{{Cite journal|last=Levasseur-Moreau|first=Jean|last2=Brunelin|first2=Jerome|last3=Fecteau|first3=Shirley|date=2013-08-14|title=Non-invasive brain stimulation can induce paradoxical facilitation. Are these neuroenhancements transferable and meaningful to security services?|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743213/|journal=Frontiers in Human Neuroscience|volume=7|doi=10.3389/fnhum.2013.00449|issn=1662-5161|pmc=3743213|pmid=23966923}}</ref>. Other studies have investigated the relation between TMS and its ability to recover lost memories<ref>{{Cite journal|last=Rose|first=Nathan S.|last2=LaRocque|first2=Joshua J.|last3=Riggall|first3=Adam C.|last4=Gosseries|first4=Olivia|last5=Starrett|first5=Michael J.|last6=Meyering|first6=Emma E.|last7=Postle|first7=Bradley R.|date=2016-12-02|title=Reactivation of latent working memories with transcranial magnetic stimulation|url=https://science.sciencemag.org/content/354/6316/1136|journal=Science|language=en|volume=354|issue=6316|pages=1136–1139|doi=10.1126/science.aah7011|issn=0036-8075|pmid=27934762}}</ref>.


==Applications ==
==Applications ==

Revision as of 19:23, 3 April 2020


Neurohacking is a subclass of biohacking, focused specifically on the brain. Neurohackers seek to better themselves or others by “hacking the brain” to improve reflexes, learn faster, or to treat psychological disorders[1]. The modern neurohacking movement has been around since the 1980s. However, herbal supplements have been used to increase brain function for hundreds of years. After a brief period marked by a lack of research in the area, neurohacking started regaining interest in the early 2000s[2][3]. Currently, most neurohacking is performed via do-it-yourself (DIY) methods by in-home users[1].

Simple uses of neurohacking include the use of chemical supplements to increase brain function[4]. More complex medical devices can be implanted to treat psychological disorders and illnesses[5].

History

Anna Wexler, a member of the Department of Science at Massachusetts Institute of Technology, claims that neurohacking should be viewed as a subdivision of the ‘life hacking’ movement [1]. She argues that popularized scientific publications have led to a greater public awareness of neuroscience since the turn of the century[6]. As a result, the public was made aware of the brain’s plasticity and its potential to improve[6].

The use of mind-altering substances derived from plants dates back to ancient history[7].  Neurohackers use a class of chemical substances that improve higher order brain functions called nootropics. The term nootropics was first proposed in 1972 by Corneliu Giurgea, a Romanian chemist from University of Bucharest[8].

In his study, he classified Piracetam as a nootropic and determined that nootropics should fit the following criteria:

  • Enhance learning
  • Resist impairing agents
  • Augment informational transfer between the two hemisphere of the brain
  • Heighten the brain’s resistance against various forms of “aggressions”
  • Improved “tonic, cortico-subcortical ‘control’”
  • Lack of pharmacological effects of other common psychoactive drugs[8].

Today, various nootropics are available via prescription and over the counter[9].

The 2000 study by Michael A. Nitsche and Walter Paulus at the University of Goettingen is considered to be the one of the first device-oriented attempts at influencing the brain non-invasively. The study found that the motor cortex of the brain responds to weak electrical stimuli in the form of transcranial direct current stimulation (tDCS)[10][11]. A later study in 2003 by Branislav Savic and Beat Meier found that (tDCS) improves motor sequence learning[12]. More recent studies have concluded that tDCS may alleviate neuropathic pain, depression, schizophrenia, and other neurological disorders[11]. Methods of non-invasive brain stimulation (NIBS) have been found to enhance human performance. In 2019, a study funded by the US Department of Defense found that cognition and motor performance could be improved by tDCS. This investigation showed that tDCS could be used to enhance the abilities of military personnel. However, side effects such as “itching, tingling, and headaches” were noted[13]. The study concluded that more research into adequate safety regulations is needed before it can be properly implemented[13].

A resurgence in the popularity of at-home and DIY neurohacking started in 2011[1][14]. The recent availability of brain stimulation devices contributed to the rise in the home neurohacking movement[1]. Individuals applied weak electrical currents to their brain in hopes of improving performance and productivity[14]. Since 2017, neurohacking devices have been available to the general public for unsupervised use. However, these methods of neurohacking have yet to gain widespread acceptance from the general public, and user retention rate for the devices remains low[1][11].

In 2018, Marom Bikson and his colleagues at the City college of New York released a report to aid consumers in making an informed choice regarding the purchase of tDCS devices[11]. In particular, Bikson stated that the report hoped to educate consumers on the reasons why a significant price differentiation existed across the various devices on the market.

Technology

There are three main categories of neurohacking methods: oral supplements or ingestibles, procedural training exercises, and the transmission of electrical currents through the brain.

Oral Supplements and Ingestibles

Nootropics are any chemical compounds that cause an improvement in brain function[15]. Although many are naturally produced by the body, ingestible supplements are often required to artificially raise the concentration of these compounds in the bloodstream to produce a significant effect. Nootropics can be further classified into two categories: synthetics nootropics and natural nootropics[2].

Synthetic Nootropics

Synthetic nootropics refer to any lab-produced nootropics, including Piracetam[16]. Synthetic nootropics can act at three different junctions[2]:

  1. Dopamine receptors
  2. Adrenergic receptors
  3. Acetylcholine and glutamate receptors[2]

Natural Nootropics

Natural, or herbal, nootropics, include food-based antioxidants and vitamin supplements[2]. There are three main mechanisms by which natural nootropics affect brain activity[2]:

  1. Neurotransmitter modulation
  2. Modulation of signal transduction
  3. Vasodilation

Popular supplements such as Ginkgo biloba and Panax quinquefolius (American Ginseng) are characterized as natural and herbal nootropics[16]. Few studies have been conducted regarding the safety and long-term effects of prescribing these herbal supplements as a means of mitigating age-related cognitive decline. However, current research has indicated that these methods have the potential to alleviate the mental deterioration in older individuals[2].

Procedural Training Exercises

Procedural training methods strengthen the connections between neurons. For example, brain training games have been around since the 2000s. Companies such as PositScience, Lumosity, and CogniFit created video games designed to improve the user’s brain function[1]. These brain-training games improve neural capacity by adding game-like features to comprehension skills[17].

Transmission of Electrical Currents

There are three methods by which electrical currents are transmitted through the brain: deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS)[18].

Deep Brain Stimulation (DBS)

DBS involves implanting an electrical device, or neurostimulator, into the brain[19]. The neurostimulator is a thin wire with electrodes at its tip. Low levels of electric current are transmitted through the brain. The location where the electrodes are implanted depends on the neurological disorder being treated[20]. The company Neuralink hopes that their DBS device will include “as many as 3072 electrodes distributed along 96 threads”, and that the procedure to implant the threads would be as non-invasive as LASIK eye suregery[21][22].

Transcranial Magnetic Stimulation (TMS)

TMS sends short bursts of magnetic energy to the left frontal cortex through a small electromagnetic coil[23]. Some studies have found that TMS improves cognition and motor performance[24]. Other studies have investigated the relation between TMS and its ability to recover lost memories[25].

Applications

Many applications of neurohacking center around improving quality of life[1].

Mental Health

Bettering people’s mental health is one primary application of neurohacking.

Virtual reality exposure therapy is one application of neurohacking, and is being used to treat post traumatic stress. The USC Institute for Creative Technologies has been working on exposure therapy techniques since 2005, and exposure therapy is now an evidence based treatment for post traumatic stress[26].

Exposure therapy retrains the mind of the patient to reduce the fear associated with feeling a certain way or experiencing certain triggering stimuli[27]. By confronting situations in a safe and controlled virtual reality environment, the patient is able to reduce the anxiety associated with those circumstances.

The FDA has approved DBS devices for the treatment of both Parkinson’s Disease and Dystonia[5]. There are several risks involved with this treatment, such as depression, hypo-mania, euphoria, mirth, and hypersexuality. However, permanent complications are rare[28]. DBS has also been used to Tourette Syndrome[5], dyskinesia[29] eppilepsy[30] and depression[31], although more research is needed in these areas before it can be deemed safe.

Human Enhancement

Enhancing the human experience is another application of neurohacking. Methods include simple brain-training games, chemical enhancers, and electrical brain stimulation.

Caffeine is an effective method for enhancing human performance in everyday life. Caffeine is the most popular drug in the world (humans drink a collective 1.6 billion cups per day) and is also the most popular method by which people are neurohacking[32]. Caffeine improves memory, sociability, and alertness[33].

Another chemical performance enhancer, dihexa, is an ingestable neuropeptide that was approved for use in the United States in 2019. It is prescribed to clients who want to achieve a specific goal such as learn a new language or master an instrument[4].

Information Retrieval

The third primary application of neurohacking is information retrieval from the brain. This typically involves the use of a brain-machine interface (BMI) – an apparatus to measure electrical signals in the brain[34].

In 2016, researchers modeled an individual’s interest in digital content by monitoring their EEG (electroencephalogram). The researchers asked the user to read Wikipedia articles. From data in the EEG, they could predict which article the user would want to read next based on the individual’s expressed interest in each topic. The researchers claim this paradigm can be used to “recommend information without any explicit user interaction”[35].

In July 2019, Neuralink – a company developing implantable brain-machine interfaces – presented their research on their high bandwidth BMI. Neuralink claims to have developed an implantable BMI device that is capable of recording and delivering full bandwidth data from the brain. The company hopes to use this technology to create a high-speed connection between the brain and digital technology, bypassing the need to type search queries or read the results[36].

See also

References

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External links


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