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Princess Izevbua Imoukhuede | |
|---|---|
| Born | 1980 (age 43–44) |
| Alma mater | Massachusetts Institute of Technology California Institute of Technology |
| Scientific career | |
| Institutions | Washington University in St. Louis Johns Hopkins University University of Illinois at Urbana–Champaign |
| Thesis | Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1 (2008) |
| Website | Imoukhuede Laboratory |
Princess Imoukhuede (born 1980) is an American chemical engineer and Associate Professor at the Washington University in St. Louis. She was awarded the 2018 Illinois Mathematics and Science Academy Distinguished Leadership Award and the 2018 Nano Research Young Innovators Award in Nanobiotechnology.
Early life and education
Imoukhuede grew up in Matteson, Illinois.[1] She was involved with track and field as a child, and competed in shot put from the age of eight. By the time she was in eighth grade she had become interested in science, and her parents gave her a chemistry set to play with at home.[2] Imoukhuede was supported by her parents to attend the Illinois Mathematics and Science Academy.[2] Imoukhuede was an undergraduate student in biomedical engineering at Massachusetts Institute of Technology (MIT). Here she performed undergraduate research under the supervision of Robert S. Langer on the incorporation of adenoviruses in a liposome-based gene therapy system. In her freshman year she was honoured at the Eastern College Athletic Conference, and was the first woman from MIT to qualify for the National Collegiate Athletic Association. Whilst at MIT Imoukhuede took part in athletics, serving as captain of the varsity track and field team. Imoukhuede was described by Roger Crosley, then MIT Director of Sport, as “the best weight thrower we ever had in track and field,”. After earning her bachelor's degree, Imoukhuede moved to the California Institute of Technology, where she worked alongside Henry Lester on the structure of the GABA transporter and Förster resonance energy transfer.[3]
Research and career
She was a postdoctoral scholar at Johns Hopkins University, where she specialised in biomedical engineering in the laboratory of Aleksander Popel.[2] It was here she started working on the vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in ischemia and cancer. After completing her postdoctoral research, Imoukhuede joined the University of Illinois at Urbana–Champaign.
Imoukhuede studies the mechanisms that regulate angiogenic signalling, including tyrosine kinase receptors, VEGF receptors and platelet-derived growth factor receptors. In 2019 Imoukhuede and Sarah K. England partnered to improve the efficacy and safety of oxytocin during labour.[4] Imoukhuede is developing a computational model that could be used to predict the function of oxytocin receptor function.[4]
Awards and honours
- 2017 National Science Foundation CAREER Award[5]
- 2018 Nano Research Young Innovators Award in Nanobiotechnology
- 2018 Illinois Mathematics and Science Academy Distinguished Leadership Award
- 2019 American Institute of Chemical Engineers Futures Researcher[6]
Select publications
- Drenan, Ryan M.; Nashmi, Raad; Imoukhuede, Princess; Just, Herwig; McKinney, Sheri; Lester, Henry A. (2008-01-01). "Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits". Molecular Pharmacology. 73 (1): 27–41. doi:10.1124/mol.107.039180. ISSN 0026-895X. PMID 17932221.
- Imoukhuede, P.I.; Popel, Aleksander S. (2011). "Quantification and cell-to-cell variation of vascular endothelial growth factor receptors". Experimental Cell Research. 317 (7): 955–965. doi:10.1016/j.yexcr.2010.12.014. ISSN 0014-4827.
- Finley, Stacey D; Engel-Stefanini, Marianne O; Imoukhuede, PI; Popel, Aleksander S (2011). "Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies". BMC Systems Biology. 5 (1): 193. doi:10.1186/1752-0509-5-193. ISSN 1752-0509.
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References
- ^ "Princess Imoukhuede". MIT Spectrum. Retrieved 2020-10-21.
- ^ a b c "410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation". People Behind the Science Podcast. 2017-08-14. Retrieved 2020-10-21.
- ^ Imoukhuede, Princess Izevbua (2008). Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1 (Thesis). Pasadena, Calif.: California Institute of Technology.
- ^ a b "Imoukhuede teams with England on $2.4M NIH grant". engineering.wustl.edu. Retrieved 2020-10-21.
- ^ "NSF Award Search: Award#1653925 - CAREER: qBio+cBio=sBio; Identifying the role of cross-family signaling in angiogenesis". www.nsf.gov. Retrieved 2020-10-21.
- ^ Napier, Douglas H. (1992-08). "Workbook of test cases for vapor cloud source dispersion models, By Steven R. Hanna and David Strimaitis for the Centre for Chemical Process Safety of the American Institute of Chemical Engineers 1989, 122 + xv pages, American Institute of chemical Engineers, New York. Isbn 0-8169-0455-3, g-5. price: U.s. $60 ($30 to members of aiche)". The Canadian Journal of Chemical Engineering. 70 (4): 831–831. doi:10.1002/cjce.5450700433. ISSN 0008-4034.
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