Texas Tech scored first on a 29-yard field goal from Robert Treece, giving Tech a 3–0 lead. Kliff Kingsbury threw a 46-yard touchdown pass to Nehemiah Glover making it 10–0. He threw another 19-yard touchdown pass to Mickey Peters to make the score at the end of the 1st quarter, Texas Tech, 17, Clemson, 0.
In the second quarter, Taurean Henderson scored from 10 yards out, and Tech took a 24–0 lead. After Clemson forced a safety, Wes Welker scored on a 59-yard punt return to make it 31–2, Texas Tech. Robert Treece's 34-yard field goal before halftime made it 34–2 Texas Tech.
In the third quarter, Charlie Whitehurst threw a 10-yard touchdown pass to Ben Hall to make it 34–9. B.J. Symons threw a 2-yard touchdown pass to Carlos Francis to make it 41–9, Texas Tech.
In the fourth quarter, Clemson's Chad Jasmine scored on a 2-yard touchdown run making it 41–15. Kliff Kingsbury threw a 9-yard touchdown pass to Wes Welker making it 48–15. A 26-yard touchdown pass from B.J. Symons to Taurean Henderson made the final score, Texas Tech 55, Clemson, 15.