3-Methoxy-4-hydroxyphenylglycol

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3-Methoxy-4-hydroxyphenylglycol
3-Methoxy-4-hydroxyphenylglycol.svg
Names
IUPAC name
1-(4-Hydroxy-3-methoxyphenyl) ethane-1,2-diol
Other names
MHPG
Identifiers
67423-45-4 N
ChemSpider 10348 YesY
Jmol-3D images Image
Image
KEGG C05594 YesY
MeSH Methoxyhydroxyphenylglycol
PubChem 10805
Properties
C9H12O4
Molar mass 184.18918
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation. In the brain, it is the principal norepinephrine metabolite. It is released into the blood and cerebrospinal fluid,[1] and a blood sample of it may therefore be an indication of recent sympathetic nervous system activity.

Low levels of it in the blood and CSF are connected to Anorexia nervosa.

Norepinephrine degradation. 3-Methoxy-4-hydroxyphenylglycol is shown at right. Enzymes are shown in boxes.[2]

References[edit]

  1. ^ Increase in cerebrospinal fluid and plasma levels of 3-methoxy-4- hydroxyphenylglycol in acute stroke T Kanda, K Azuma, F Sakai and Y Tazaki. Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Japan.
  2. ^ Figure 11-4 in: Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5.