AP1G2

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Adaptor-related protein complex 1, gamma 2 subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AP1G2 ; G2AD
External IDs OMIM603534 MGI1328307 HomoloGene49141 GeneCards: AP1G2 Gene
Orthologs
Species Human Mouse
Entrez 8906 11766
Ensembl ENSG00000213983 ENSMUSG00000040701
UniProt O75843 O88512
RefSeq (mRNA) NM_001282474 NM_007455
RefSeq (protein) NP_001269403 NP_031481
Location (UCSC) Chr 14:
24.03 – 24.04 Mb
Chr 14:
55.1 – 55.11 Mb
PubMed search [1] [2]

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.[1][2][3]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.[3]

Interactions[edit]

AP1G2 has been shown to interact with NEDD4.[4]

References[edit]

  1. ^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768. 
  2. ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett 435 (2-3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922. 
  3. ^ a b "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". 
  4. ^ Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. (United States) 283 (46): 32119–30. doi:10.1074/jbc.M802632200. ISSN 0021-9258. PMID 18772139. 

Further reading[edit]