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Rho/Rac guanine nucleotide exchange factor (GEF) 2
Symbols ARHGEF2 ; GEF; GEF-H1; GEFH1; LFP40; P40
External IDs OMIM607560 MGI103264 HomoloGene3468 GeneCards: ARHGEF2 Gene
RNA expression pattern
PBB GE ARHGEF2 207629 s at tn.png
PBB GE ARHGEF2 209435 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9181 16800
Ensembl ENSG00000116584 ENSMUSG00000028059
UniProt Q92974 Q60875
RefSeq (mRNA) NM_001162383 NM_001198911
RefSeq (protein) NP_001155855 NP_001185840
Location (UCSC) Chr 1:
155.92 – 155.98 Mb
Chr 3:
88.61 – 88.65 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.[1][2][3]


Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.[3]


ARHGEF2 has been shown to interact with PAK1.[4]


  1. ^ Ren Y, Li R, Zheng Y, Busch H (Feb 1999). "Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases". J Biol Chem 273 (52): 34954–60. doi:10.1074/jbc.273.52.34954. PMID 9857026. 
  2. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H et al. (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  3. ^ a b "Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2". 
  4. ^ Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM (Apr 2004). "p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor". J. Biol. Chem. 279 (18): 18392–400. doi:10.1074/jbc.M400084200. PMID 14970201. 

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