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Actin related protein 2/3 complex, subunit 1B, 41kDa
Protein ARPC1B PDB 1k8k.png
PDB rendering based on 1k8k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARPC1B ; ARC41; p40-ARC; p41-ARC
External IDs OMIM604223 MGI1343142 HomoloGene4179 GeneCards: ARPC1B Gene
Species Human Mouse
Entrez 10095 11867
Ensembl ENSG00000130429 ENSMUSG00000029622
UniProt O15143 Q9WV32
RefSeq (mRNA) NM_005720 NM_023142
RefSeq (protein) NP_005711 NP_075631
Location (UCSC) Chr 7:
98.97 – 98.99 Mb
Chr 5:
145.11 – 145.13 Mb
PubMed search [1] [2]

Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene.[1][2][3]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.[3]


ARPC1B has been shown to interact with PAK1.[4]


  1. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079. 
  2. ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (Jan 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem J 328 (1): 105–12. PMC 1218893. PMID 9359840. 
  3. ^ a b "Entrez Gene: ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa". 
  4. ^ Vadlamudi, Ratna K; Li Feng, Barnes Christopher J, Bagheri-Yarmand Rozita, Kumar Rakesh (Feb 2004). "p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate". EMBO Rep. (England) 5 (2): 154–60. doi:10.1038/sj.embor.7400079. ISSN 1469-221X. PMC 1298990. PMID 14749719. 

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