Ankle replacement, or ankle arthroplasty, is a surgical procedure to replace the damaged articular surfaces of the human ankle joint with prosthetic components. This procedure is becoming the treatment of choice for patients, replacing the conventional use of arthrodesis, i.e. fusion of the bones. The restoration of range of motion is the key feature in favor of ankle replacement with respect to arthrodesis. However, clinical evidence of the superiority of the former has only been demonstrated for particular isolated implant designs. 
Since the early 1970s, the disadvantages of ankle arthrodesis and the excellent results attained by arthroplasty at other human joints have encouraged numerous prosthesis designs also for the ankle. In the following decade, the disappointing results of long-term follow-up clinical studies  of the pioneering designs has left ankle arthrodesis as the surgical treatment of choice for these patients. More modern designs have produced better results, contributing to a renewed interest in total ankle arthroplasty over the past decade.
Nearly all designs from pioneers featured two-components; these designs have been categorized as incongruent and congruent, according to the shape of the two articular surfaces. After the early unsatisfactory results of the two-component designs, most of the more recent designs feature three-components, with a polyethylene meniscal bearing interposed between the two metal bone-anchored components. This meniscal bearing should allow full congruence at the articular surfaces in all joint positions in order to minimize wear and deformation of the components. Poor understanding of the functions of the structures guiding ankle motion in the natural joint (ligaments and articular surfaces), and poor restoration of these functions in the replaced joint may be responsible for the complications and revisions. 
- to replicate original joint function, by restoring an appropriate kinematics at the replaced joint;
- to permit a good fixation of the components, which would involve an appropriate load transfer to the bone and minimum risk of loosening;
- to guarantee longevity of the implant, which is mainly related to wear resistance;
- feasibility of implantation, because of the small dimensions of the joint.
As with other joint replacements, the traditional dilemma between mobility and congruency must be addressed. Unconstrained or semiconstrained designs allow the necessary mobility but require incongruent contact, thereby giving rise to large contact stresses and potentially high wear rates. Conversely, congruent designs produce large contact areas with low contact stresses but transmit undesirable constraint forces that can overload the fixation system at the bone-component interface.
The indications for the operation in general are as follow:
- patients with primary or posttraumatic osteoarthritis with relatively low functional demand;
- patients with severe ankle rheumatoid arthritis but not severe osteoporosis of the ankle;
- patients suitable for arthrodesis but rejecting it.
The general contraindications are:
- varus or valgus deformity greater than 15 degrees, severe bony erosion, severe talus subluxation;
- substantial osteoporosis or osteonecrosis particularly affecting the talus;
- previous or current infections of the foot;
- vascular disease or severe neurologic disorders;
- previous arthrodesis of the ipsilateral hip or knee or severe deformities of these joints.
Other potential contraindications such as capsuloligamentous instability and hindfoot or forefoot deformities affecting correct posture, are not considered relevant if resolved before or during this surgery.
The outcome of an ankle replacement includes factors like ankle function, pain, revision and implant survival. Outcome studies on modern designs show a five-year implant survival rate between 67% and 94%. and ten-year survival rates around 75%. Mobile bearing designs have enabled implant survival rates to continue to improve, reaching as high as 95% for five years and 90% for ten years.
Clinical ankle scores, such as the American Orthopaedcic Foot and Ankle Society (AOFAS) is an outcome rating system for ankle replacements. It is composed of the parameters pain (max 40 points), function (max 50 points) and alignment (max 10 points). Further outcome instruments include radiographic assessment of component stability and migration, and the assessment of its functionality in daily life using gait analysis or videofluoroscopy; the latter is a tool for three-dimensional measuring of the position and orientation of implanted prosthetic components at the replaced joints.
- Saltzman, C.L.; Mann, R.A.; Ahrens, J.E.; Amendola, A.; Anderson, R.B.; Berlet, G.C.; Brodky, J.W.; Chou, L.B.; Clanton, T.O.; Deland, J.T.; Deorio, J.K.; Horton, G.A.; Lee, T.H.; Mann, J.A.; Nunley, J.A.; Thordarson, D.B.; Walling, A.K.; Wapner, K.L.; Coughlin, M.J. (2009). "Prospective Controlled Trial of STAR Total Ankle Replacement Versus Ankle Fusion: Initial Results". Foot & Ankle International 30 (7): 579–596. doi:10.3113/FAI.2009.0579. PMID 19589303.
- Kitaoka, Harold B.; Patzer, Gary L. (1996). "Clinical results of the Mayo total ankle arthroplasty". Journal of Bone and Joint Surgery 78A (11): 1658–64. PMID 8934479.
- Lachiewicz, PF (1994). "Total ankle arthroplasty. Indications, techniques, and results". Orthopaedic Review 23 (4): 315–20. PMID 8008441.
- Giannini, Sandro; Romagnoli, Matteo; O’connor, John J.; Malerba, Francesco; Leardini, Alberto (2010). "Total Ankle Replacement Compatible with Ligament Function Produces Mobility, Good Clinical Scores, and Low Complication Rates: An Early Clinical Assessment". Clinical Orthopaedics and Related Research 468 (10): 2746–53. doi:10.1007/s11999-010-1432-3.
- Saltzman, CL; McIff, TE; Buckwalter, JA; Brown, TD (2000). "Total ankle replacement revisited". Journal of Orthopaedic & Sports Physical Therapy 30 (2): 56–67. PMID 10693083.
- Goodfellow, John; O'Connor, John (1978). "The mechanics of the knee and prosthesis design". Journal of Bone and Joint Surgery 60B (3): 358–69. PMID 581081.
- Haddad, S.L.; Coetzee, J.C.; Estok, R.; Fahrbach, K.; Banel, D.; Nalysnyk, L. (2007). "Intermediate and Long-Term Outcomes of Total Ankle Arthroplasty and Ankle Arthrodesis. A Systematic Review of the Literature". Journal of Bone and Joint Surgery 89A (9): 1899–905. doi:10.2106/JBJS.F.01149. PMID 17768184.
- Stengel, Dirk; Bauwens, Kai; Ekkernkamp, Axel; Cramer, Jörg (2005). "Efficacy of total ankle replacement with meniscal-bearing devices: a systematic review and meta-analysis". Archives of Orthopaedic and Trauma Surgery 125 (2): 109–19. doi:10.1007/s00402-004-0765-3. PMID 15690167.
- Gougoulias, Nikolaos; Khanna, Anil; Maffulli, Nicola (2009). "How Successful are Current Ankle Replacements? All though most total ankle replacement are successful by reducing pain and improving mobility there is a very high possibility that the pain may be ten times worse. There have been several cases where the doctors have recommended amputation to resolve the issue of pain that was not there prior to the total ankle replacement. : A Systematic Review of the Literature". Clinical Orthopaedics and Related Research 468: 199–208. doi:10.1007/s11999-009-0987-3.
- Mann, J.A.; Mann, R.A.; Horton, E. (2011). "STAR ankle: long-term results". Foot Ankle International 32 (5): S473–484. doi:10.3113/FAI.2011.0473. PMID 21733455.
- Conti S, Lalonde KA, Martin R (November 2006). "Kinematic analysis of the agility total ankle during gait". Foot & Ankle International 27 (11): 980–4. PMID 17144964.
- Banks SA, Hodge WA (June 1996). "Accurate measurement of three-dimensional knee replacement kinematics using single-plane fluoroscopy". IEEE Transactions on Bio-medical Engineering 43 (6): 638–49. doi:10.1109/10.495283. PMID 8987268.