In the 1985 NFL Draft, Fralic was selected by the Atlanta Falcons with the second overall pick. He became a starter for the Falcons at offensive guard during his rookie season. He went on to be named All-Pro in 1986 & 1987, and was named to the Pro Bowl from 1986 to 1989. During this time, the 6 ft 5 in (1.96 m), 280 lb (127 kg) Fralic developed a reputation as a ferocious run blocker.
At the end of his NFL career, he was one of the first players to take advantage of the new free agent system and jumped from the Atlanta Falcons to the Detroit Lions, almost doubling his pay to $1.6 million for the 1993 season.
During his NFL career, Fralic publicly opposed the use of steroids by NFL players and advocated more rigorous and more random testing to detect steroid use. In May 1989 he testified before the U.S. Senate that steroid use in the NFL was rampant. The chairman of the Senate Judiciary Committee at the time, Sen. Joe Biden of Delaware, was said to have found Fralic's testimony "refreshing and believable".