Blue nevus

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Blue nevus
Classification and external resources
Blue nevus - intermed mag.jpg
Micrograph of a blue nevus showing the characteristic pigmented melanocytes between bundles of collagen. H&E stain.
ICD-10 D22 (ILDS D22.L42)
DiseasesDB 31098
MeSH D018329

Blue nevus (also known as "Blue neuronevus," "Dermal melanocytoma," and "Nevus bleu"[1]) is a type of melanocytic nevus. The blue colour is caused by the pigment being deeper in the skin than in ordinary nevi. In principle they are harmless[2] but they can sometimes be mimicked by malignant lesions, i.e. some melanomas can look like a blue nevus.[3][4]

Classification[edit]

Blue nevi may be divided into the following types:[5]:701

  • A Patch blue nevus (also known as an "Acquired dermal melanocytosis," and "Dermal melanocyte hamartoma") is a cutaneous condition characterized by a diffusely gray-blue area that may have superimposed darker macules.[1]
  • Blue nevus of Jadassohn–Tièche (also known as a "Common blue nevus," and "Nevus ceruleus") is a cutaneous condition characterized by a steel-blue papule or nodule.[5]:701
  • Cellular blue nevi are a cutaneous condition characterized by large, firm, blue or blue-black nodules.[5]:701
  • Epithelioid blue nevi are a cutaneous condition most commonly seen in patients with the Carney complex.[5]:701
  • A deep penetrating nevus is a type of benign melanocytic skin tumor characterized, as its name suggests, by penetration into the deep dermis and/or subcutis. Smudged chromatic is a typical finding. In some cases mitotic figures or atypical melanocytic cytology are seen, potentially mimicking a malignant melanoma. Evaluation by an expert skin pathologist is advisable in some cases to help differentiate from invasive melanoma.[5]:701
  • An Amelanotic blue nevus (also known as a "Hypomelanotic blue nevus") is a cutaneous condition characterized by mild atypia and pleomorphism.[5]:701
  • A malignant blue nevus is a cutaneous condition characterized by a sheet-like growth pattern, mitoses, necrosis, and cellular atypia.[5]:701[1]

See also[edit]

References[edit]

  1. ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1722. ISBN 1-4160-2999-0. 
  2. ^ "Blue naevus (nevus). DermNet NZ". Retrieved 2009-02-27. 
  3. ^ Blue Nevi at the US National Library of Medicine Medical Subject Headings (MeSH)
  4. ^ Granter SR, McKee PH, Calonje E, Mihm MC, Busam K (March 2001). "Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant blue nevus'". Am. J. Surg. Pathol. 25 (3): 316–23. doi:10.1097/00000478-200103000-00005. PMID 11224601. 
  5. ^ a b c d e f g James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.