|in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.|
Triana & Planch.
Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo. Positive effects of Boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported. A Boswellia extract marketed under the name Wokvel has undergone human efficacy, comparative, pharmacokinetic studies. Some see Boswellia serrata as a promising alternative to NSAIDs, warranting further investigation in pharmacological studies and clinical trials.
Boswellia serrata has been recently developed for topical use in a patent-pending formula in Sano Relief Gel. Boswellia serrata is used in the manufacture of the supposed anti-wrinkle agent "Boswelox", which has been criticised as being ineffective.
Potential for anti-cancer activity
Boswellic acid, an extract from Boswellia serrata, has been studied for anti-neoplastic activity, especially in experimental primary and secondary brain tumors, indicating potential efficacy from in vitro and limited clinical research. Boswellic acid is also undergoing an early-stage clinical trial at the Cleveland Clinic.
Mechanism of action
Animal studies performed in India show ingestion of a defatted alcoholic extract of Boswellia decreased polymorphonuclear leukocyte infiltration and migration, decreased primary antibody synthesis and almost totally inhibited the classical complement pathway.
Shallaki has potent analgesic and anti-inflammatory effects that can reduce the pain and inflammation of joints. 
- Shallaki: Medicinal Uses According To AYurveda
- BBC News Health - Frankincense 'can ease arthritis' Friday 01/08/08
- Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
- "JOINT RELIEF". www.herbcompanion.com. Retrieved 2009-01-12.
- Cameron, M; Chrubasik, S (May 22, 2014). "Oral herbal therapies for treating osteoarthritis". Cochrane Summaries. Retrieved June 6, 2014.
- Ammon HP."Modulation of the immune system by Boswellia serrata extracts and boswellic acids. [Review]" Phytomedicine. 17(11):862-7, 2010 Sep.
- Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian Journal of Pharmacology. 2007; 39(1) 27-29
- Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
- Pharmacokinetic study of 11-Keto beta-Boswellic acid. Phytomedicine. 2004 Feb;11(2-3):255-60.
- Abdel-Tawab M, Werz O, Schubert-Zsilavecz M.,"Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data." Clin Pharmacokinet. 2011 Jun 1;50(6):349-69
- Wrinkle breakthrough claim from L'Oreal
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- Acetyl-11-Keto-β-Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis
- LY294002 Enhances Boswellic Acid-induced Apoptosis in Colon Cancer Cells
- A lipoxygenase inhibitor in breast cancer brain metastases
- Phase II Randomized Evaluation of 5-Lipoxygenase Inhibition by Herbal Medicine Approach Compared to Control as an Adjuvant Therapy in Newly Diagnosed and Recurrent High-Grade Gliomas
- Sharma ML, Khajuria A, 1. Kaul A, et al. Effects of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leukocyte migration. Agents Actions 1988;24:161-164.
- Sharma ML, Bani S, Singh GB. Anti-arthriticactivity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int J Immunopharmacol 1989;11:647-652.
- (Planta Med. 1971 Apr; 19(4): 333-41 for analgesic and psychopharmacological effects of gum resin of Boswalia Serrata by Memon MK)
- Abdel-Tawab M, Werz O, Schubert-Zsilavecz M."Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data." Clin Pharmacokinet. 2011 Jun 1;50(6):349-69