Breakthrough Breast Cancer
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The "Breakthrough Toby Robins Breast Cancer Research Centre", at the Institute of Cancer Research, is the result of more than ten years' work by the organization, envisioned by Bill Freedman and his children. Freedman's wife, actress Toby Robins (1931–1986), died from breast cancer in 1986. With Barry Gusterson of the Institute of Cancer Research, Freedman concluded that a new approach was needed to tackle that disease. They set out to establish a centre of excellence for breast cancer research under one roof, working on a coordinated programme of research. The organization was founded to make this a reality.
In addition to the research centre, Breakthrough has campaigned for better breast cancer services. In November 2003, their "Campaigns & Advocacy Network"  was formed when they merged with the UK Breast Cancer Coalition (UKBCC). The organization works in partnership with other cancer research organisations and is a member of the National Cancer Research Institute.
The "Breakthrough Generations Survey" aims to survey 100,000 women and "plans to be the largest, most comprehensive scientific study into the causes of breast cancer". The survey is being carried out in association with the Institute of Cancer Research. It asks women taking part to complete a comprehensive questionnaire about a wide range of health and lifestyle topics, and to have a blood sample taken, to then be followed up by investigators over the next 50 years.
The charity runs fundraising campaigns throughout the year, including Fashion Targets Breast Cancer, £1,000 Challenge, Go Pink, running events, treks and others.
Marks & Spencer has sold a wide range of charitable women's clothes for them. for many years, and Avon have supported the charity for over 20 years with a range of fundraising products and campaigns.
Breakthrough Breast Cancer launched 'iBreastCheck'  as part of Breast Cancer Awareness Month in 2010. iBreastCheck is a mobile app that is an extension of the TLC campaign (see above), incorporating a TLC video, slideshow and reminder service, personalised breast cancer risk report, and information on Breakthrough's activities and how to get involved. Initially available for iPhones, an Android version was released in 2012.
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- Breakthrough Breast Cancer, Registered Charity no. 1062636 at the Charity Commission