Magnification. The Brushfield spots are the spots between the inner and outer red circles.
Brushfield spots are small white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal iris element. The spots are named after the physician Thomas Brushfield, who first described them in his 1924 M.D. thesis.
These spots are normal in children (Kunkmann-Wolffian bodies) but are also a feature of the chromosomal disorder Down syndrome. They occur in 35–78% of newborn infants with Down syndrome. They are much more likely to occur in children with Down syndrome of the Caucasian race than children of Asian heritage with Down's Syndrome.