CAZy

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This article is about the database. For the community in the United States, see Cazy, West Virginia.

CAZy is a database of Carbohydrate-Active enZYmes.[1] This database contains a classification and associated information about enyzmes involved in the synthesis, metabolism, and transport of carbohydrates. Included in this database are glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterase and carbohydrate-binding families.

Classification[edit]

CAZy identifies evolutionary related families of glycosyl hydrolases using the classification introduced by Bernard Henrissat.[2][3] As of 2012 CAZy contains 131 families of glycosyl hydrolase families. These families are given a number to identify them, so for example Glycosyl hydrolase family 1 contains enzymes that possess a TIM barrel fold. These families are clustered into 14 different clans that share structural similarity. CAZy contains 94 families of Glycosyl transferase enzymes,[4] 22 families of polysaccharide lysases[5] and 16 families of carbohydrate esterases.

References[edit]

  1. ^ Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009). "The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics". Nucleic Acids Res. 37 (Database issue): D233–8. doi:10.1093/nar/gkn663. PMC 2686590. PMID 18838391. 
  2. ^ Henrissat, B. (1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical journal. 280 ( Pt 2) (Pt 2): 309–316. PMC 1130547. PMID 1747104.  edit
  3. ^ Henrissat, B.; Davies, G. (1997). "Structural and sequence-based classification of glycoside hydrolases". Current opinion in structural biology 7 (5): 637–644. doi:10.1016/S0959-440X(97)80072-3. PMID 9345621.  edit
  4. ^ Coutinho, P. M.; Deleury, E.; Davies, G. J.; Henrissat, B. (2003). "An evolving hierarchical family classification for glycosyltransferases". Journal of Molecular Biology 328 (2): 307–317. doi:10.1016/S0022-2836(03)00307-3. PMID 12691742.  edit
  5. ^ Lombard, V.; Bernard, T.; Rancurel, C.; Brumer, H.; Coutinho, P. M.; Henrissat, B. (2010). "A hierarchical classification of polysaccharide lyases for glycogenomics". Biochemical Journal 432 (3): 437–444. doi:10.1042/BJ20101185. PMID 20925655.  edit

External links[edit]