CDC45-related protein

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cell division cycle 45
Identifiers
Symbols CDC45 ; CDC45L; CDC45L2; PORC-PI-1
External IDs OMIM603465 MGI1338073 HomoloGene2616 ChEMBL: 3040 GeneCards: CDC45 Gene
RNA expression pattern
PBB GE CDC45L 204126 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8318 12544
Ensembl ENSG00000093009 ENSMUSG00000000028
UniProt O75419 Q9Z1X9
RefSeq (mRNA) NM_001178010 NM_001161623
RefSeq (protein) NP_001171481 NP_001155095
Location (UCSC) Chr 22:
19.47 – 19.51 Mb
Chr 16:
18.78 – 18.81 Mb
PubMed search [1] [2]

CDC45 is a protein that in humans is encoded by the CDC45L gene.[1][2][3][4]

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.[4]

Interactions[edit]

CDC45-related protein has been shown to interact with ORC1L,[5] MCM6,[5] MCM7,[5][6] MCM3[5] and ORC6L.[5]

References[edit]

  1. ^ Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A (Aug 1998). "The human homolog of Saccharomyces cerevisiae CDC45". J Biol Chem 273 (29): 18205–9. doi:10.1074/jbc.273.29.18205. PMID 9660782. 
  2. ^ McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ (Sep 1998). "Direct Selection of Conserved cDNAs from the DiGeorge Critical Region: Isolation of a Novel CDC45-Like Gene". Genome Res 8 (8): 834–41. doi:10.1101/gr.8.8.834. PMC 310757. PMID 9724329. 
  3. ^ Pollok S, Bauerschmidt C, Sanger J, Nasheuer HP, Grosse F (Jul 2007). "Human Cdc45 is a proliferation-associated antigen". FEBS J 274 (14): 3669–84. doi:10.1111/j.1742-4658.2007.05900.x. PMID 17608804. 
  4. ^ a b "Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)". 
  5. ^ a b c d e Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  6. ^ Kukimoto, I; Igaki H; Kanda T (Nov 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. (GERMANY) 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. ISSN 0014-2956. PMID 10518787. 

Further reading[edit]