CLDN19

CLDN19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3X29
Identifiers
Aliases	CLDN19, HOMG5, claudin 19
External IDs	OMIM: 610036 MGI: 3033992 HomoloGene: 17528 GeneCards: CLDN19
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,740,254 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,119,635 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; spinal ganglia; ; retinal pigment epithelium; ; renal medulla; ; tibial nerve; ; vena cava; ; body of tongue; ; ventral tegmental area; ; trachea; ; superior surface of tongue;
	Top expressed in
	sciatic nerve; ; inner renal medulla; ; outer renal medulla; ; spinal ganglia; ; lip; ; kidney; ; lens; ; proximal tubule; ; yolk sac; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; identical protein binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; cell junction; plasma membrane; basolateral plasma membrane; apical junction complex; nucleus; bicellular tight junction; membrane;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; apical junction assembly; neuronal action potential propagation; response to stimulus; visual perception; tight junction organization;
	Sources:Amigo / QuickGO
Orthologs
	149461
	242653
	ENSG00000164007
	ENSMUSG00000066058
	Q8N6F1
	Q9ET38
	NM_148960; NM_001123395; NM_001185117
	NM_001038590; NM_153105
	NP_001116867; NP_001172046; NP_683763
	NP_001033679; NP_694745
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.^[5] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164007 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066058 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLDN19 claudin 19".
^ Naeem, M.; Hussain, S.; Akhtar, N. (2011). "Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular Disease". American Journal of Nephrology. 34 (3): 241–248. doi:10.1159/000330854. PMID 21791920.
^ Konrad, M.; Schaller, A.; Seelow, D.; Pandey, A. V.; Waldegger, S.; Lesslauer, A.; Vitzthum, H.; Suzuki, Y.; Luk, J. M.; Becker, C.; Schlingmann, K. P.; Schmid, M.; Rodriguez-Soriano, J.; Ariceta, G.; Cano, F.; Enriquez, R.; Jüppner, H.; Bakkaloglu, S. A.; Hediger, M. A.; Gallati, S.; Neuhauss, S. C. F.; Nürnberg, P.; Weber, S. (2006). "Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement". The American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.

References

Further reading