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Component of oligomeric golgi complex 5
Symbols COG5 ; CDG2I; GOLTC1; GTC90
External IDs OMIM606821 HomoloGene42221 GeneCards: COG5 Gene
RNA expression pattern
PBB GE COG5 203629 s at tn.png
PBB GE COG5 203630 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10466 238123
Ensembl ENSG00000164597 ENSMUSG00000035933
UniProt Q9UP83 Q8C0L8
RefSeq (mRNA) NM_001161520 NM_001163126
RefSeq (protein) NP_001154992 NP_001156598
Location (UCSC) Chr 7:
106.84 – 107.2 Mb
Chr 12:
31.65 – 31.94 Mb
PubMed search [1] [2]

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.[1][2][3]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM][3]


COG5 has been shown to interact with COG7[4] and COG4.[4]


  1. ^ Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport". J Biol Chem 273 (45): 29565–76. doi:10.1074/jbc.273.45.29565. PMID 9792665. 
  2. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916. 
  3. ^ a b "Entrez Gene: COG5 component of oligomeric golgi complex 5". 
  4. ^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 

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