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Corin, serine peptidase
Symbols CORIN ; ATC2; CRN; Lrp4; PEE5; TMPRSS10
External IDs OMIM605236 MGI1349451 HomoloGene4804 GeneCards: CORIN Gene
RNA expression pattern
PBB GE CORIN 220356 at tn.png
More reference expression data
Species Human Mouse
Entrez 10699 53419
Ensembl ENSG00000145244 ENSMUSG00000005220
UniProt Q9Y5Q5 Q9Z319
RefSeq (mRNA) NM_001278585 NM_001122756
RefSeq (protein) NP_001265514 NP_001116228
Location (UCSC) Chr 4:
47.6 – 47.84 Mb
Chr 5:
72.3 – 72.5 Mb
PubMed search [1] [2]
Not to be confused with Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4.

Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.[1][2]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.[2]


  1. ^ Yan W, Sheng N, Seto M, Morser J, Wu Q (Jul 1999). "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart". J Biol Chem 274 (21): 14926–35. doi:10.1074/jbc.274.21.14926. PMID 10329693. 
  2. ^ a b "Entrez Gene: CORIN corin, serine peptidase". 

Further reading[edit]