CORIN

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Corin, serine peptidase
Identifiers
Symbols CORIN ; ATC2; CRN; Lrp4; PEE5; TMPRSS10
External IDs OMIM605236 MGI1349451 HomoloGene4804 GeneCards: CORIN Gene
RNA expression pattern
PBB GE CORIN 220356 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10699 53419
Ensembl ENSG00000145244 ENSMUSG00000005220
UniProt Q9Y5Q5 Q9Z319
RefSeq (mRNA) NM_001278585 NM_001122756
RefSeq (protein) NP_001265514 NP_001116228
Location (UCSC) Chr 4:
47.6 – 47.84 Mb
Chr 5:
72.3 – 72.5 Mb
PubMed search [1] [2]
Not to be confused with Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4.

Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.[1][2]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.[2]

References[edit]

  1. ^ Yan W, Sheng N, Seto M, Morser J, Wu Q (Jul 1999). "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart". J Biol Chem 274 (21): 14926–35. doi:10.1074/jbc.274.21.14926. PMID 10329693. 
  2. ^ a b "Entrez Gene: CORIN corin, serine peptidase". 

Further reading[edit]