CORIN

Corin, serine peptidase
Identifiers
Symbols	CORIN; ATC2; CRN; Lrp4; MGC119742; TMPRSS10
External IDs	OMIM: 605236 MGI: 1349451 HomoloGene: 4804 GeneCards: CORIN Gene
Gene Ontology Molecular function • serine-type endopeptidase activity • scavenger receptor activity • peptidase activity • serine-type exopeptidase activity Cellular component • plasma membrane • cell surface • integral to membrane Biological process • regulation of systemic arterial blood pressure by atrial natriuretic peptide • peptide hormone processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10699	53419
Ensembl	ENSG00000145244	ENSMUSG00000005220
UniProt	Q9Y5Q5	Q566K6
RefSeq (mRNA)	NM_006587	NM_016869
RefSeq (protein)	NP_006578	NP_058565
Location (UCSC)	Chr 4: 47.6 – 47.84 Mb	Chr 5: 72.69 – 72.9 Mb
PubMed search	[1]	[2]

Not to be confused with Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4.

Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Further reading

• Yan W, Wu F, Morser J, Wu Q (2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8525–9. doi:10.1073/pnas.150149097. PMC 26981. PMID 10880574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26981. 
• Hooper JD, Scarman AL, Clarke BE, et al. (2001). "Localization of the mosaic transmembrane serine protease corin to heart myocytes". Eur. J. Biochem. 267 (23): 6931–7. doi:10.1046/j.1432-1033.2000.01806.x. PMID 11082206. 
• Wu F, Yan W, Pan J, et al. (2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". J. Biol. Chem. 277 (19): 16900–5. doi:10.1074/jbc.M201503200. PMID 11884416. 
• Pan J, Hinzmann B, Yan W, et al. (2002). "Genomic structures of the human and murine corin genes and functional GATA elements in their promoters". J. Biol. Chem. 277 (41): 38390–8. doi:10.1074/jbc.M205686200. PMID 12154094. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Knappe S, Wu F, Masikat MR, et al. (2004). "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin". J. Biol. Chem. 278 (52): 52363–70. doi:10.1074/jbc.M309991200. PMID 14559895. 
• Knappe S, Wu F, Madlansacay MR, Wu Q (2004). "Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide". J. Biol. Chem. 279 (33): 34464–71. doi:10.1074/jbc.M405041200. PMID 15192093. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Dries DL, Victor RG, Rame JE, et al. (2006). "Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension". Circulation 112 (16): 2403–10. doi:10.1161/CIRCULATIONAHA.105.568881. PMID 16216958. 
• Rame JE, Drazner MH, Post W, et al. (2007). "Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload". Hypertension 49 (4): 857–64. doi:10.1161/01.HYP.0000258566.95867.9e. PMID 17296875. 
• Liao X, Wang W, Chen S, Wu Q (2007). "Role of glycosylation in corin zymogen activation". J. Biol. Chem. 282 (38): 27728–35. doi:10.1074/jbc.M703687200. PMID 17660514.