Cadherin cytoplasmic region
In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn). The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.
- Yap AS, Niessen CM, Gumbiner BM (May 1998). "The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn". J. Cell Biol. 141 (3): 779–89. doi:10.1083/jcb.141.3.779. PMC 2132752. PMID 9566976.
- Nagafuchi A, Takeichi M (December 1988). "Cell binding function of E-cadherin is regulated by the cytoplasmic domain". EMBO J. 7 (12): 3679–84. PMC 454940. PMID 3061804.