In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood. In cartilaginous fishes (e.g. sharks and rays) and agnathans (e.g. lampreys and hagfish), the chondrocranium persists throughout life. Embryologically, the chondrocranium represents the basal cranial structure, and lays the base for the formation of the endocranium in higher vertebrates.
The portion of the chondrocranium that is associated with the notochord is termed the chordal chondrocranium and is formed from mesodermally-derived mesenchyme. The more rostral portion of the chondrocranium that lie anterior to the notochord constitutes the prechordal chondrocranium, and is derived primarily from neural crest-derived mesenchyme.
- Salentijn, L. Biology of Mineralized Tissues: Prenatal Skull Development, Columbia University College of Dental Medicine post-graduate dental lecture series, 2007
- Kent, G.C & Miller, L. (1997): Comparative Anatomy of the Vertebrates. Wm. C. Brown Publishers. ISBN 0-697-24378-8.
- Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 216–247. ISBN 0-03-910284-X.
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