Clodronic acid

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Clodronic acid
Clodronic acid.png
Systematic (IUPAC) name
(dichloro-phosphono-methyl)phosphonic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 10596-23-3 YesY
ATC code M05BA02
PubChem CID 25419
DrugBank DB00720
ChemSpider 23731 YesY
UNII 0813BZ6866 YesY
KEGG D03545 YesY
ChEBI CHEBI:110423 YesY
ChEMBL CHEMBL12318 YesY
Chemical data
Formula CH4Cl2O6P2 
Mol. mass 244.892 g/mol
 YesY (what is this?)  (verify)

Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa.

An Italian study compared the analgesic effect of clodronic acid versus acetaminophen in reumatic condition related pain. Study result show a reduction in pain in favor of clodronic acid that provided more analgesia than 3 grams/day of acetaminophen. Clodronate is also used in experimental medicine to selectively deplete macrophages.

Clodronic acid is approved for human use in Canada and Australia, the United Kingdom, where it is marketed as Bonefos, Loron, Clodron and in Italy as Clasteon, Difosfonal, Osteostab and several generics. In other countries is prescribed as a bone resorption inhibitor and antihypercalcemic agent.