DEAD/DEAH box helicase

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DEAD/DEAH box helicase
PDB 1qva EBI.jpg
Structure of the amino terminal domain of yeast initiation factor 4A.[1]
Symbol DEAD
Pfam PF00270
Pfam clan CL0023
InterPro IPR011545
SCOP 1qva
CDD cd00046

The DEAD/DEAH box helicases are a family of proteins whose purpose is to unwind nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.[2][3]


  1. ^ Johnson ER, McKay DB (December 1999). "Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase". RNA 5 (12): 1526–34. doi:10.1017/S1355838299991410. PMC 1369875. PMID 10606264. 
  2. ^ de la Cruz J, Kressler D, Linder P (May 1999). "Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families". Trends Biochem. Sci. 24 (5): 192–8. doi:10.1016/S0968-0004(99)01376-6. PMID 10322435. 
  3. ^ Aubourg S, Kreis M, Lecharny A (January 1999). "The DEAD box RNA helicase family in Arabidopsis thaliana". Nucleic Acids Res. 27 (2): 628–36. doi:10.1093/nar/27.2.628. PMC 148225. PMID 9862990. 

This article incorporates text from the public domain Pfam and InterPro IPR011545