This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. [provided by RefSeq, Oct 2010].
Yuan, J.; Luo, R. Z.; Fujii, S.; Wang, L.; Hu, W.; Andreeff, M.; Pan, Y.; Kadota, M.; Oshimura, M.; Sahin, A. A.; Issa, J. P.; Bast Jr, R. C.; Yu, Y. (2003). "Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers". Cancer research63 (14): 4174–4180. PMID12874023.edit
Lu, X.; Qian, J.; Yu, Y.; Yang, H.; Li, J. (2009). "Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest". Oncology reports22 (3): 635–640. PMID19639215.edit
Pei, X. H.; Yang, Z.; Liu, H. X.; Qiao, S. S. (2011). "Aplasia Ras homologue member I overexpression induces apoptosis through inhibition of survival pathways in human hepatocellular carcinoma cells in culture and in xenograft". Cell Biology International35 (10): 1019–1024. doi:10.1042/CBI20110023. PMID21933150.edit
Shi, Z.; Zhou, X.; Xu, L.; Zhang, T.; Hou, Y.; Zhu, W.; Zhang, T. (2002). "NOEY2 gene mRNA expression in breast cancer tissue and its relation to clinicopathological parameters". Zhonghua zhong liu za zhi \Chinese journal of oncology]24 (5): 475–478. PMID12485503.edit
Li, B. X.; Li, J.; Luo, C. L.; Zhang, M. C.; Li, H.; Li, L. L.; Xu, H. F.; Shen, Y. W.; Xue, A. M.; Zhao, Z. Q. (2013). "Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma". Indian journal of experimental biology51 (3): 208–217. PMID23678541.edit
Janssen, E. A.; Øvestad, I. T.; Skaland, I.; Søiland, H.; Gudlaugsson, E.; Kjellevold, K. H.; Nysted, A.; Søreide, J. A.; Baak, J. P. (2009). "LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer". Cellular oncology : the official journal of the International Society for Cellular Oncology31 (5): 335–343. doi:10.3233/CLO-2009-0479. PMID19759414.edit