DIRAS3 (gene)

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DIRAS family, GTP-binding RAS-like 3
Symbols DIRAS3 ; ARHI; NOEY2
External IDs OMIM605193 HomoloGene48296 GeneCards: DIRAS3 Gene
Species Human Mouse
Entrez 9077 n/a
Ensembl ENSG00000162595 n/a
UniProt O95661 n/a
RefSeq (mRNA) NM_004675 n/a
RefSeq (protein) NP_004666 n/a
Location (UCSC) Chr 1:
68.51 – 68.52 Mb
PubMed search [1] n/a

DIRAS family, GTP-binding RAS-like 3 is a protein that in humans is encoded by the DIRAS3 gene. [1]


This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. [provided by RefSeq, Oct 2010].


Further reading[edit]

  • Baljuls, A.; Beck, M.; Oenel, A.; Robubi, A.; Kroschewski, R.; Hekman, M.; Rudel, T.; Rapp, U. R. (2012). "The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF". Journal of Biological Chemistry 287 (27): 23128–23140. doi:10.1074/jbc.M112.343780. PMC 3391090. PMID 22605333.  edit
  • Yuan, J.; Luo, R. Z.; Fujii, S.; Wang, L.; Hu, W.; Andreeff, M.; Pan, Y.; Kadota, M.; Oshimura, M.; Sahin, A. A.; Issa, J. P.; Bast Jr, R. C.; Yu, Y. (2003). "Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers". Cancer research 63 (14): 4174–4180. PMID 12874023.  edit
  • Lu, X.; Qian, J.; Yu, Y.; Yang, H.; Li, J. (2009). "Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest". Oncology reports 22 (3): 635–640. PMID 19639215.  edit
  • Yu, Y.; Xu, F.; Peng, H.; Fang, X.; Zhao, S.; Li, Y.; Cuevas, B.; Kuo, W. L.; Gray, J. W.; Siciliano, M.; Mills, G. B.; Bast Jr, R. C. (1999). "NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 214–219. doi:10.1073/pnas.96.1.214. PMC 15119. PMID 9874798.  edit
  • Yang, J.; Hu, A.; Wang, L.; Li, B.; Chen, Y.; Zhao, W.; Xu, W.; Li, T. (2009). "NOEY2 mutations in primary breast cancers and breast hyperplasia". The Breast 18 (3): 197–203. doi:10.1016/j.breast.2009.04.004. PMID 19482475.  edit
  • Pei, X. H.; Yang, Z.; Liu, H. X.; Qiao, S. S. (2011). "Aplasia Ras homologue member I overexpression induces apoptosis through inhibition of survival pathways in human hepatocellular carcinoma cells in culture and in xenograft". Cell Biology International 35 (10): 1019–1024. doi:10.1042/CBI20110023. PMID 21933150.  edit
  • Shi, Z.; Zhou, X.; Xu, L.; Zhang, T.; Hou, Y.; Zhu, W.; Zhang, T. (2002). "NOEY2 gene mRNA expression in breast cancer tissue and its relation to clinicopathological parameters". Zhonghua zhong liu za zhi \Chinese journal of oncology] 24 (5): 475–478. PMID 12485503.  edit
  • Li, B. X.; Li, J.; Luo, C. L.; Zhang, M. C.; Li, H.; Li, L. L.; Xu, H. F.; Shen, Y. W.; Xue, A. M.; Zhao, Z. Q. (2013). "Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma". Indian journal of experimental biology 51 (3): 208–217. PMID 23678541.  edit
  • Janssen, E. A.; Øvestad, I. T.; Skaland, I.; Søiland, H.; Gudlaugsson, E.; Kjellevold, K. H.; Nysted, A.; Søreide, J. A.; Baak, J. P. (2009). "LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer". Cellular oncology : the official journal of the International Society for Cellular Oncology 31 (5): 335–343. doi:10.3233/CLO-2009-0479. PMID 19759414.  edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.