DNMT1

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DNA (cytosine-5-)-methyltransferase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DNMT1 ; ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT
External IDs OMIM126375 MGI94912 HomoloGene124071 ChEMBL: 1993 GeneCards: DNMT1 Gene
EC number 2.1.1.37
RNA expression pattern
PBB GE DNMT1 201697 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1786 13433
Ensembl ENSG00000130816 ENSMUSG00000004099
UniProt P26358 P13864
RefSeq (mRNA) NM_001130823 NM_001199431
RefSeq (protein) NP_001124295 NP_001186360
Location (UCSC) Chr 19:
10.24 – 10.34 Mb
Chr 9:
20.91 – 20.96 Mb
PubMed search [1] [2]

DNA (cytosine-5)-methyltransferase 1 is an enzyme that in humans is encoded by the DNMT1 gene.[1]

Function[edit]

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.[2][3]

See also[edit]

Interactions[edit]

DNMT1 has been shown to interact with UHRF1,:

References[edit]

  1. ^ Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB (June 1992). "Isolation and characterization of the cDNA encoding human DNA methyltransferase". Nucleic Acids Res 20 (9): 2287–91. doi:10.1093/nar/20.9.2287. PMC 312343. PMID 1594447. 
  2. ^ Klein CJ, Botuyan MV, Wu Y, Ward CJ, Nicholson GA, Hammans S, Hojo K, Yamanishi H, Karpf AR, Wallace DC, Simon M, Lander C, Boardman LA, Cunningham JM, Smith GE, Litchy WJ, Boes B, Atkinson EJ, Middha S, B Dyck PJ, Parisi JE, Mer G, Smith DI, Dyck PJ (2011). "Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss". Nat. Genet. 43 (6): 595–600. doi:10.1038/ng.830. PMC 3102765. PMID 21532572. 
  3. ^ "Entrez Gene: DNMT1 DNA (cytosine-5-)-methyltransferase 1". 
  4. ^ a b c Rountree MR, Bachman KE, Baylin SB (July 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat. Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872. 
  5. ^ a b Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S (August 2002). "Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases". EMBO J. 21 (15): 4183–95. doi:10.1093/emboj/cdf401. PMC 126147. PMID 12145218. 
  6. ^ Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH (July 2003). "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin". Curr. Biol. 13 (14): 1192–200. doi:10.1016/s0960-9822(03)00432-9. PMID 12867029. 
  7. ^ Iida T, Suetake I, Tajima S, Morioka H, Ohta S, Obuse C, Tsurimoto T (October 2002). "PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA". Genes Cells 7 (10): 997–1007. doi:10.1046/j.1365-2443.2002.00584.x. PMID 12354094. 
  8. ^ Chuang LS, Ian HI, Koh TW, Ng HH, Xu G, Li BF (September 1997). "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1". Science 277 (5334): 1996–2000. doi:10.1126/science.277.5334.1996. PMID 9302295. 
  9. ^ Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP (July 2000). "DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters". Nat. Genet. 25 (3): 338–42. doi:10.1038/77124. PMID 10888886. 

Further reading[edit]

External links[edit]