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Euchromatic histone-lysine N-methyltransferase 2
Protein EHMT2 PDB 2o8j.png
PDB rendering based on 2o8j.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EHMT2 ; BAT8; C6orf30; G9A; GAT8; KMT1C; NG36
External IDs OMIM604599 MGI2148922 HomoloGene48460 ChEMBL: 6032 GeneCards: EHMT2 Gene
EC number
RNA expression pattern
PBB GE EHMT2 202326 at tn.png
PBB GE EHMT2 207484 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10919 110147
Ensembl ENSG00000204371 ENSMUSG00000013787
UniProt Q96KQ7 Q9Z148
RefSeq (mRNA) NM_006709 NM_145830
RefSeq (protein) NP_006700 NP_665829
Location (UCSC) Chr 6:
31.85 – 31.87 Mb
Chr 17:
34.9 – 34.91 Mb
PubMed search [1] [2]

Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 is a histone methyltransferase that in humans is encoded by the EHMT2 gene.[1][2][3]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.[3]


EHMT2 has been shown to interact with KIAA0515.[4]


  1. ^ Milner CM, Campbell RD (April 1993). "The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats". Biochem J. 290 ( Pt 3) (Pt 3): 811–8. PMC 1132354. PMID 8457211. 
  2. ^ Tachibana M, Sugimoto K, Fukushima T, Shinkai Y (July 2001). "Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3". J Biol Chem 276 (27): 25309–17. doi:10.1074/jbc.M101914200. PMID 11316813. 
  3. ^ a b "Entrez Gene: EHMT2 euchromatic histone-lysine N-methyltransferase 2". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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