DOK1

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Docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DOK1 ; P62DOK
External IDs OMIM602919 MGI893587 HomoloGene1057 GeneCards: DOK1 Gene
Orthologs
Species Human Mouse
Entrez 1796 13448
Ensembl ENSG00000115325 ENSMUSG00000068335
UniProt Q99704 P97465
RefSeq (mRNA) NM_001197260 NM_010070
RefSeq (protein) NP_001184189 NP_034200
Location (UCSC) Chr 2:
74.78 – 74.78 Mb
Chr 6:
83.03 – 83.03 Mb
PubMed search [1] [2]

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.[1][2][3]

Function[edit]

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.[4]

Interactions[edit]

DOK1 has been shown to interact with:

References[edit]

  1. ^ Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B (February 1997). "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells". Cell 88 (2): 197–204. doi:10.1016/S0092-8674(00)81840-1. PMID 9008160. 
  2. ^ Nelms K, Snow AJ, Noben-Trauth K (December 1998). "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia". Genomics 53 (2): 243–5. doi:10.1006/geno.1998.5514. PMID 9790776. 
  3. ^ Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (February 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells". J Biol Chem 280 (5): 3151–8. doi:10.1074/jbc.M411035200. PMID 15546884. 
  4. ^ "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)". 
  5. ^ a b c d van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood 96 (10): 3406–13. PMID 11071635. 
  6. ^ a b Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell 88 (2): 205–11. doi:10.1016/s0092-8674(00)81841-3. PMID 9008161. 
  7. ^ a b c Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908. 
  8. ^ a b c Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/s0898-6568(00)00073-5. PMID 10822173. 
  9. ^ Némorin JG, Duplay P (May 2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. PMID 10799545. 
  10. ^ Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M (September 2002). "Role of Dok1 in cell signaling mediated by RET tyrosine kinase". J. Biol. Chem. 277 (36): 32781–90. doi:10.1074/jbc.M202336200. PMID 12087092. 
  11. ^ Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (June 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966. 

Further reading[edit]