TEC (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tec protein tyrosine kinase
Protein TEC PDB 1gl5.png
PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEC ; PSCTK4
External IDs OMIM600583 MGI98662 HomoloGene1302 ChEMBL: 4246 GeneCards: TEC Gene
EC number
RNA expression pattern
PBB GE TEC 206301 at tn.png
More reference expression data
Species Human Mouse
Entrez 7006 21682
Ensembl ENSG00000135605 ENSMUSG00000029217
UniProt P42680 P24604
RefSeq (mRNA) NM_003215 NM_001113460
RefSeq (protein) NP_003206 NP_001106931
Location (UCSC) Chr 4:
48.14 – 48.27 Mb
Chr 5:
72.76 – 72.87 Mb
PubMed search [1] [2]

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]


TEC (gene) has been shown to interact with GNA12,[3] Janus kinase 2,[4][5] CD117,[6][7] Suppressor of cytokine signaling 1,[8] ARHGEF12[3] and DOK1.[6][9]


  1. ^ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (November 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72. PMID 7934162. 
  2. ^ a b "Entrez Gene: TEC tec protein tyrosine kinase". 
  3. ^ a b Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  4. ^ Takahashi-Tezuka, M; Hibi M; Fujitani Y; Fukada T; Yamaguchi T; Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene (ENGLAND) 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. ISSN 0950-9232. PMID 9178903. 
  5. ^ Yamashita, Y; Watanabe S, Miyazato A, Ohya K i, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (March 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood (UNITED STATES) 91 (5): 1496–507. ISSN 0006-4971. PMID 9473212. 
  6. ^ a b van Dijk, T B; van Den Akker E; Amelsvoort M P; Mano H; Löwenberg B; von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood (UNITED STATES) 96 (10): 3406–13. ISSN 0006-4971. PMID 11071635. 
  7. ^ Tang, B; Mano H; Yi T; Ihle J N (December 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. (UNITED STATES) 14 (12): 8432–7. ISSN 0270-7306. PMC 359382. PMID 7526158. 
  8. ^ Ohya, K i; Kajigaya S; Yamashita Y; Miyazato A; Hatake K; Miura Y; Ikeda U; Shimada K; Ozawa K; Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. ISSN 0021-9258. PMID 9341160. 
  9. ^ Liang, Xiquan; Wisniewski David, Strife Annabel, Shivakrupa , Clarkson Bayard, Resh Marilyn D (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. (United States) 277 (16): 13732–8. doi:10.1074/jbc.M200277200. ISSN 0021-9258. PMID 11825908. 

Further reading[edit]