TEC (gene)

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Tec protein tyrosine kinase
Protein TEC PDB 1gl5.png
PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TEC ; PSCTK4
External IDs OMIM600583 MGI98662 HomoloGene1302 IUPHAR: 2238 ChEMBL: 4246 GeneCards: TEC Gene
EC number 2.7.10.2
RNA expression pattern
PBB GE TEC 206301 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7006 21682
Ensembl ENSG00000135605 ENSMUSG00000029217
UniProt P42680 P24604
RefSeq (mRNA) NM_003215 NM_001113460
RefSeq (protein) NP_003206 NP_001106931
Location (UCSC) Chr 4:
48.14 – 48.27 Mb
Chr 5:
72.76 – 72.87 Mb
PubMed search [1] [2]

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

Function[edit]

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]

Interactions[edit]

TEC (gene) has been shown to interact with:

References[edit]

  1. ^ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72. PMID 7934162. 
  2. ^ a b "Entrez Gene: TEC tec protein tyrosine kinase". 
  3. ^ a b Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866. 
  4. ^ a b van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (Nov 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood 96 (10): 3406–13. PMID 11071635. 
  5. ^ Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology 14 (12): 8432–7. PMC 359382. PMID 7526158. 
  6. ^ Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908. 
  7. ^ Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903. 
  8. ^ Yamashita Y, Watanabe S, Miyazato A, Ohya K, Ikeda U, Shimada K et al. (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood 91 (5): 1496–507. PMID 9473212. 
  9. ^ Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y et al. (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160. 

Further reading[edit]

  • Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews 10 (3-4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781. 
  • Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735. 
  • Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene 5 (12): 1781–6. PMID 2284097. 
  • Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology 14 (12): 8432–7. PMC 359382. PMID 7526158. 
  • Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene 11 (4): 619–25. PMID 7651724. 
  • Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal 10 (5): 637–42. PMID 8621063. 
  • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM et al. (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002. 
  • Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C et al. (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736. 
  • Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O et al. (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene 12 (4): 937–42. PMID 8632917. 
  • Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ et al. (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology 157 (9): 3791–5. PMID 8892607. 
  • Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903. 
  • Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B et al. (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487. 
  • Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y et al. (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160. 
  • Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood 91 (3): 940–8. PMID 9446655. 
  • Yamashita Y, Watanabe S, Miyazato A, Ohya K, Ikeda U, Shimada K et al. (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood 91 (5): 1496–507. PMID 9473212. 
  • Yang WC, Ghiotto M, Barbarat B, Olive D (Jan 1999). "The role of Tec protein-tyrosine kinase in T cell signaling". The Journal of Biological Chemistry 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994. 
  • Yang WC, Olive D (Jun 1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". European Journal of Immunology 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746. 
  • Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y et al. (Oct 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proceedings of the National Academy of Sciences of the United States of America 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.