TEC (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tec protein tyrosine kinase
Protein TEC PDB 1gl5.png
PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TEC ; PSCTK4
External IDs OMIM600583 MGI98662 HomoloGene1302 ChEMBL: 4246 GeneCards: TEC Gene
EC number 2.7.10.2
RNA expression pattern
PBB GE TEC 206301 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7006 21682
Ensembl ENSG00000135605 ENSMUSG00000029217
UniProt P42680 P24604
RefSeq (mRNA) NM_003215 NM_001113460
RefSeq (protein) NP_003206 NP_001106931
Location (UCSC) Chr 4:
48.14 – 48.27 Mb
Chr 5:
72.76 – 72.87 Mb
PubMed search [1] [2]

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]

Interactions[edit]

TEC (gene) has been shown to interact with GNA12,[3] Janus kinase 2,[4][5] CD117,[6][7] Suppressor of cytokine signaling 1,[8] ARHGEF12[3] and DOK1.[6][9]

References[edit]

  1. ^ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (November 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72. PMID 7934162. 
  2. ^ a b "Entrez Gene: TEC tec protein tyrosine kinase". 
  3. ^ a b Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  4. ^ Takahashi-Tezuka, M; Hibi M; Fujitani Y; Fukada T; Yamaguchi T; Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene (ENGLAND) 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. ISSN 0950-9232. PMID 9178903. 
  5. ^ Yamashita, Y; Watanabe S, Miyazato A, Ohya K i, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (March 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood (UNITED STATES) 91 (5): 1496–507. ISSN 0006-4971. PMID 9473212. 
  6. ^ a b van Dijk, T B; van Den Akker E; Amelsvoort M P; Mano H; Löwenberg B; von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood (UNITED STATES) 96 (10): 3406–13. ISSN 0006-4971. PMID 11071635. 
  7. ^ Tang, B; Mano H; Yi T; Ihle J N (December 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. (UNITED STATES) 14 (12): 8432–7. ISSN 0270-7306. PMC 359382. PMID 7526158. 
  8. ^ Ohya, K i; Kajigaya S; Yamashita Y; Miyazato A; Hatake K; Miura Y; Ikeda U; Shimada K; Ozawa K; Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. ISSN 0021-9258. PMID 9341160. 
  9. ^ Liang, Xiquan; Wisniewski David, Strife Annabel, Shivakrupa , Clarkson Bayard, Resh Marilyn D (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. (United States) 277 (16): 13732–8. doi:10.1074/jbc.M200277200. ISSN 0021-9258. PMID 11825908. 

Further reading[edit]

  • Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine Growth Factor Rev. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781. 
  • Yang WC, Collette Y, Nunès JA, Olive D (2000). "Tec kinases: a family with multiple roles in immunity". Immunity 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735. 
  • Mano H; Ishikawa F; Nishida J et al. (1991). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene 5 (12): 1781–6. PMID 2284097. 
  • Tang B, Mano H, Yi T, Ihle JN (1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. 14 (12): 8432–7. PMC 359382. PMID 7526158. 
  • Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene 11 (4): 619–25. PMID 7651724. 
  • Mano H; Yamashita Y; Miyazato A et al. (1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB J. 10 (5): 637–42. PMID 8621063. 
  • Rawlings DJ; Scharenberg AM; Park H et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002. 
  • Park H; Wahl MI; Afar DE et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736. 
  • Ohta Y; Haire RN; Amemiya CT et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene 12 (4): 937–42. PMID 8632917. 
  • Cory GO; MacCarthy-Morrogh L; Banin S et al. (1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". J. Immunol. 157 (9): 3791–5. PMID 8892607. 
  • Takahashi-Tezuka M; Hibi M; Fujitani Y et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903. 
  • Laffargue M; Monnereau L; Tuech J et al. (1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochem. Biophys. Res. Commun. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487. 
  • Ohya K; Kajigaya S; Yamashita Y et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160. 
  • Kitanaka A, Mano H, Conley ME, Campana D (1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood 91 (3): 940–8. PMID 9446655. 
  • Yamashita Y; Watanabe S; Miyazato A et al. (1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood 91 (5): 1496–507. PMID 9473212. 
  • Yang WC, Ghiotto M, Barbarat B, Olive D (1999). "The role of Tec protein-tyrosine kinase in T cell signaling". J. Biol. Chem. 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994. 
  • Yang WC, Olive D (1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". Eur. J. Immunol. 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746. 
  • Ohya K; Kajigaya S; Kitanaka A et al. (1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.