DOK2

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Docking protein 2, 56kDa
Protein DOK2 PDB 2d9w.png
PDB rendering based on 2d9w.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DOK2 ; p56DOK; p56dok-2
External IDs OMIM604997 MGI1332623 HomoloGene2957 GeneCards: DOK2 Gene
RNA expression pattern
PBB GE DOK2 214054 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9046 13449
Ensembl ENSG00000147443 ENSMUSG00000022102
UniProt O60496 O70469
RefSeq (mRNA) NM_003974 NM_010071
RefSeq (protein) NP_003965 NP_034201
Location (UCSC) Chr 8:
21.77 – 21.77 Mb
Chr 14:
70.77 – 70.78 Mb
PubMed search [1] [2]

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[3]

Interactions[edit]

DOK2 has been shown to interact with INPP5D[4] and TEK tyrosine kinase.[5][6]

References[edit]

  1. ^ Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem 273 (9): 4827–30. doi:10.1074/jbc.273.9.4827. PMID 9478921. 
  2. ^ Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood 103 (6): 2088–95. doi:10.1182/blood-2003-07-2392. PMID 14645010. 
  3. ^ a b "Entrez Gene: DOK2 docking protein 2, 56kDa". 
  4. ^ Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173. 
  5. ^ Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820. 
  6. ^ Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432. 

Further reading[edit]